Transient Thermal Modeling and Simulation Environment

瞬态热建模和仿真环境

• 批准号: 6691644
• 负责人: Nabil Elkouh
• 金额: $ 9.97万
• 依托单位: CREARE, LLC
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6691644
• 关键词: bioengineering /biomedical engineering; computer data analysis; computer program /software; computer simulation; computer system design /evaluation; mathematical model; mathematics; model design /development; thermography

DESCRIPTION (provided by applicant): Many biomedical applications involve the use of energy deposition into in homogeneous structures, such as laser surgery, cryosurgery, and RF ablation. In many cases, numerous advantages can be realized when the energy source is pulsed. No commercial software package exists to assist clinicians in determining the direction, duration, and magnitude of these energy interventions. In particular, existing predictive tools do not account for the effects associated with the laser interaction with thin tissues. While well-known approximations, such as the Diffusion Model, adequately account for interactions with thick tissue samples, they do not accurately model the effects associated with thin tissues where interactions with boundaries becomes important. Furthermore, when pulsed energy is deposited in tissue at ultra-high frequency, the subsequent conduction in the tissue no longer adheres to Fourier's conduction law, further complicating simulations. The specific aim of this project is to develop a general, commercial software modeling and simulation environment that will enable accurate assessment of heat transfer for biomedical applications involving energy deposition in tissues across the spectrums of thin to thick tissue layers and ultra-fast to continuous wave lasers, including those situations when non-Fourier heat conduction is important. Our thermal modeling and simulation environment will provide an easy-to-use tool for clinicians and biomedical researchers to plan accurately and understand a wide variety of pulsed and non-pulsed energy deposition-based clinical procedures. In Phase I, we will develop the general framework for a stand-alone software package that will be demonstrated with comparisons to experimental data, analytic solutions, and Monte Carlo simulations. In Phase II, we will develop a complete and robust package with an intuitive graphical user interface, refined models, and greatly expanded property data base developed in conjunction with our collaborators. We will also conduct appropriate experiments and work closely with clinicians to verify the underlying models and numerical schemes and gather additional required material properties.

描述（由申请人提供）：许多生物医学应用涉及在均匀结构中使用能量沉积，例如激光手术、冷冻手术和RF消融。在许多情况下，当能量源是脉冲的时，可以实现许多优点。没有商业软件包可以帮助临床医生确定这些能量干预的方向、持续时间和幅度。特别是，现有的预测工具不考虑与薄组织的激光相互作用的影响。虽然众所周知的近似，如扩散模型，充分考虑了与厚组织样本的相互作用，但它们不能准确地模拟与薄组织相关的影响，其中与边界的相互作用变得重要。此外，当脉冲能量以超高频沉积在组织中时，组织中的后续传导不再遵守傅立叶传导定律，从而使模拟进一步复杂化。该项目的具体目标是开发一个通用的商业软件建模和仿真环境，该环境将能够准确评估生物医学应用的热传递，这些应用涉及薄到厚组织层和超快到连续波激光的光谱中的组织中的能量沉积，包括非傅立叶热传导很重要的情况。我们的热建模和仿真环境将为临床医生和生物医学研究人员提供一个易于使用的工具，以准确规划和理解各种基于脉冲和非脉冲能量沉积的临床程序。在第一阶段，我们将开发一个独立的软件包，将与实验数据，分析解决方案和蒙特卡罗模拟进行比较，证明了一般框架。在第二阶段，我们将开发一个完整而强大的软件包，包括直观的图形用户界面，完善的模型，以及与我们的合作者一起开发的大大扩展的属性数据库。我们还将进行适当的实验，并与临床医生密切合作，以验证基础模型和数值方案，并收集额外的所需材料特性。