Conference--Cartilage Biology and Pathology

描述（由申请人提供）： 碳水化合物在人类健康中起着至关重要的作用。软骨是骨骼形成和生长所必需的，也存在于骨的关节表面，经常受到损伤，导致严重的关节功能障碍。软骨疾病将在我们的老龄化人口中越来越占主导地位。对软骨生成机制和软骨疾病发病机制的进一步了解据说是生物医学研究的高度优先事项。 第一次戈登研究会议上的生物学和病理学的carpendum将讨论领域，其中令人兴奋的新进展已经取得。这将包括软骨发育生物学和软骨细胞分化的最新进展，对软骨细胞外基质成分及其相互作用的作用的新见解，我们对人类软骨疾病（包括骨关节炎和类风湿性关节炎以及越来越多的影响软骨的单基因疾病）的理解的进展，软骨降解机制研究的最新进展，和软骨的生物力学，以及软骨重塑和修复的最新进展，以及骨关节炎流行病学的新发现。在这些不同的领域取得了相当大的进展，拟议的演讲者的质量，会议的跨学科性质，来自学术界和制药公司的科学家的拟议组合，参与者中包括博士后，研究生和少数民族可能有助于本次会议的成功。会议将于2003年3月16日至21日在加州文图拉的假日酒店举行。 他们正在申请25,000美元的NIH支持，用于第一次戈登研究会议的生物学和病理学的Carpendia。

DESCRIPTION (provided by applicant): Cartilage plays an essential role in human health. Cartilages are needed for formation and growth of the skeleton and are also present at the joint surface of bones, frequently undergoing damage that results in severe joint dysfunction. Diseases of cartilage will be increasingly predominant in our aging population. An improved understanding of the mechanisms by which cartilages are generated and the pathogenesis of cartilage diseases are said to be a high priority in biomedical research. The first Gordon Research Conference on the Biology and Pathology of Cartilage will discuss areas in which exciting new progress has been achieved. This will include recent advances in the developmental biology of cartilage and differentiation of chondrocytes, new insights into the role of extracellular matrix components of cartilages and their interactions, advances in our understanding of human cartilage diseases including osteoarthritis and rheumatoid arthritis as well as a growing number of monogenetic diseases affecting cartilages, recent progress in studying the mechanisms of cartilage degradation, and the biomechanics of cartilages, as well as recent advances in cartilage remodeling and repair, and new findings in the epidemiology of osteoarthritis. The considerable progress that has been achieved in these different areas, the quality of the proposed speakers, the interdisciplinary nature of the conference, the proposed mix of Scientists from academia and pharmaceutical companies, the inclusion of postdocs, graduate students and minorities among the participants might contribute to the success of this conference. The conference will be held at the Holiday Inn Hotel, Ventura, California, March 16-21, 2003. They are requesting $25,000 in NIH support for the first Gordon Research Conference on the Biology and Pathology of Cartilage.