Impact of insomnia on substance use in people living with HIV

失眠对艾滋病毒感染者药物使用的影响

• 批准号: 10059153
• 负责人: Burel R. Goodin
• 金额: $ 3.59万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-15 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10059153
• 关键词: Acquired Immunodeficiency Syndrome; Address; Administrative Supplement; Adult; Aging; Agreement; Alabama; Alcohol or Other Drugs use; Alcohols; Anti-Inflammatory Agents; Biological; Biological Markers; Blood; C-reactive protein; Centers for Disease Control and Prevention (U.S.); Circadian Dysregulation; Clinical Research; Clinical Trials; DSM-V; Data; Development; Diagnostic; Discipline of Nursing; Disease; Disease Progression; Faculty; General Population; Genomics; Goals; HIV; Health; Home environment; Individual; Inflammation; Inflammation Mediators; Inflammatory; Inflammatory Response; Interdisciplinary Study; Interleukin-6; International; Interview; Knowledge; Laboratories; Learning; Life; Link; Literature; Manuscripts; Maps; Mediator of activation protein; Medicine; Mission; Neurobiology; Pain; Pain Threshold; Parents; Participant; Patient Self-Report; Peer Review; Persons; Pharmaceutical Preparations; Physical Function; Physiological; Pilot Projects; Polysomnography; Population; Prevalence; Procedures; Process; Public Health; Quality of life; Questionnaires; Recording of previous events; Reporting; Research; Research Design; Research Personnel; Research Priority; Research Training; Resources; Risk Factors; Severities; Sleep; Sleep Deprivation; Sleep Disorders; Sleep disturbances; Sleeplessness; Standardization; Stimulus; Structure; TNF gene; Time; Translational Research; United States National Institutes of Health; Universities; Variant; Vulnerable Populations; actigraphy; associated symptom; base; career; career development; chronic pain; college; comorbidity; comparison group; design; diaries; experience; falls; inflammatory marker; innovation; member; monitoring device; pain sensitivity; pain symptom; parent grant; parent project; physically handicapped; recruit; research and development; response; sleep quality; stressor; symposium; tenure track; therapeutic target; training opportunity; trend

Project Summary/Abstract This administrative supplement, in response to PA-18-906: “Research Supplements to Promote Diversity in Health-Related Research (Admin Supp – Clinical Trial Not Allowed)”, will expand the parent project (R01HL147603, PI-Burel R. Goodin), and provide research and career development support for Dr. Shameka L. Cody, a tenure track junior faculty member at The University of Alabama Capstone College of Nursing in Tuscaloosa, AL. Numerous reports of co-occurring symptoms such as poor sleep quality and pain exist among people living with HIV (PLWH) which can negatively impact quality of life. Insomnia, which is characterized by difficulty falling asleep, staying asleep or both, has been reported among 70% of PLWH compared to less than 35% of the general population. Similar to insomnia, over half of PLWH are likely to experience recurring pain symptoms. Pain is a growing concern for PLWH and has been associated with poor sleep quality. Laboratory- based studies have shown that sleep deprivation is associated with increased inflammatory effects, and these same inflammatory effects are associated with increased pain sensitivity. The parent grant for this Diversity Supplement has been designed to examine the impact of insomnia on pain and pain-related inflammatory processes in PLWH. Substance use is another mechanism by which insomnia may promote pain and inflammatory effects in PLWH. Nearly 50% of PLWH report current or past histories of drug or alcohol disorders. Substance use is associated with increased systematic inflammation, and in PLWH, these effects may be more profound and hasten disease progression. Exploring the impact of insomnia on pain and pain-related inflammatory processes in substance users with HIV will enhance the parent study, and represents an innovative training opportunity for a junior faculty. The scientific goals of the supplement are to: (1) augment the parent study with recruitment of PLWH and substance use, (2) examine whether the impact of insomnia on pain and pain-related processes differ by HIV+ substance users, (3) identify the interaction of substance use and insomnia in predicting increased pain sensitivity and elevated inflammatory biomarker levels (i.e., IL-6, TNF-α, and C- reactive protein). This supplement also has three career development goals for Dr. Cody, a promising junior faculty with a background in Nursing, HIV and aging, and sleep quality: (1) acquire expertise in clinical and translational research training in Sleep Medicine; (2) advance her knowledge of poor sleep quality in PLWH and its effects with substance use on quality of life determinants; (3) learn how to build multidisciplinary research teams, present at national and international conferences, develop first-author peer-reviewed manuscripts, and develop a competitive proposal for an early-career investigator R01.

项目摘要/摘要 本行政副刊是对PA-18-906：“促进多样性的研究副刊”的回应 与健康相关的研究(行政支持-不允许临床试验)“，将扩展父项目 (R01HL147603，Pi-Britl R.Goodin)，并为Shameka L. 科迪是阿拉巴马大学凯普斯通护理学院的终身教职初级教员 亚拉巴马州塔斯卡卢萨许多关于睡眠质量差和疼痛等共生症状的报告存在于 艾滋病毒携带者(PLWH)会对生活质量产生负面影响。失眠，其特征是 据报道，70%的PLWH患者存在入睡困难、睡不着或两者兼而有之的情况，相比之下，这一比例低于 占总人口的35%。与失眠类似，超过一半的PLWH患者可能会经历反复发作的疼痛 症状。疼痛是PLWH日益关注的问题，并与睡眠质量差有关。实验室- 基础研究表明，睡眠不足与炎症效应增加有关，而这些 同样的炎症效应与疼痛敏感度的增加有关。这种多样性的母公司赠款 补充剂的设计是为了检查失眠对疼痛和疼痛相关炎症的影响。 PLWH中的进程。物质使用是失眠可能促进疼痛和 PLWH的炎症效应。近50%的PLWH报告了当前或过去的药物或酒精障碍史。 物质使用与全身炎症增加有关，在PLWH中，这些影响可能更大 影响深远并加速疾病的发展。探讨失眠对疼痛及其相关因素的影响 HIV物质使用者的炎症过程将加强父母的研究，并代表了一种创新 初级教员的培训机会。增刊的科学目的是：(1)增加父母 研究招募PLWH和物质使用，(2)检查失眠对疼痛和 与疼痛相关的过程因HIV+物质使用者的不同而不同，(3)确定物质使用和失眠的相互作用 在预测疼痛敏感性增加和炎性生物标志物水平(即IL-6、肿瘤坏死因子-α和C- 反应蛋白)。本增刊还为科迪博士制定了三个职业发展目标，科迪博士是一名有前途的大三学生 具有护理、艾滋病毒和老龄化以及睡眠质量方面背景的教师：(1)获得临床和睡眠质量方面的专业知识 睡眠医学方面的翻译研究培训；(2)提高她对PLWH睡眠质量差的认识和 物质使用对生活质量决定因素的影响；(3)学习如何建立多学科研究 出席国家和国际会议的小组编写第一作者同行审阅的手稿，以及 为职业生涯早期的调查员R01制定一份有竞争力的提案。