Translational Research in Alzheimer's Disease and related Dementias (TRADD)

阿尔茨海默病和相关痴呆症的转化研究 (TRADD)

• 批准号: 10709167
• 负责人: ROBERTA EILEEN BRINTON
• 金额: $ 29.45万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10709167
• 关键词: Alzheimer' s disease related dementia; Translational Research

Project Summary/Abstract The University of Arizona (UArizona) Training Program to Advance Translational Research on Alzheimer's Disease and AD Related Dementias (AZ-TRADD) is designed to address knowledge and experience gaps in AD therapeutic discovery and preclinical translational development. To meet this challenge, the UArizona Translational Research in AD and related Dementias (AZ-TRADD) training program is designed as a problem based translational learning experience for predoctoral Ph.D and M.D./Ph.D fellows. In alignment with the 2021 NIH Alzheimer’s Research Summit: Path to Precision Medicine for Treatment and Prevention and the 2011 National Alzheimer’s Project Act (NAPA), the goal of the AZ-TRADD training program is to fill critical gaps that exist for AD translational research in academic graduate programs. To achieve this goal, the AZ-TRADD program will: 1) recruit trainees across multiple scientific disciplines; 2) employ problem-based learning approaches to solve challenges in AD therapeutic development with emerging tools and techniques; and 3) equip AZ-TRADD trainees with career development and leadership skills necessary to conduct team science and manage multidisciplinary teams. Through this approach, we ensure that AZ-TRADD trainees develop deep translational research expertise necessary for AD therapeutic development, while: 1) cultivating the ability to creatively and collaboratively solve problems working with experts across the translational landscape as part of large-scale team science; 2) gaining an applied understanding of how data science, particularly using data generated by AMP-AD, M2OVE-AD and ADNI, can accelerate translational research and provide avenues to novel therapeutic insights; 3) connecting geno- and phenotypic variations and multifaceted etiology of AD to therapeutic targets; and 4) gaining essential professional and business skills to navigate a diverse funding landscape and translate discoveries into the clinical setting. AZ-TRADD fellows will receive career mentoring and leadership development skills to manage multi-disciplinary teams in the 21st century that is Patient Inspired and Data Driven. The AZ- TRADD training program will develop a diverse, cross-disciplinary, and translationally oriented workforce to meet the critical challenge of creating a workforce capable of advancing therapeutics to prevent, delay, and treat AD and AD related dementias.

项目总结/摘要 亚利桑那大学（UArizona）培训计划，以推进阿尔茨海默氏症的转化研究 疾病和AD相关痴呆（AZ-TRADD）旨在解决AD的知识和经验差距 治疗发现和临床前转化开发。为了应对这一挑战，亚利桑那大学 AD和相关痴呆的转化研究（AZ-TRADD）培训计划是作为一个问题而设计的 博士前博士和医学博士的翻译学习经验/博士研究员。为了配合2021年 NIH阿尔茨海默氏症研究峰会：治疗和预防的精准医学之路以及2011年 国家阿尔茨海默病项目法案（NAPA），AZ-TRADD培训计划的目标是填补关键空白， 存在于学术研究生课程中的AD转化研究。为了实现这一目标，AZ-TRADD计划 将：1）招募跨多个科学学科的受训人员; 2）采用基于问题的学习方法， 用新兴工具和技术解决AD治疗开发中的挑战; 3）装备AZ-TRADD 具有职业发展和领导技能的学员，以进行团队科学和管理 多学科团队。通过这种方法，我们确保AZ-TRADD学员能够培养深度翻译能力， AD治疗开发所需的研究专业知识，同时：1）培养创造性和 作为大规模翻译工作的一部分， 团队科学; 2）获得对数据科学如何应用的理解，特别是使用 AMP-AD、M2 OVE-AD和ADNI可以加速转化研究，并为开发新的治疗药物提供途径。 3）将基因型和表型变异以及AD的多方面病因学与治疗靶点联系起来; 以及4）获得必要的专业和商业技能，以驾驭多样化的融资环境，并将其转化为 将新发现应用于临床。AZ-TRADD研究员将获得职业指导和领导力发展 在21世纪管理多学科团队的技能，即患者启发和数据驱动。AZ- TRADD培训计划将培养一支多元化、跨学科和专业化的员工队伍，以满足 创建一支能够推进预防、延迟和治疗AD疗法的工作队伍的关键挑战 以及AD相关痴呆症。