RETINAL BIREFRINGENCE ANALYSIS IN STRABISMUS & AMBLYOPIA

斜视的视网膜双折射分析

• 批准号: 6498354
• 负责人: David G HUNTER
• 金额: $ 32.79万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-02-01 至 2004-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6498354
• 关键词: amblyopia; binocular vision; birefringences; child (0-11); clinical research; cornea; diagnosis design /evaluation; diagnosis quality /standard; disease /disorder proneness /risk; early diagnosis; eye coordination disorder; eye disorder diagnosis; eye refraction disorder; fovea centralis retinae; human subject; mass screening; method development; optical polarization; polarimetry; retina

DESCRIPTION (Author Abstract): Amblyopia is the leading treatable cause of vision loss in childhood, with a prevalence of 2-5%. It is responsive to treatment early in life, but delayed treatment can result in life-long visual impairment. Unfortunately, health care practitioners are often unable to identify amblyopia risk factors, including strabismus, media opacities, and anisometropia, in patients under age 5, so that many cases of amblyopia go undetected and untreated. There is a need for a more effective method of detecting amblyopia risk factors. The fovea of the eye is surrounded by a distinctive pattern of birefrefringent fibers that change the polarization state of transmitted light. Our laboratory has developed a specialized form of retinal birefringence scanning (RBS), in which a small spot of polarized fight is scanned in a circle on the retina, and the returning fight measured for changes in polarization. We have demonstrated that RBS accurately (+/- 1 deg) detects foveal fixation in real time, in unrestrained subjects (including infants and children), making it possible to study patients with amblyopia and young children at risk for developing amblyopia. RBS has been characterized in only a small number of subjects, however, and little is known about individual variability. We have also developed binocular RBS (BRBS), which detects fixation of both eyes simultaneously and hence detects interocular alignment. The specific aims are to more fully characterize the RBS signal in normal and amblyopic subjects to enhance accuracy (hence sensitivity and specificity), and to screen normal and strabismic subjects using BRBS to identify amblyopia risk factors. BRBS may make it possible to screen infants and children automatically for the presence of amblyopia risk factors, including ocular misalignment, media opacity, and possibly refractive error, thereby facilitating early detection and treatment of this preventable form of blindness. The ability to screen for early, small deviations may help resolve conflicting findings on the efficacy of early amblyopia detection and treatment.

描述(作者摘要)：弱视是主要的可治疗原因 儿童时期视力丧失，患病率为2%-5%。它响应于 在生命早期接受治疗，但延迟治疗可能导致终身视力 减损。不幸的是，卫生保健从业者往往无法 确定弱视风险因素，包括斜视、媒体模糊和 屈光参差，在5岁以下的患者中，使许多弱视病例去 没有被发现也没有得到治疗。需要一种更有效的方法来 检测弱视危险因素。眼中央凹周围环绕着一个 改变偏振的双频条纹光纤的独特图案 透射光的状态。我们的实验室已经开发出一种特殊形式的 视网膜双折射扫描(RBS)，在其中有一小点偏振 在视网膜上扫描一个圆圈，然后测量返回的战斗 两极分化的变化。我们已经准确地证明了RBS(+/-1度) 实时检测无拘无束受试者的中心凹固定(包括 婴儿和儿童)，使研究弱视患者和 有患弱视风险的幼儿。苏格兰皇家银行的特点是 然而，只有一小部分受试者，而且对个人知之甚少 可变性。我们还开发了双目RBS(BRBS)，它可以检测到 双眼同时注视，因此可以检测眼球间的排列。 具体目标是更全面地描述RBS信号在正常和 弱视受试者，以提高准确性(因此敏感性和特异性)，以及 使用BRBS筛查正常和斜视受试者以确定弱视风险 各种因素。BRBS可能使对婴儿和儿童进行自动筛查成为可能 对于弱视危险因素的存在，包括眼球不对准， 媒体不透明，以及可能的屈光误差，从而有助于及早 这种可预防形式的失明的检测和治疗。有能力 筛选早期的、小的偏差可能有助于解决关于 弱视早期发现和治疗的效果。