Relapse Among Severely Mentally Ill Alcohol Abusers

严重精神疾病酗酒者复发

• 批准号: 6621161
• 负责人: Clara Margaret Bradizza
• 金额: $ 39.23万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2006-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6621161
• 关键词: adult human (21+); alcoholic beverage consumption; alcoholism /alcohol abuse; alcoholism /alcohol abuse chemotherapy; alcoholism /alcohol abuse therapy; antipsychotic agents; clinical research; comorbidity; coping; drug /alcohol abstinence; drug detection; epidemiology; gender difference; human subject; interview; longitudinal human study; mental disorders; mood disorders; questionnaires; racial /ethnic difference; relapse /recurrence; schizophrenia; substance abuse related behavior

The long-term goal of this proposed research is to develop effective methods for reducing posttreatment alcohol involvement among severely mentally ill (SMI) alcohol-abusing individuals. The specific aims of this research proposal are to test specific hypotheses summarized in a conceptual path model: 1. To examine the direct and indirect effects of psychiatric symptomatology on posttreatment alcohol involvement in schizophrenic individuals. Alcohol involvement outcome will be assessed by several variables including relapse to alcohol use, percent days abstinent, drinks per drinking day, and negative consequences due to alcohol use. It is anticipated that psychiatric symptoms will have both a direct influence on posttreatment alcohol involvement and an indirect effect through the dual-diagnosis treatment and coping skills factors. 2. To examine the direct and indirect effects of alcohol and other substance use problems on posttreatment alcohol involvement. It is predicted that alcohol and other substance use problems will have both a direct influence on alcohol involvement outcomes and an indirect effect through the dual- diagnosis treatment and coping skills factors. 3. To examine the direct and indirect effects of dual-diagnosis treatment on posttreatment alcohol involvement outcomes. It is predicted that dual-diagnosis treatment will have a direct influence on alcohol involvement outcomes and also an indirect effect through the coping skills factor. 4. To examine the direct influence of general and alcohol- specific coping skills on posttreatment alcohol involvement outcomes. It is predicted that poorer coping skills will lead to worse alcohol involvement outcomes. 5. To conduct exploratory analyses examining the moderating effects of gender, ethnic background, antipsychotic medications, and alcohol medications on the association between predictor variables derived from our mediational path model and alcohol involvement outcomes. A longitudinal design will be used to assess multiple measures of key constructs at treatment entry, and every two months thereafter for a period of six months. Key constructs include background characteristics, psychiatric symptomatology, alcohol and other substance use problems, treatment, coping skills, and alcohol involvement outcomes. Importantly, the results of this study will be used to gain an understanding of factors leading to posttreatment alcohol involvement among SMI individuals.

本研究的长期目标是开发有效的方法来减少重度精神疾病（SMI）酒精滥用者治疗后的酒精介入。本研究计划的具体目的是检验在概念路径模型中总结的具体假设：目的探讨精神分裂症患者治疗后酒精介入的精神症状学的直接和间接影响。涉及酒精的结果将通过几个变量来评估，包括酒精使用的复发、戒酒天数的百分比、每个饮酒日的饮酒量以及酒精使用的负面后果。预计精神症状会对治疗后酒精涉入产生直接影响，并通过双重诊断治疗和应对技能因素产生间接影响。2. 研究酒精和其他物质使用问题对治疗后酒精介入的直接和间接影响。预测酒精和其他物质使用问题将通过双重诊断治疗和应对技能因素对酒精介入结果产生直接影响和间接影响。3. 探讨双重诊断治疗对治疗后酒精涉入结局的直接和间接影响。预测双重诊断治疗对酒精涉入结果有直接影响，并通过应对技能因素产生间接影响。4. 目的：探讨一般和酒精特异性应对技能对治疗后酒精介入结果的直接影响。据预测，较差的应对技能将导致更糟糕的酒精卷入结果。5. 进行探索性分析，考察性别、种族背景、抗精神病药物和酒精药物对中介路径模型中预测变量与酒精介入结果之间关联的调节作用。纵向设计将用于在治疗开始时评估关键结构的多项措施，此后每两个月评估一次，为期六个月。关键结构包括背景特征、精神症状、酒精和其他物质使用问题、治疗、应对技能和酒精介入结果。重要的是，这项研究的结果将用于了解导致重度精神分裂症患者治疗后饮酒的因素。