STUDY OF BIOMINERALIZATION MECHANISMS IN DENTIN

牙本质生物矿化机制的研究

• 批准号: 6634580
• 负责人: KOSTAS VERDELIS
• 金额: $ 12.71万
• 依托单位: HOSPITAL FOR SPECIAL SURGERY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2005-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6634580
• 关键词: animal tissue; bioimaging /biomedical imaging; dental visualization; dentinogenesis; electron microscopy; histology; infrared spectrometry; interferometry

This K08 application requests 4 years of support for the Study of Biomineralization Mechanisms in Dentin. Dr. Verdelis received a DDS and a specialty certification in endodontics and has finished required class work for the UNC PhD program. The first 3 years of this award will support the completion of his PhD training, and the last will provide the opportunity to apply for outside funding. The sponsor and primary mentor is Dr. Boskey, Director of Research at HSS, with Dr. Crenshaw at the Dental Research Center of UNC as co-mentor. In the proposed project, a model will be developed for the study of dentinogenesis of bovine incisors using FTIR imaging, electron microscopy, histomorphometry and microanalysis, with respect to the temporal distribution of dentin components during formation. Mantle and peritubular dentin will be compared to intertubular circumpulpal dentin. Knockout mice will also be analyzed to determine the importance of several matrix components. Since the candidate seeks an academic position in endodontics, combining research and clinical activities, this training in biomineralization mechanisms and hard tissue analysis will provide an understanding of the necessary research environment and provide guidance in preparing applications for funding support.

此K08申请要求4年的研究支持， 牙本质的生物矿化机制Verdelis医生收到了DDS和 在牙髓病学专业认证，并已完成所需的类工作， PhD计划。该奖项的前三年将支持 完成他的博士培训，最后将提供机会， 申请外部资金。赞助商和主要导师是博斯基博士， HSS的研究总监，与牙科研究中心的Crenshaw博士 我是你的导师。在拟议的项目中，将为 牛切牙牙本质形成过程的红外成像、电子显微镜观察 显微镜、组织形态测量和微观分析，相对于时间 牙本质成分在形成过程中的分布。外套管和管周 将牙本质与管间牙髓周围牙本质进行比较。敲除小鼠将 也可以分析，以确定几个矩阵组件的重要性。 由于候选人寻求牙髓病学的学术地位， 研究和临床活动，这种生物矿化机制的培训 和硬组织分析将提供必要的理解 研究环境，并提供指导，准备申请资助 支持.