Microelectrode Recordings from the Vagus Nerve in Awake Humans

清醒人类迷走神经的微电极记录

• 批准号: 10610560
• 负责人: Vaughan Gary Macefield
• 金额: $ 21.81万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-23 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10610560
• 关键词: Abdomen; Affect; Anatomy; Anxiety Disorders; Autonomic nervous system; Axon; Blood Pressure; Cardiac; Chest; Chronic; Clinical; Clinical Research; Common Core; Cranial Nerves; Data; Development; Devices; Distal; Electrodes; Epilepsy; Fascicle; Fiber; Frequencies; Future; Gastrointestinal Diseases; Gastrointestinal tract structure; Heart; Human; Implant; Implanted Electrodes; Institutes; Intractable Epilepsy; Investigation; Italy; Lung; Measures; Mental Depression; Metals; Microelectrodes; Morphology; Motor; Muscle; Myelinated nerve fiber; Neck; Nerve; Nerve Fibers; Operative Surgical Procedures; Organ; Outcome; Paper; Parasympathetic Nervous System; Participant; Patients; Phase; Physiologic pulse; Physiology; Protocols documentation; Publishing; Randomized; Rattus; Report (document); Reporting; Research; Running; Sensory; Sensory Physiology; Series; Site; Skin; Source; Specific qualifier value; Stimulus; Structure; Sympathetic Nervous System; Titrations; Training; Unmyelinated Nerve Fibers; Vagus nerve structure; Visceral; Width; Work; awake; body system; carbon fiber; flexibility; heart rate variability; motor control; nerve supply; neurophysiology; novel; operation; organ growth; recruit; relating to nervous system; respiratory; tool; ultrasound

ANCILLARY PROJECT 1 Abstract: Microelectrode Recordings from the Vagus Nerve in Awake Humans The vagus nerve, the longest cranial nerve, supplies structures in the neck, thorax, and abdomen with sensory and motor innervation, including parasympathetic innervation to the heart, lungs, airways, and gut. Unlike the sympathetic nervous system, in which it has been possible to make direct microelectrode recordings in humans for >50 years, it has not been possible to record parasympathetic outflow directly – until now. We developed an ultrasound-guided approach that allows us to record directly from the vagus nerve via a microelectrode inserted percutaneously into the neck of awake humans. In this Ancillary Project, we plan to build upon our preliminary data from this approach by undertaking a detailed neurophysiological investigation of the human vagus nerve and identifying the nerve fibers activated during vagal nerve stimulation, both sensory and motor (including parasympathetic) axons. This may provide a specified range of stimulus intensities required to excite myelinated and unmyelinated nerve fibers in the Clinical Study Protocol as described in the Clinical Core. It will also provide unprecedented detail into the physiology of the human vagus nerve and inform future development of novel intrafascicular neural interfaces.

辅助项目 1 摘要：清醒人类迷走神经的微电极记录 迷走神经是最长的脑神经，为颈部、胸部和腹部的结构提供感觉和运动神经支配，包括对心脏、肺、气道和肠道的副交感神经支配。与交感神经系统不同，交感神经系统在人体中进行直接微电极记录已有超过 50 年的历史，而迄今为止，还无法直接记录副交感神经的流出。我们开发了一种超声引导方法，使我们能够通过经皮插入清醒人类颈部的微电极直接从迷走神经进行记录。在这个辅助项目中，我们计划基于这种方法的初步数据，对人类迷走神经进行详细的神经生理学研究，并识别迷走神经刺激期间激活的神经纤维，包括感觉和运动（包括副交感神经）轴突。这可以提供在临床研究方案中激发有髓和无髓神经纤维所需的指定刺激强度范围，如临床核心中所述。它还将为人类迷走神经的生理学提供前所未有的细节，并为新型束内神经接口的未来发展提供信息。