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Array Detectors for Accelerated Small Animal MRI

用于加速小动物 MRI 的阵列探测器

基本信息

批准号：
6830546
负责人：
James A Bankson
金额：
$ 22.65万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-08-01 至 2006-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6830546
关键词：
bioengineering /biomedical engineering bioimaging /biomedical imaging biomedical equipment development biotechnology computer program /software high throughput technology image enhancement laboratory mouse magnetic resonance imaging neoplasm /cancer neoplasm /cancer diagnosis whole body imaging /scanning

项目摘要

DESCRIPTION (provided by applicant) The University of Texas MD Anderson Cancer Center Small Animal Cancer Research Imaging Facility is a core institutional resource that provides imaging instrumentation and operational support for investigations that require imaging based measurement of small animal models of cancer. A four channel, 4.7T Bruker Biospec experimental NMR/MRI scanner is a major component of this program. This instrument is highly utilized with significant demand for the imaging of larger numbers of animals. The objective of this proposal is to implement and evaluate parallel imaging strategies that accelerate datacquisition rates, thereby reducing scan times, increasing the number of animals that can be scanned per unit time, allowing greater access to the instrument, and reducing the overall cost per data point incurred to investigators through facility charge back policies. Parallel acquisition strategies will be implemented that allow the simultaneous acquisition of imaging data from several animals at once. A very simple implementation of an array of volume coils, manufactured entirely from components that are commercially available will be assembled and evaluated in terms of application limitations and overall increase in animal throughput. Such a straightforward configuration would allow UTMDACC and virtually any site with multichannel capabilities to immediately achieve high-resolution imaging of multiple volumes with minimal investment in development time. This collaborative effort has been established between UTMDACC and Bruker Biospin MRI out of common interest in enhancing throughput using these instruments.

描述（由申请人提供）德克萨斯大学医学博士安德森癌症中心小动物癌症研究成像设施是一个核心的机构资源，为需要基于成像的癌症小动物模型测量的研究提供成像仪器和操作支持。四通道4.7T Bruker Biospec实验NMR/MRI扫描仪是该计划的主要组成部分。该仪器的使用率很高，对大量动物的成像需求很大。本提案的目的是实施和评估并行成像策略，加快数据采集速率，从而减少扫描时间，增加单位时间内可扫描的动物数量，允许更多地使用仪器，并通过设施收费政策降低研究者每个数据点的总成本。将实施并行采集策略，允许同时采集几只动物的成像数据。一个非常简单的实现的体积线圈阵列，完全由组件制造的商业上可获得的将组装和评估方面的应用限制和整体增加动物吞吐量。这种简单的配置将允许UTMDACC和几乎任何具有多通道功能的站点立即实现多个卷的高分辨率成像，同时在开发时间上投入最少。UTMDACC和Bruker Biospin MRI之间建立了这种合作努力，这是出于对使用这些仪器提高通量的共同兴趣。