Improved Scatter Reduction Grids for Mammography

改进的乳腺 X 线摄影散射减少网格

• 批准号: 6736023
• 负责人: MICHAEL P APPLEBY
• 金额: $ 36.87万
• 依托单位: MIKRO SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6736023
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; clinical research; diagnosis design /evaluation; diagnosis quality /standard; female; human subject; image enhancement; image processing; mammography; mathematics

DESCRIPTION (provided by applicant): This Phase II SBIR application proposes to develop improved scatter reduction grids for use in both digital and film screen mammography. Breast cancer is diagnosed in over 180,000 American women each year, leading to over 40,000 deaths annually. Screening mammography is currently the best diagnostic tool for breast disease. Scattered x-ray radiation reduces contrast in all radiographic images and is particularly problematic in mammography. High contrast imaging enables early detection of abnormalities (microcalcifications or unusual masses), which may suggest the presence of a cancer. MSI has developed an innovative process for producing advanced scatter reduction grids for mammography, using a cost effective fabrication technique, and an innovative grid material. In Phase I, MSI proved technical feasibility by designing and fabricating cellular anti-scatter grids made of a dense tungsten powder / polymer composite material. Laboratory testing and analysis demonstrated imaging performance in terms of primary transmission, scatter-to-primary ratio, contrast improvement factor and Bucky factor comparable to the best commercial anti-scatter grids currently available. The Phase II program will continue to develop this innovative fabrication technology with the following primary objectives: 1. The process will be scaled up to produce full-size (18 x 24 cm) mammography grids. 2. Grid movement schemes for film and digital based systems will be investigated and optimized. 3. Stationary anti-scatter grids for use with digital detectors will be designed, fabricated, and tested. 4. Phase II anti-scatter grids will be evaluated in laboratory and clinical testing.

描述（由申请人提供）：该 II 期 SBIR 申请建议开发改进的散射减少网格，用于数字和胶片屏幕乳房 X 线摄影。每年有超过 180,000 名美国女性被诊断出乳腺癌，每年导致超过 40,000 人死亡。筛查乳房X光检查是目前乳腺疾病最好的诊断工具。散射的 X 射线辐射会降低所有射线照相图像的对比度，这在乳房 X 射线照相术中尤其成问题。高对比度成像能够及早发现异常（微钙化或异常肿块），这可能表明癌症的存在。 MSI 开发了一种创新工艺，使用具有成本效益的制造技术和创新的网格材料来生产用于乳腺 X 光检查的先进散射减少网格。 在第一阶段，MSI 通过设计和制造由致密钨粉/聚合物复合材料制成的蜂窝防散射网格，证明了技术可行性。实验室测试和分析表明，其在主透射率、散射与主色比、对比度改进因子和巴基因子方面的成像性能可与目前最好的商用防散射栅格相媲美。第二阶段计划将继续开发这种创新制造技术，其主要目标如下： 1. 该工艺将扩大规模，以生产全尺寸（18 x 24 厘米）乳房X线摄影网格。 2. 将研究和优化电影和数字系统的网格移动方案。 3. 将设计、制造和测试与数字探测器一起使用的固定防散射栅格。 4. II 期防散射网格将在实验室和临床测试中进行评估。