Meeting on the Pathogenesis of Clostridia

梭菌发病机制会议

• 批准号: 6669954
• 负责人: ABRAHAM Lincoln SONENSHEIN
• 金额: $ 1万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-15 至 2004-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6669954
• 关键词: bacterial cytopathogenic effect; clostridial infection; meeting /conference /symposium; pathologic process

DESCRIPTION (provided by applicant): The Fourth International Conference on the Molecular Biology and Pathogenesis of the Clostridia will be held April 26-30, 2003 at the Marine Biological laboratories in Woods Hole, MA. This meeting will attract about 150 leading international clostridial researchers from universities, government laboratories, and commercial organizations. The conference will focus on new developments regarding the virulence and basic biology of the pathogenic clostridia, which remain major causes of natural enteric, histotoxic, and neurotoxic disease in humans and economically-important domestic animals. In addition, toxins produced by the pathogenic Clostridia have become major biodefense concerns, with botulinum toxins and C. perfringens epsilon toxin listed as Class A and B select agents, respectively. The conference's goal is two-fold: i) providing a common forum to discuss recent research findings in order to stimulate future progress, and it) training the next generation of clostridial researchers. To accomplish these purposes, the meeting consists of 10 sessions combining talks and posters. The first session will address the clostridial enterotoxins, which cause symptoms of several extremely important noscomial and foodborne diseases. The following session will concern the epidemiology, diagnosis and treatment of clostridial infections. Promising new practical medical and biotechnology applications of the pathogenic clostridia (and their toxins) will then be discussed in the third conference session. Session Four will then specifically focus on membrane-active clostridial toxins, which are so important for histotoxic infections such as gas gangrene. In the fifth session, the economically important clostridial veterinary diseases will be discussed. Exciting new insights provided by several clostridial genome projects will be presented in the 6th session, along with new information about clostridial mobile genetic elements, which are important for virulence. The seventh session will have considerable biodefense relevance since it includes the clostridial neurotoxins, including botulinum toxins. How clostridia regulate virulence gene expression will be the topic of the 8th session, to be followed in session 9 by a discussion of the linkage between clostridial physiology and virulence. The conference will conclude with an in-depth analysis of interactions between the pathogenic clostridia and their hosts in Session 10.

描述（由申请人提供）：第四届梭菌分子生物学和致病机理国际会议将于2003年4月26-30日在马萨诸塞州伍兹霍尔的海洋生物实验室举行。本次会议将吸引来自大学，政府实验室和商业组织的约150名国际领先的梭菌研究人员。会议将重点关注致病性梭菌的毒力和基础生物学方面的新进展，这仍然是人类和经济上重要的家畜的天然肠道，组织毒性和神经毒性疾病的主要原因。此外，致病梭菌产生的毒素已成为主要的生物防御问题，肉毒杆菌毒素和C。分别将产气荚膜梭菌毒素列为A类和B类选择剂。会议的目标是双重的：i）提供一个共同的论坛来讨论最近的研究结果，以促进未来的进展，和它）培训下一代梭菌研究人员。为了实现这些目的，会议由10个会议组成，包括讲座和海报。第一次会议将讨论梭菌肠毒素，它会引起几种极其重要的疾病和食源性疾病的症状。接下来的部分将涉及梭菌感染的流行病学、诊断和治疗。第三届会议将讨论致病梭菌（及其毒素）在医学和生物技术方面的新的实际应用。第四部分将特别关注膜活性梭菌毒素，这对组织毒性感染如气性坏疽非常重要。在第五次会议上，将讨论经济上重要的梭菌兽医疾病。由几个梭菌基因组项目提供的令人兴奋的新见解将在第六届会议上提出，沿着关于梭菌移动的遗传元件的新信息，这对毒力很重要。第七届会议将具有相当大的生物防御意义，因为它包括梭菌神经毒素，包括肉毒杆菌毒素。梭菌如何调节毒力基因的表达将是第8次会议的主题，随后在第9次会议上讨论梭菌生理学和毒力之间的联系。会议将在第10节深入分析致病性梭菌与宿主之间的相互作用。