Sex, Hormones and Identity affect Nociceptive Expression (SHINE)

性别、激素和身份影响伤害感受表达 (SHINE)

• 批准号: 10708822
• 负责人: Burel R. Goodin
• 金额: $ 48.26万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-22 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10708822
• 关键词: Address; Advocacy; Affect; Alabama; Appearance; Area; Biological Factors; Blood specimen; Body Image; CD8-Positive T-Lymphocytes; Categories; Cells; Communities; Data; Development; Disease; Disparity; Estradiol; Estrogens; Female; Frequencies; Gender; Gender Identity; Gender Role; Goals; Health; Hormonal; Hormones; Immune; Immune system; Immunologics; Individual; Investigation; Literature; Measures; Mental Depression; Minority Groups; Nociception; Outcome; Pain; Pain Threshold; Participant; Patient Self-Report; Personal Satisfaction; Phenotype; Play; Population; Prejudice; Prevalence; Procedures; Protocols documentation; Psychological Factors; Publishing; Quality of life; Questionnaires; Reporting; Research; Risk; Role; Sensory; Sex Differences; Sleep; Social support; Standardization; Stress; Testing; Testosterone; United States National Institutes of Health; Voice Quality; Vulnerable Populations; Woman; Women' s Health; Work; adverse childhood events; assigned male at birth; chronic pain; cis-female; cis-male; cytokine; experience; genotypic sex; human subject; immunoregulation; innovation; male; man; marginalized community; men; pain sensitivity; perceived discrimination; poor health outcome; pressure; recruit; reproductive hormone; saliva sample; sex; sex assigned at birth; sleep quality; social factors; social stigma; stress reactivity; transgender; transgender men

Sex, Hormones and Identity affect Nociceptive Expression (SHINE)Project Summary It is often reported that females demonstrate lower pain thresholds and higher sensitivity than males in experimental pain tests. However, “sex” and “gender” are often used interchangeably to describe these differences, but genetic sex and gender identity are not always congruent. As a result, human subjects may be categorized as male or female based upon genetic sex even if they do not identify as a man or woman, respectively. Transgender (trans) men and women (TM and TW) are a minority group whose gender identity is different than their genetic sex (as opposed to cisgender men and women; CM and CW). As a result, TM and TW may experience stigma, prejudice and depression, putting them at greater risk for negative health outcomes and impacted quality of life. Thus, this understudied community provides a unique opportunity to investigate the role of gender identity (trans vs. cis), sex assigned at birth (male vs. female) and hormonal status (elevated testosterone vs. elevated estrogen) on pain and well-being, while providing a better understanding of the needs of the community. Specific aims of this study include: 1. To determine the impact of gender identity, sex assigned at birth and hormone status on pain sensitivity. 2. To examine social and psychological factors to contribute to pain sensitivity in our groups. 3.To quantify differences in immune cell populations and activity between our groups. With the assistance of local community stakeholders we will recruit the following groups: CM, CW, TM+T (currently taking exogenous testosterone), TW+E (exogenous estradiol), TM, and TW (n=20/group). We will use quantitative sensory testing to assess sensitivity to cold, pressure, and heat via standardized protocols. Blood samples will be taken for assessment of stress and reproductive hormone levels, immune cell populations and stimulated cytokine release, as well as salivary samples to measure stress reactivity. Finally, questionnaires will measure pain state, quality of life, voice quality of life, body image, appearance, self-reported health, masculinity/femininity, community connectedness, gender role, sleep, depression, social support, adverse childhood experiences and stigma. Together, this will be the first exploration of the impact of gender identity, sex assigned at birth and hormonal status on quality of life, pain sensitivity and immune cell activity in trans individuals. This investigation will also provide critical information with respect to the needs of this underserved and critically understudied population.

性别，激素和身份影响伤害性表达（Shine）项目摘要 经常据报道，女性比男性在 实验疼痛测试。但是，“性别”和“性别”通常可以互换用来形容这些 差异，但是遗传性别和性别认同并不总是一致。结果，人类受试者可能是 即使他们不认定为男人或女人，也将其归类为男性或女性 跨性别者（跨性别）男性和女人（TM和TW）是少数群体，其性别认同是 与他们的遗传性别不同（与cisgender的男人和女人相反； CM和CW）。结果，TM和 两者可能会遭受污名，偏见和抑郁症，使他们面临更大的负面健康状况的风险 并影响了生活质量。这是这个理解的社区提供了一个独特的机会来调查 性别认同的作用（trans vs.顺式），出生时分配的性别（男性与女性）和荷尔蒙身份（升高 睾丸激素与雌激素升高）在疼痛和幸福感方面，同时更好地了解需求 社区。这项研究的具体目的包括：1。确定性别认同的影响，分配的性别 出生时和马酮状态时，疼痛敏感性。 2。检查社会和心理因素以促进 我们小组的疼痛敏感性。 3.量化免疫细胞种群的差异和我们之间的活性 组。在当地社区利益相关者的协助下，我们将招募以下组：CM，CW，TM+T （目前服用外源睾丸激素），TW+E（外源性雌二醇），TM和TW（n = 20/组）。我们将使用 定量感觉测试通过标准化方案评估对寒冷，压力和热量的敏感性。血 样品将用于评估压力和复制激素水平，免疫细胞群体和 刺激细胞因子释放以及唾液样品，以测量应激反应性。最后，问卷会 测量疼痛状态，生活质量，生活质量，身体形象，外观，自我报告的健康， 男性气质/女性气质，社区联系，性别角色，睡眠，抑郁，社会支持，不利 童年的经历和污名。在一起，这将是对性别认同，性影响的第一次探索 在出生时分配和马匹的生活质量，疼痛敏感性和免疫细胞活性 个人。这项投资还将提供有关该服务不足的需求的关键信息 并认识到人口。