Microelectrode Recordings from the Vagus Nerve in Awake Humans

清醒人类迷走神经的微电极记录

基本信息

批准号：
10610560
负责人：
Vaughan Gary Macefield
金额：
$ 21.81万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-23 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10610560
关键词：
Abdomen Affect Anatomy Anxiety Disorders Autonomic nervous system Axon Blood Pressure Cardiac Chest Chronic Clinical Clinical Research Common Core Cranial Nerves Data Development Devices Distal Electrodes Epilepsy Fascicle Fiber Frequencies Future Gastrointestinal Diseases Gastrointestinal tract structure Heart Human Implant Implanted Electrodes Institutes Intractable Epilepsy Investigation Italy Lung Measures Mental Depression Metals Microelectrodes Morphology Motor Muscle Myelinated nerve fiber Neck Nerve Nerve Fibers Operative Surgical Procedures Organ Outcome Paper Parasympathetic Nervous System Participant Patients Phase Physiologic pulse Physiology Protocols documentation Publishing Randomized Rattus Report (document)Reporting Research Running Sensory Sensory Physiology Series Site Skin Source Specific qualifier value Stimulus Structure Sympathetic Nervous System Titrations Training Unmyelinated Nerve Fibers Vagus nerve structure Visceral Width Work awake body system carbon fiber flexibility heart rate variability motor control nerve supply neurophysiology novel operation organ growth recruit relating to nervous system respiratory tool ultrasound

项目摘要

ANCILLARY PROJECT 1 Abstract: Microelectrode Recordings from the Vagus Nerve in Awake Humans The vagus nerve, the longest cranial nerve, supplies structures in the neck, thorax, and abdomen with sensory and motor innervation, including parasympathetic innervation to the heart, lungs, airways, and gut. Unlike the sympathetic nervous system, in which it has been possible to make direct microelectrode recordings in humans for >50 years, it has not been possible to record parasympathetic outflow directly – until now. We developed an ultrasound-guided approach that allows us to record directly from the vagus nerve via a microelectrode inserted percutaneously into the neck of awake humans. In this Ancillary Project, we plan to build upon our preliminary data from this approach by undertaking a detailed neurophysiological investigation of the human vagus nerve and identifying the nerve fibers activated during vagal nerve stimulation, both sensory and motor (including parasympathetic) axons. This may provide a specified range of stimulus intensities required to excite myelinated and unmyelinated nerve fibers in the Clinical Study Protocol as described in the Clinical Core. It will also provide unprecedented detail into the physiology of the human vagus nerve and inform future development of novel intrafascicular neural interfaces.

辅助项目1摘要：来自迷走神经的微电极记录迷走神经是最长的颅神经，在颈部，胸腔和腹部提供了感觉和运动神经支配，包括对心脏，肺，气道和肠道的副交感神经。与交感神经系统不同，在这种神经系统中，可以在人类中直接在人类中进行直接的微电极录音，持续了50年，直到现在，才不可能直接记录副交感神经出口。我们开发了一种超声引导的方法，该方法使我们能够通过插入清醒人的脖子上的微电极直接从迷走神经记录。在这个辅助项目中，我们计划通过对人类迷走神经进行详细的神经生理学研究来基于我们的初步数据，并确定在迷走神经刺激期间激活的神经纤维，包括感觉和运动（包括副交感神经）。如临床核心所述，这可能提供了在临床研究方案中激发髓鞘和无髓神经纤维所需的指定刺激强度。它还将为人类迷走神经的生理学提供前所未有的细节，并为新颖的新型神经界面的未来发展提供信息。