Core 1: Pathology Core

核心1：病理学总结/摘要 包括卵巢癌孢子应用程序的个人研究项目需要采购， 卵巢癌和良性卵巢癌患者的组织病理学材料的处理和分析 疾病研究项目需要冷冻和福尔马林固定，石蜡包埋的样本， 肿瘤和正常组织。拟议的病理学核心增强了已经建立的MD安德森 癌症中心妇科肿瘤库和P30赞助的MD安德森癌症中心集中 组织储存库，支持数据库和内联网访问。核心通过以下方式提供组织采集 经验丰富的妇科病理学家，以确保高质量的组织，为研究者参与这一 SPORE以及其他SPORE的调查人员。 病理学核心的目标是提供冷冻组织、石蜡包埋组织和组织病理学检查。 与包括本SPORE提案的研究项目的特定需求相关的专业知识。实现 为了实现这一目标，病理学核心提出了以下具体目标：目标1是保持冷冻， 卵巢癌、良性卵巢过程和正常卵巢的石蜡包埋组织库。的 主要组织来源将是提交给MD病理科的手术和活检标本 安德森癌症中心。目的2是为所有临床标本提供病理学检查， 在必要时提供组织病理学技术服务。此类技术服务 包括免疫组织化学、原位杂交、产生特异性组织微阵列载玻片、病理 小鼠肿瘤的评价和组织切片的显微切割。目的3是建立血液/尿液/腹水 来自接受卵巢癌和良性卵巢过程手术的患者的液体储存库。这些 液体将提供资源，用于检测推定的预后和诊断标志物， 在SPORE项目中进行实验。目标4是为所有人创建和维护一个关系型SPORE数据库 病理学中心收集的样本该SPORE数据库将提供一个虚拟组织库， 可以通过电子方式与所有SPORE调查人员共享。

Core 1: Pathology SUMMARY/ ABSTRACT The individual research projects comprising this Ovarian Cancer SPORE application require the procurement, processing, and analysis of histopathological material from patients with ovarian cancer and benign ovarian diseases. The research projects have needs for frozen and formalin-fixed, paraffin-embedded samples of tumor and normal tissue. The proposed Pathology Core augments the already established MD Anderson Cancer Center Gynecological Tumor Bank and the P30-sponsored MD Anderson Cancer Center Centralized Tissue Repository with supporting database and intranet access. The Core provides for tissue acquisition by experienced gynecological pathologists to assure high-quality tissues for the investigators participating in this SPORE as well as investigators of other SPOREs. The goal of the Pathology Core is to provide frozen tissue, paraffin-embedded tissue, and histopathological expertise related to the specific needs of the research projects comprising this SPORE proposal. To achieve this goal, the Pathology Core proposes the following Specific Aims: Aim 1 is to maintain a frozen and paraffin-embedded tissue repository of ovarian cancer, benign ovarian processes, and normal ovary. The primary tissue source will be operative and biopsy specimens submitted to the Department of Pathology at MD Anderson Cancer Center. Aim 2 is to provide pathological review for all clinical specimens utilized in the SPORE projects and to provide histopathological technical services as necessary. Such technical services include immunohistochemistry, in situ hybridization, creation of specific tissue microarray slides, pathological evaluation of mouse tumors, and microdissection of tissue sections. Aim 3 is to establish a blood/urine/ascites fluid repository from patients undergoing surgery for ovarian cancer and benign ovarian processes. These fluids will provide the resources for the testing of putative prognostic and diagnostic markers derived from experiments in the SPORE projects. Aim 4 is to create and maintain a relational SPORE Database for all samples collected by the Pathology Core. This SPORE Database will provide for a virtual tissue repository that can be shared electronically with all SPORE investigators.