Electrophoretic Nano-HA Coating for Improved Adhesion

电泳纳米 HA 涂层可提高附着力

• 批准号: 6947210
• 负责人: DANNY T XIAO
• 金额: $ 35.69万
• 依托单位: INFRAMAT CORPORATION
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-15 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6947210
• 关键词: adhesions; biological models; biomaterial development /preparation; biomaterial interface interaction; bone prosthesis; cell differentiation; cell proliferation; corrosions; dental implants; dogs; electrophoresis; hydroxyapatites; joint prosthesis; medical implant science; nanotechnology; osteoblasts; surface coating

DESCRIPTION (provided by applicant): This proposed phase II program is expected to produce prototype hydroxyapatite ("HA") coated bone implants with significantly extended lifetime, fabricated using a room temperature electrophoretic deposition process. Novel HA nanocoatings with significantly increased adhesion strength and corrosion resistance under simulated body fluid in-vitro have been demonstrated in the Phase I work. The proposed Phase II program emphasizes developing prototype implant devices to rapidly commercialize this Phase I nanotechnology. The benefits of exceptional coating to substrate bond strength enable expansion of the HA nanocoatings market to hips, knees, and dental applications. Achieving 100% crystallinity and density at the HA substrate interface with electrophoretic deposited HA nanocoatings assures no degradation during implant service. Functionally graded HA nanocoatings can be generated at the HA tissue interface, thus promoting optimal bioactivity. The Phase II specific aims include scale up of the experimental HA bath nanocoating composition to pilot-scale production of prototype medical implants; demonstration of the HA nanoparticles coating on prototype medical implants, such as hip, knee, and dental implants; and demonstration of superior performance of the coated prototype devices with extended lifetime in-vivo, using an animal model. Phase II participants include Spire Corporation and the University of Texas at San Antonio.

描述（由申请人提供）：该拟议的第二阶段计划预计将生产使用室温电泳沉积工艺制造的原型羟基磷灰石（“HA”）涂层骨植入物，其使用寿命显着延长。在第一阶段的工作中，新型HA纳米涂层在体外模拟体液下显着提高了附着强度和耐腐蚀性。拟议的第二阶段计划强调开发原型植入设备，以快速将第一阶段纳米技术商业化。卓越的涂层与基材粘合强度的优势使得 HA 纳米涂层市场扩展到臀部、膝盖和牙科应用。通过电泳沉积 HA 纳米涂层，在 HA 基底界面处实现 100% 结晶度和密度，确保在种植体使用过程中不会发生降解。功能分级的透明质酸纳米涂层可以在透明质酸组织界面生成，从而促进最佳的生物活性。第二阶段的具体目标包括将实验性 HA 浴纳米涂层组合物扩大到原型医疗植入物的中试规模生产；演示原型医疗植入物（例如髋关节、膝关节和牙科植入物）上的 HA 纳米颗粒涂层；并使用动物模型展示了涂层原型设备的卓越性能以及延长的体内使用寿命。第二阶段的参与者包括 Spire Corporation 和德克萨斯大学圣安东尼奥分校。