Impact of insomnia on substance use in people living with HIV

失眠对艾滋病毒感染者药物使用的影响

• 批准号: 10059153
• 负责人: Burel R. Goodin
• 金额: $ 3.59万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-15 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10059153
• 关键词: Acquired Immunodeficiency Syndrome; Address; Administrative Supplement; Adult; Aging; Agreement; Alabama; Alcohol or Other Drugs use; Alcohols; Anti-Inflammatory Agents; Biological; Biological Markers; Blood; C-reactive protein; Centers for Disease Control and Prevention (U.S.); Circadian Dysregulation; Clinical Research; Clinical Trials; DSM-V; Data; Development; Diagnostic; Discipline of Nursing; Disease; Disease Progression; Faculty; General Population; Genomics; Goals; HIV; Health; Home environment; Individual; Inflammation; Inflammation Mediators; Inflammatory; Inflammatory Response; Interdisciplinary Study; Interleukin-6; International; Interview; Knowledge; Laboratories; Learning; Life; Link; Literature; Manuscripts; Maps; Mediator of activation protein; Medicine; Mission; Neurobiology; Pain; Pain Threshold; Parents; Participant; Patient Self-Report; Peer Review; Persons; Pharmaceutical Preparations; Physical Function; Physiological; Pilot Projects; Polysomnography; Population; Prevalence; Procedures; Process; Public Health; Quality of life; Questionnaires; Recording of previous events; Reporting; Research; Research Design; Research Personnel; Research Priority; Research Training; Resources; Risk Factors; Severities; Sleep; Sleep Deprivation; Sleep Disorders; Sleep disturbances; Sleeplessness; Standardization; Stimulus; Structure; TNF gene; Time; Translational Research; United States National Institutes of Health; Universities; Variant; Vulnerable Populations; actigraphy; associated symptom; base; career; career development; chronic pain; college; comorbidity; comparison group; design; diaries; experience; falls; inflammatory marker; innovation; member; monitoring device; pain sensitivity; pain symptom; parent grant; parent project; physically handicapped; recruit; research and development; response; sleep quality; stressor; symposium; tenure track; therapeutic target; training opportunity; trend

Project Summary/Abstract This administrative supplement, in response to PA-18-906: “Research Supplements to Promote Diversity in Health-Related Research (Admin Supp – Clinical Trial Not Allowed)”, will expand the parent project (R01HL147603, PI-Burel R. Goodin), and provide research and career development support for Dr. Shameka L. Cody, a tenure track junior faculty member at The University of Alabama Capstone College of Nursing in Tuscaloosa, AL. Numerous reports of co-occurring symptoms such as poor sleep quality and pain exist among people living with HIV (PLWH) which can negatively impact quality of life. Insomnia, which is characterized by difficulty falling asleep, staying asleep or both, has been reported among 70% of PLWH compared to less than 35% of the general population. Similar to insomnia, over half of PLWH are likely to experience recurring pain symptoms. Pain is a growing concern for PLWH and has been associated with poor sleep quality. Laboratory- based studies have shown that sleep deprivation is associated with increased inflammatory effects, and these same inflammatory effects are associated with increased pain sensitivity. The parent grant for this Diversity Supplement has been designed to examine the impact of insomnia on pain and pain-related inflammatory processes in PLWH. Substance use is another mechanism by which insomnia may promote pain and inflammatory effects in PLWH. Nearly 50% of PLWH report current or past histories of drug or alcohol disorders. Substance use is associated with increased systematic inflammation, and in PLWH, these effects may be more profound and hasten disease progression. Exploring the impact of insomnia on pain and pain-related inflammatory processes in substance users with HIV will enhance the parent study, and represents an innovative training opportunity for a junior faculty. The scientific goals of the supplement are to: (1) augment the parent study with recruitment of PLWH and substance use, (2) examine whether the impact of insomnia on pain and pain-related processes differ by HIV+ substance users, (3) identify the interaction of substance use and insomnia in predicting increased pain sensitivity and elevated inflammatory biomarker levels (i.e., IL-6, TNF-α, and C- reactive protein). This supplement also has three career development goals for Dr. Cody, a promising junior faculty with a background in Nursing, HIV and aging, and sleep quality: (1) acquire expertise in clinical and translational research training in Sleep Medicine; (2) advance her knowledge of poor sleep quality in PLWH and its effects with substance use on quality of life determinants; (3) learn how to build multidisciplinary research teams, present at national and international conferences, develop first-author peer-reviewed manuscripts, and develop a competitive proposal for an early-career investigator R01.

项目摘要/摘要 这种行政补充是对PA-18-906的回应：“研究补充剂，以促进多样性 与健康有关的研究（Admin Supp - 不允许临床试验）”，将扩大父母项目 （R01HL147603，Pi-Burel R. Goodin），并为Shameka L.博士提供研究和职业发展支持。 科迪（Cody），阿拉巴马大学卡普斯通大学护理学院的任期初级教师 塔斯卡卢萨（Al）。关于同时发生症状（例如睡眠质量和疼痛）的许多报道 患有艾滋病毒（PLWH）的人会对生活质量产生负面影响。失眠，其特征是 据报道，在70％ 35％的普通人群。与失眠类似，超过一半的PLWH可能会经历重复疼痛 症状。疼痛对PLWH越来越关注，与睡眠质量差有关。实验室- 基于的研究表明，睡眠剥夺与炎症作用增加有关，而这些 相同的炎症作用与疼痛敏感性的增加有关。这种多样性的父母赠款 补充剂旨在检查失眠对疼痛和疼痛相关炎症的影响 PLWH中的过程。药物使用是失眠可能促进疼痛和的另一种机制 PLWH中的炎症作用。 PLWH的近50％报告了药物或酒精疾病的当前或过去的历史。 药物使用与系统感染的增加有关，在PLWH中，这些影响可能更多 深刻而急速的疾病进展。探索失眠对疼痛和疼痛有关的影响 患有艾滋病毒的药物使用者的炎症过程将增强父母的研究，并代表创新性 初级教师的培训机会。补充的科学目标是：（1）增强父母 招募PLWH和药物使用的研究，（2）检查失眠对疼痛和 与疼痛相关的过程因HIV+药物使用者而异，（3）确定使用物质和失眠的相互作用 在预测疼痛敏感性增加和炎症生物标志物水平升高时（即IL-6，TNF-α和C- 反应蛋白）。这种补充剂还为科迪博士提供了三个职业发展目标，科迪博士是一个有前途的大三 具有护理，艾滋病毒和老龄化以及睡眠质量背景的教师：（1）获得临床和 睡眠医学的翻译研究培训； （2）提高她对PLWH和 它在物质使用对生活质量的影响决定的影响； （3）学习如何构建多学科研究 在国家和国际会议上出席的团队，制定了由同行评审的第一名作者，以及 为早期研究员R01制定竞争性建议。