Neurotrophic LCP Plastic Substrate Nerve Electrode Array

神经营养性 LCP 塑料基板神经电极阵列

• 批准号: 6646388
• 负责人: BRIAN P FARRELL
• 金额: $ 10万
• 依托单位: FOSTER-MILLER, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-15 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6646388
• 关键词: action potentials; axon; bioengineering /biomedical engineering; electrodes; medical implant science; nerve; neurophysiology; neurotrophic factors

DESCRIPTION (provided by applicant): Foster-Miller proposes to develop the fabrication and assembly processes for mass produced, inexpensive, neurotrophic electrodes that can be used for exchanging information with central nerve tissue. Neurotrophic electrodes are designed to record from individual or multiple axon potentials recorded across a pair of wires inside its glass, conical tip. Current neurotrophic electrodes are manufactured by hand using small conical pieces of pulled glass pipettes and adding wire electrodes which are cemented in place. A batch process, based on photolithographic techniques would allow mass production of hundreds of these devices with many more electrodes per device than is currently possible. A dimensionally stable, biocompatible material for use in planar technology manufacturing has recently been identified based on Liquid Crystal Polymer (LCP) thermoplastics. LCP, when processed into thin, isotropic sheets, is a near ideal substrate material for nerve implants. This material can be processed in similar fashion to printed circuit boards and integrated circuits using photolithographic methods. Development of LCP based neurotrophic electrode arrays will enable expansion of existing research programs, creation of new areas of application, and enable many research groups to contribute to the development of neuroprostheses based on neurotrophic electrodes.

描述（由申请人提供）：Foster-Miller提议开发大规模生产的廉价神经营养电极的制造和组装工艺，该电极可用于与中枢神经组织交换信息。神经营养电极被设计成记录单个或多个轴突的电位，这些电位是通过其玻璃圆锥形尖端内的一对导线记录的。目前的神经营养电极是手工制造的，使用小锥形件的拉玻璃移液管和添加线电极，其被粘合在适当的位置。基于电火花技术的批量工艺将允许批量生产数百个这样的装置，每个装置具有比目前可能的多得多的电极。最近基于液晶聚合物（LCP）热塑性塑料确定了一种用于平面技术制造的尺寸稳定的生物相容性材料。LCP在加工成薄的各向同性片材时，是用于神经植入物的接近理想的基底材料。这种材料可以用类似于印刷电路板和集成电路的方式进行处理。基于LCP的神经营养电极阵列的开发将能够扩展现有的研究计划，创建新的应用领域，并使许多研究小组能够为基于神经营养电极的神经假体的开发做出贡献。