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Microelectrode Recordings from the Vagus Nerve in Awake Humans

清醒人类迷走神经的微电极记录

基本信息

批准号：
10709640
负责人：
Vaughan Gary Macefield
金额：
$ 20.68万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-23 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10709640
关键词：
Abdomen Affect Anatomy Anxiety Disorders Autonomic nervous system Axon Blood Pressure Cardiac Chest Chronic Clinical Clinical Research Common Core Cranial Nerves Data Development Devices Distal Electrodes Epilepsy Fascicle Fiber Frequencies Future Gastrointestinal Diseases Gastrointestinal tract structure Heart Human Implant Implanted Electrodes Intractable Epilepsy Investigation Italy Lung Measures Mental Depression Metals Microelectrodes Morphology Motor Muscle Myelinated nerve fiber Neck Nerve Nerve Fibers Operative Surgical Procedures Organ Outcome Paper Parasympathetic Nervous System Participant Patients Phase Physiologic pulse Physiology Protocols documentation Publishing Randomized Rattus Report (document)Reporting Research Running Sensory Sensory Physiology Series Site Skin Source Specific qualifier value Stimulus Structure Sympathetic Nervous System Titrations Training Unmyelinated Nerve Fibers Vagus nerve structure Visceral Width Work awake body system carbon fiber flexibility heart rate variability motor control nerve supply neural neurophysiology novel operation organ growth recruit respiratory tool ultrasound

项目摘要

ANCILLARY PROJECT 1 Abstract: Microelectrode Recordings from the Vagus Nerve in Awake Humans The vagus nerve, the longest cranial nerve, supplies structures in the neck, thorax, and abdomen with sensory and motor innervation, including parasympathetic innervation to the heart, lungs, airways, and gut. Unlike the sympathetic nervous system, in which it has been possible to make direct microelectrode recordings in humans for >50 years, it has not been possible to record parasympathetic outflow directly – until now. We developed an ultrasound-guided approach that allows us to record directly from the vagus nerve via a microelectrode inserted percutaneously into the neck of awake humans. In this Ancillary Project, we plan to build upon our preliminary data from this approach by undertaking a detailed neurophysiological investigation of the human vagus nerve and identifying the nerve fibers activated during vagal nerve stimulation, both sensory and motor (including parasympathetic) axons. This may provide a specified range of stimulus intensities required to excite myelinated and unmyelinated nerve fibers in the Clinical Study Protocol as described in the Clinical Core. It will also provide unprecedented detail into the physiology of the human vagus nerve and inform future development of novel intrafascicular neural interfaces.

摘要：清醒人类迷走神经的微电极记录