Nanostructured Membrane for Implantable Glucose Sensors

用于植入式血糖传感器的纳米结构膜

• 批准号: 6803644
• 负责人: DANNY T XIAO
• 金额: $ 8.92万
• 依托单位: INFRAMAT CORPORATION
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-26 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6803644
• 关键词: artificial endocrine pancreas; biomaterial compatibility; biomaterial development /preparation; biomaterial evaluation; biomaterial interface interaction; biomedical equipment development; biosensor device; blood glucose; human tissue; implant; medical implant science; nanotechnology; surface coating

DESCRIPTION (provided by applicant): Long-term implantable biosensors have been commercially unavailable because a common problem associated with biosensors is protein deposition and fibrous encapsulation known as biofouling limiting device lifetime. Implantable biosensors can benefit greatly from improving membrane and coating layer structures using functional materials on biomembrane surfaces that reduce protein adsorption and the subsequent inflammatory response. Inframat Corporation proposes to demonstrate the feasibility of a novel nanostructured membrane for implantable glucose sensors. The proposed nanostructured membrane is expected to control tissue/glucose sensor interface interactions, thereby reducing protein adsorption while increasing biocompatibility for the sensor. This will extend glucose sensor lifetime. The proposed program consists of preparing a protein-resistant nanostructured membrane, evaluating its physical properties, and confirming improved performance in-vitro for glucose sensor applications. This program is based on our extensive experience in nanotechnology, particularly in nanostructured materials and coatings. Inframat is collaborating with Dr. George Wilson of the University of Kansas to evaluate the nanostructured membranes. The nanostructured membrane system can be used for a variety of implantable devices including biosensors, stents, hip and knee implants, and drug delivery systems. Anticipated socio-economic benefits of extending sensor lifetime include lower overall health costs to the nation, and improved quality of life.

描述（由申请人提供）： 长期可植入的生物传感器在商业上是不可用的，因为与生物传感器相关的常见问题是蛋白质沉积和被称为生物污染的纤维封装限制了装置寿命。植入式生物传感器可以大大受益于使用生物膜表面上的功能材料来改善膜和涂层结构，从而减少蛋白质吸附和随后的炎症反应。Rehmmat公司提出证明一种用于植入式葡萄糖传感器的新型纳米结构膜的可行性。所提出的纳米结构膜预计将控制组织/葡萄糖传感器界面相互作用，从而减少蛋白质吸附，同时增加传感器的生物相容性。这将延长葡萄糖探头的使用寿命。该计划包括制备抗蛋白质纳米结构膜，评估其物理特性，并确认葡萄糖传感器应用的体外性能改善。该计划是基于我们在纳米技术，特别是在纳米结构材料和涂层的丰富经验。Eschermat正在与堪萨斯大学的乔治威尔逊博士合作评估纳米结构膜。纳米结构膜系统可用于各种可植入装置，包括生物传感器、支架、髋关节和膝关节植入物以及药物递送系统。延长传感器寿命的预期社会经济效益包括降低国家的总体健康成本和提高生活质量。