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Factors Regulating T Helper Cell Memory Differentiation

Factors Regulating T Helper Cell Memory Differentiation
调节 T 辅助细胞记忆分化的因素
批准号：
6684237
负责人：
ROBERT A SEDER
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6684237
关键词：
cell population study cytokine developmental immunology helper T lymphocyte immunologic memory immunoregulation laboratory mouse

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中文摘要
翻译
CD 4 + T细胞可以根据其细胞因子产生模式分为不同的亚群。分泌IFN-γ的CD 4 + T细胞称为Th 1细胞，而分泌IL-4、IL-5和IL-13的细胞称为Th 2细胞。虽然Th 1细胞在介导针对多种细胞内感染的保护中是必不可少的，但它们也介导与多种自身免疫性疾病相关的促炎反应。Th 2细胞具有反调节Th 1应答的作用，并且与过敏性和哮喘性疾病相关。这些研究检查了调节T辅助反应如何在体内持续的因素。
英文摘要
CD4+ T cells can be segregated into distinct subsets based on their pattern of cytokine production. CD4+ T cells that secrete IFN-g are termed Th1 cells while cells that secrete IL-4, IL-5 and IL-13 are termed Th2 cells. While Th1 cells are essential in mediating protection against a variety of intracellular infections they also are mediate pro-inflammatory responses associated with a variety of autoimmune diseases. Th2 cells have a role in counter-regulating Th1 responses and are associated with allergic and asthmatic disease. These studies examine the factors, which regulate how T helper responses are sustained in vivo.
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VACCINE DEVELOPMENT FOR TUBERCULOSIS
  • 批准号：
    7958684
  • 项目类别：
  • 资助金额：
    $5.57万
  • 财政年份：
    2009
  • 负责人：
    ROBERT A SEDER
  • 依托单位：
    TULANE UNIVERSITY OF LOUISIANA
DNA VACCINATION FOR PREVENTION OF VIRAL, PARASITIC AND MYCOBACTERIAL INFECTION
Development Of A Vaccine For Leishmania Major Infection
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