Sex, Hormones and Identity affect Nociceptive Expression (SHINE)

性别、激素和身份影响伤害感受表达 (SHINE)

• 批准号: 10708822
• 负责人: Burel R. Goodin
• 金额: $ 48.26万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-22 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10708822
• 关键词: Address; Advocacy; Affect; Alabama; Appearance; Area; Biological Factors; Blood specimen; Body Image; CD8-Positive T-Lymphocytes; Categories; Cells; Communities; Data; Development; Disease; Disparity; Estradiol; Estrogens; Female; Frequencies; Gender; Gender Identity; Gender Role; Goals; Health; Hormonal; Hormones; Immune; Immune system; Immunologics; Individual; Investigation; Literature; Measures; Mental Depression; Minority Groups; Nociception; Outcome; Pain; Pain Threshold; Participant; Patient Self-Report; Personal Satisfaction; Phenotype; Play; Population; Prejudice; Prevalence; Procedures; Protocols documentation; Psychological Factors; Publishing; Quality of life; Questionnaires; Reporting; Research; Risk; Role; Sensory; Sex Differences; Sleep; Social support; Standardization; Stress; Testing; Testosterone; United States National Institutes of Health; Voice Quality; Vulnerable Populations; Woman; Women' s Health; Work; adverse childhood events; assigned male at birth; chronic pain; cis-female; cis-male; cytokine; experience; genotypic sex; human subject; immunoregulation; innovation; male; man; marginalized community; men; pain sensitivity; perceived discrimination; poor health outcome; pressure; recruit; reproductive hormone; saliva sample; sex; sex assigned at birth; sleep quality; social factors; social stigma; stress reactivity; transgender; transgender men

Sex, Hormones and Identity affect Nociceptive Expression (SHINE)Project Summary It is often reported that females demonstrate lower pain thresholds and higher sensitivity than males in experimental pain tests. However, “sex” and “gender” are often used interchangeably to describe these differences, but genetic sex and gender identity are not always congruent. As a result, human subjects may be categorized as male or female based upon genetic sex even if they do not identify as a man or woman, respectively. Transgender (trans) men and women (TM and TW) are a minority group whose gender identity is different than their genetic sex (as opposed to cisgender men and women; CM and CW). As a result, TM and TW may experience stigma, prejudice and depression, putting them at greater risk for negative health outcomes and impacted quality of life. Thus, this understudied community provides a unique opportunity to investigate the role of gender identity (trans vs. cis), sex assigned at birth (male vs. female) and hormonal status (elevated testosterone vs. elevated estrogen) on pain and well-being, while providing a better understanding of the needs of the community. Specific aims of this study include: 1. To determine the impact of gender identity, sex assigned at birth and hormone status on pain sensitivity. 2. To examine social and psychological factors to contribute to pain sensitivity in our groups. 3.To quantify differences in immune cell populations and activity between our groups. With the assistance of local community stakeholders we will recruit the following groups: CM, CW, TM+T (currently taking exogenous testosterone), TW+E (exogenous estradiol), TM, and TW (n=20/group). We will use quantitative sensory testing to assess sensitivity to cold, pressure, and heat via standardized protocols. Blood samples will be taken for assessment of stress and reproductive hormone levels, immune cell populations and stimulated cytokine release, as well as salivary samples to measure stress reactivity. Finally, questionnaires will measure pain state, quality of life, voice quality of life, body image, appearance, self-reported health, masculinity/femininity, community connectedness, gender role, sleep, depression, social support, adverse childhood experiences and stigma. Together, this will be the first exploration of the impact of gender identity, sex assigned at birth and hormonal status on quality of life, pain sensitivity and immune cell activity in trans individuals. This investigation will also provide critical information with respect to the needs of this underserved and critically understudied population.

性别、激素和身份影响伤害感受表达 (SHINE)项目摘要 经常有报道称，女性比男性表现出更低的疼痛阈值和更高的敏感性 实验性疼痛测试。然而，“性”和“性别”经常互换使用来描述这些 差异，但遗传性别和性别认同并不总是一致的。结果，人类受试者可能 根据遗传性别分类为男性或女性，即使他们不认为自己是男性或女性， 分别。跨性别 (trans) 男性和女性（TM 和 TW）是一个少数群体，其性别认同是 不同于他们的遗传性别（与顺性别男性和女性相对；CM 和 CW）。结果，TM 和 台湾人可能会遭受耻辱、偏见和抑郁，使他们面临更大的负面健康结果风险 并影响了生活质量。因此，这个待研究的社区提供了一个独特的机会来调查 性别认同的作用（反式与顺式）、出生时分配的性别（男性与女性）和荷尔蒙状态（升高 睾酮与升高的雌激素）对疼痛和健康的影响，同时提供对需求的更好理解 社区的。本研究的具体目的包括： 1. 确定性别认同、性别分配的影响 出生时和激素状态对疼痛敏感性的影响。 2. 检查社会和心理因素有助于 我们小组的疼痛敏感性。 3.量化我们的免疫细胞群和活性之间的差异 组。在当地社区利益相关者的协助下，我们将招募以下团体：CM、CW、TM+T （目前服用外源性睾酮）、TW+E（外源性雌二醇）、TM 和 TW（n=20/组）。我们将使用 通过标准化方案评估对冷、压力和热的敏感性的定量感官测试。血 将采集样本以评估压力和生殖激素水平、免疫细胞群和 刺激细胞因子释放，以及唾液样本来测量应激反应性。最后，将进行问卷调查 测量疼痛状态、生活质量、声音生活质量、身体形象、外观、自我报告的健康状况、 男性气质/女性气质、社区联系、性别角色、睡眠、抑郁、社会支持、不利 童年经历和耻辱。总之，这将是对性别认同、性别影响的首次探索。 出生时分配的激素状态和跨性别者的生活质量、疼痛敏感性和免疫细胞活性 个人。这项调查还将提供有关这一服务不足的群体的需求的关键信息 和未被充分研究的人群。