RETINAL BIREFRINGENCE ANALYSIS IN STRABISMUS & AMBLYOPIA

斜视的视网膜双折射分析

• 批准号: 6608077
• 负责人: David G HUNTER
• 金额: $ 33.69万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-02-01 至 2006-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6608077
• 关键词: amblyopia; binocular vision; birefringences; child (0-11); clinical research; cornea; diagnosis design /evaluation; diagnosis quality /standard; disease /disorder proneness /risk; early diagnosis; eye coordination disorder; eye disorder diagnosis; eye refraction disorder; fovea centralis retinae; human subject; mass screening; method development; optical polarization; polarimetry; retina

DESCRIPTION (Author Abstract): Amblyopia is the leading treatable cause of vision loss in childhood, with a prevalence of 2-5%. It is responsive to treatment early in life, but delayed treatment can result in life-long visual impairment. Unfortunately, health care practitioners are often unable to identify amblyopia risk factors, including strabismus, media opacities, and anisometropia, in patients under age 5, so that many cases of amblyopia go undetected and untreated. There is a need for a more effective method of detecting amblyopia risk factors. The fovea of the eye is surrounded by a distinctive pattern of birefrefringent fibers that change the polarization state of transmitted light. Our laboratory has developed a specialized form of retinal birefringence scanning (RBS), in which a small spot of polarized fight is scanned in a circle on the retina, and the returning fight measured for changes in polarization. We have demonstrated that RBS accurately (+/- 1 deg) detects foveal fixation in real time, in unrestrained subjects (including infants and children), making it possible to study patients with amblyopia and young children at risk for developing amblyopia. RBS has been characterized in only a small number of subjects, however, and little is known about individual variability. We have also developed binocular RBS (BRBS), which detects fixation of both eyes simultaneously and hence detects interocular alignment. The specific aims are to more fully characterize the RBS signal in normal and amblyopic subjects to enhance accuracy (hence sensitivity and specificity), and to screen normal and strabismic subjects using BRBS to identify amblyopia risk factors. BRBS may make it possible to screen infants and children automatically for the presence of amblyopia risk factors, including ocular misalignment, media opacity, and possibly refractive error, thereby facilitating early detection and treatment of this preventable form of blindness. The ability to screen for early, small deviations may help resolve conflicting findings on the efficacy of early amblyopia detection and treatment.

描述（作者摘要）：弱视是导致弱视的主要可治疗原因 儿童期视力丧失，患病率为 2-5%。它响应于 在生命早期接受治疗，但延迟治疗可能会导致终生视力下降 损害。不幸的是，医疗保健从业者往往无法 识别弱视危险因素，包括斜视、媒介混浊和 屈光参差，发生在5岁以下的患者中，因此许多弱视病例 未被发现和未被治疗。需要一种更有效的方法 检测弱视危险因素。眼睛的中央凹被一个 改变偏振的双折射光纤的独特图案 透射光的状态。我们的实验室开发了一种专门的形式 视网膜双折射扫描（RBS），其中一个小点的偏振战斗 在视网膜上进行一圈扫描，然后测量返回的战斗时间 极化的变化。我们已经证明 RBS 准确（+/- 1 度） 实时检测不受约束的受试者（包括 婴儿和儿童），使得研究弱视患者和 幼儿有患弱视的风险。 RBS 的特点是 然而，只有少数主题，而且对个人知之甚少。 可变性。我们还开发了双目 RBS (BRBS)，可检测 同时注视双眼，从而检测眼间对准。 具体目标是更全面地表征正常和正常状态下的 RBS 信号。 弱视受试者提高准确性（因此敏感性和特异性），以及 使用 BRBS 筛查正常和斜视受试者以确定弱视风险 因素。 BRBS 可能使婴儿和儿童自动筛查成为可能 存在弱视危险因素，包括眼部错位， 介质混浊，以及可能的屈光不正，从而促进早期 检测和治疗这种可预防的失明形式。有能力 筛查早期的小偏差可能有助于解决相互矛盾的发现 早期弱视检测和治疗的功效。

项目成果

Automated detection of ocular focus.

自动检测眼部焦点。

• DOI: 10.1117/1.1781669
• 发表时间: 2004
• 期刊: Journal of biomedical optics
• 影响因子: 3.5
• 作者: Hunter,DavidG;Nusz,KevinJ;Gandhi,NaineshK;Quraishi,ImranH;Gramatikov,BorisI;Guyton,DavidL
• 通讯作者: Guyton,DavidL

The Pediatric Vision Screener III: detection of strabismus in children.

儿科视力筛查仪 III：检测儿童斜视。

• DOI: 10.1001/archopht.124.4.509
• 发表时间: 2006
• 期刊: Archives of ophthalmology (Chicago, Ill. : 1960)
• 作者: Nassif,DeborahS;Piskun,NadyaV;Hunter,DavidG
• 通讯作者: Hunter,DavidG