Advanced Collimators for Nuclear Medicine

用于核医学的先进准直器

• 批准号: 6645783
• 负责人: MICHAEL P APPLEBY
• 金额: $ 10万
• 依托单位: MIKRO SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2004-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6645783
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; image enhancement; nuclear medicine; radiation detector; radionuclide imaging /scanning

DESCRIPTION (provided by applicant): The long-term objective is to improve medical imaging quality, thereby improving detection, diagnosis, and therapy for a number of human health diseases. The specific aim of this research is to fabricate advanced high-resolution collimators for nuclear medicine imaging. An innovative fabrication technology will be used to produce advanced high-resolution collimators made from improved materials. The combination of a new fabrication method and new collimator materials offer important advantages in terms of design flexibility and performance over current collimator fabrication techniques. This is an enabling technology. Most importantly, it has the potential to allow very high-quality collimators to be produced at a relatively low cost. Phase I will demonstrate technical feasibility by fabricating prototype low energy high-resolution (LEHR) collimators employing a dense (-11 g/cc) composite material, and comparing their dimensional accuracy and imaging performance against state-of-the-art LEHR collimators commercially available. Phase II will refine the technological approach and extend the technology to other elements in an 'aligned' detector system including collimator, scintillator detector array, and optical interface elements. Potential commercial applications include nuclear medicine (small and large format cameras), computed tomography, mammography, as well as non-medical applications such as astrophysics, non-destructive testing, and security scanners.

描述（由申请人提供）： 长期目标是提高医学成像质量，从而改善许多人类健康疾病的检测、诊断和治疗。这项研究的具体目的是制造用于核医学成像的先进高分辨率准直器。 创新的制造技术将用于生产由改进材料制成的先进高分辨率准直器。新制造方法和新准直器材料的结合在设计灵活性和性能方面比当前准直器制造技术具有重要优势。这是一项使能技术。最重要的是，它有潜力以相对较低的成本生产非常高质量的准直器。 第一阶段将通过制造采用致密（-11 g/cc）复合材料的低能高分辨率（LEHR）准直器原型，并将其尺寸精度和成像性能与市售的最先进的 LEHR 准直器进行比较，来证明技术可行性。第二阶段将完善技术方法，并将该技术扩展到“对准”探测器系统中的其他元件，包括准直器、闪烁体探测器阵列和光学接口元件。 潜在的商业应用包括核医学（小型和大幅面相机）、计算机断层扫描、乳房X线照相术以及天体物理学、无损检测和安全扫描仪等非医疗应用。