Nanostructured Membrane for Implantable Glucose Sensors

用于植入式血糖传感器的纳米结构膜

• 批准号: 6691777
• 负责人: DANNY T XIAO
• 金额: $ 28.79万
• 依托单位: INFRAMAT CORPORATION
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-26 至 2004-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6691777
• 关键词: artificial endocrine pancreas; biomaterial compatibility; biomaterial development /preparation; biomaterial evaluation; biomaterial interface interaction; biomedical equipment development; biosensor device; blood glucose; human tissue; implant; medical implant science; nanotechnology; surface coating

DESCRIPTION (provided by applicant): Long-term implantable biosensors have been commercially unavailable because a common problem associated with biosensors is protein deposition and fibrous encapsulation known as biofouling limiting device lifetime. Implantable biosensors can benefit greatly from improving membrane and coating layer structures using functional materials on biomembrane surfaces that reduce protein adsorption and the subsequent inflammatory response. Inframat Corporation proposes to demonstrate the feasibility of a novel nanostructured membrane for implantable glucose sensors. The proposed nanostructured membrane is expected to control tissue/glucose sensor interface interactions, thereby reducing protein adsorption while increasing biocompatibility for the sensor. This will extend glucose sensor lifetime. The proposed program consists of preparing a protein-resistant nanostructured membrane, evaluating its physical properties, and confirming improved performance in-vitro for glucose sensor applications. This program is based on our extensive experience in nanotechnology, particularly in nanostructured materials and coatings. Inframat is collaborating with Dr. George Wilson of the University of Kansas to evaluate the nanostructured membranes. The nanostructured membrane system can be used for a variety of implantable devices including biosensors, stents, hip and knee implants, and drug delivery systems. Anticipated socio-economic benefits of extending sensor lifetime include lower overall health costs to the nation, and improved quality of life.

描述(由申请人提供)： 由于与生物传感器相关的一个常见问题是蛋白质沉积和纤维封装，即所谓的生物污垢限制器件寿命，因此长期的植入式生物传感器在商业上是不可获得的。植入式生物传感器可以通过在生物膜表面使用功能材料来改善膜和涂层结构，从而减少蛋白质吸附和随后的炎症反应，从而大大受益。Infrmat公司建议证明一种用于植入式葡萄糖传感器的新型纳米结构膜的可行性。所提出的纳米结构膜有望控制组织/葡萄糖传感器界面的相互作用，从而减少蛋白质的吸附，同时提高传感器的生物相容性。这将延长葡萄糖传感器的使用寿命。拟议的计划包括制备一种耐蛋白质的纳米结构膜，评估其物理性能，并确认在体外葡萄糖传感器应用中性能的改善。该项目基于我们在纳米技术方面的丰富经验，特别是在纳米结构材料和涂料方面。Infrmat正在与堪萨斯大学的乔治·威尔逊博士合作评估纳米结构膜。纳米结构膜系统可用于各种植入性设备，包括生物传感器、支架、髋关节和膝盖植入物以及药物输送系统。延长传感器寿命的预期社会经济效益包括降低国家的总体医疗成本，以及提高生活质量。