Core 1: Pathology Core

核心 1：病理学核心

• 批准号: 10005290
• 负责人: JINSONG LIU
• 金额: $ 21.97万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-22 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10005290
• 关键词: Archives; Ascites; Award; Back; Basic Science; Benign; Biopsy Specimen; Blood; Blood specimen; Cancer Center; Charge; Clinical; Clinical Data; Clinical Research; Code; Collection; Confidentiality of Patient Information; Consult; Databases; Development; Diagnosis; Disease Marker; Doctor of Medicine; Endometrium; Evaluation; Experimental Designs; Feasibility Studies; Female Genital Neoplasms; Formalin; Freezing; Frozen Sections; Funding; Generations; Genes; Goals; Human; Immunohistochemistry; In Situ Hybridization; Individual; Internet; Intranet; Laboratories; Laboratory Research; Link; Liquid substance; Malignant neoplasm of ovary; Mammalian Oviducts; Microdissection; Microscopic; Mucous Membrane; Mus; Normal tissue morphology; Operative Surgical Procedures; Ovarian; Ovarian Diseases; Ovary; Paraffin Embedding; Pathologic; Pathologist; Pathology; Patients; Pelvis; Population Research; Population Study; Process; Prognostic Marker; Recurrence; Research; Research Personnel; Research Project Grants; Research Proposals; Research Support; Resources; Risk; Sampling; Security; Services; Slide; Solid Neoplasm; Source; Specimen; Technology; Testing; Tissue Banks; Tissue Embedding; Tissue Microarray; Tissue Sample; Tissues; Translational Research; Tumor Bank; Tumor Tissue; Urine; Xenograft procedure; base; career; data access; diagnostic biomarker; early detection biomarkers; experience; experimental study; novel; quality assurance; ranpirnase; repository; tumor; virtual

Core 1: Pathology SUMMARY/ ABSTRACT The individual research projects comprising this Ovarian Cancer SPORE application require the procurement, processing, and analysis of histopathological material from patients with ovarian cancer and benign ovarian diseases. The research projects have needs for frozen and formalin-fixed, paraffin-embedded samples of tumor and normal tissue. The proposed Pathology Core augments the already established MD Anderson Cancer Center Gynecological Tumor Bank and the P30-sponsored MD Anderson Cancer Center Centralized Tissue Repository with supporting database and intranet access. The Core provides for tissue acquisition by experienced gynecological pathologists to assure high-quality tissues for the investigators participating in this SPORE as well as investigators of other SPOREs. The goal of the Pathology Core is to provide frozen tissue, paraffin-embedded tissue, and histopathological expertise related to the specific needs of the research projects comprising this SPORE proposal. To achieve this goal, the Pathology Core proposes the following Specific Aims: Aim 1 is to maintain a frozen and paraffin-embedded tissue repository of ovarian cancer, benign ovarian processes, and normal ovary. The primary tissue source will be operative and biopsy specimens submitted to the Department of Pathology at MD Anderson Cancer Center. Aim 2 is to provide pathological review for all clinical specimens utilized in the SPORE projects and to provide histopathological technical services as necessary. Such technical services include immunohistochemistry, in situ hybridization, creation of specific tissue microarray slides, pathological evaluation of mouse tumors, and microdissection of tissue sections. Aim 3 is to establish a blood/urine/ascites fluid repository from patients undergoing surgery for ovarian cancer and benign ovarian processes. These fluids will provide the resources for the testing of putative prognostic and diagnostic markers derived from experiments in the SPORE projects. Aim 4 is to create and maintain a relational SPORE Database for all samples collected by the Pathology Core. This SPORE Database will provide for a virtual tissue repository that can be shared electronically with all SPORE investigators.

核心1：病理摘要/摘要 包括这项卵巢癌孢子应用的个别研究项目需要采购， 卵巢癌和良性卵巢患者的组织病理学材料的加工和分析 疾病。研究项目需要冷冻和福尔马林固定，石蜡包裹的样品的样本 肿瘤和正常组织。拟议的病理核心增强了已经建立的MD Anderson 癌症中心妇科肿瘤库和P30赞助的MD Anderson癌症中心集中 具有支持数据库和Intranet访问的组织存储库。核心提供了通过 经验丰富 孢子以及其他孢子的研究者。 病理核心的目的是提供冷冻的组织，石蜡包裹的组织和组织病理学 与包括该孢子提案的研究项目的特定需求有关的专业知识。实现 该目标，病理核心提出以下特定目的：目标1是保持冷冻和 卵巢癌，良性卵巢过程和正常卵巢的石蜡包裹的组织存储库。这 主要组织源将是手术和活检标本，提交给医学博士病理学系 安德森癌症中心。 AIM 2是为所有在 孢子项目并根据需要提供组织病理学技术服务。这样的技术服务 包括免疫组织化学，原位杂交，特定组织微阵列载玻片，病理学 小鼠肿瘤的评估和组织切片的显微解剖。目标3是建立血液/尿液/腹水 接受卵巢癌和良性卵巢过程手术的患者的流体存储库。这些 流体将为测试推定的预后和诊断标记的资源提供资源 孢子项目中的实验。 AIM 4是为所有人创建和维护一个关系孢子数据库 病理核心收集的样品。该孢子数据库将提供一个虚拟组织存储库 可以与所有孢子调查员以电子方式共享。