St. Jude Children's Research Hospital - Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Operations and Collaborations Center (UM2 Clinical Trial Optional)

圣裘德儿童研究医院 - 艾滋病毒/艾滋病干预青少年医学试验网络 (ATN) 运营和合作中心（UM2 临床试验可选）

• 批准号: 10709610
• 负责人: Aditya H Gaur
• 金额: $ 45.17万
• 依托单位: WESTAT, INC.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-22 至 2029-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10709610
• 关键词: Academia; Acquired Immunodeficiency Syndrome; Address; Adolescent; Adolescent Medicine; Adolescent Medicine Trials Network; African American population; Age; Area; Arkansas; Behavioral; Black Populations; Cities; Clinic; Clinical; Clinical Research; Clinical Trials; Clinical Trials Design; Collaborations; Communities; County; Development; Diagnosis; Epidemic; Funding; General Population; Geography; HIV; HIV Infections; HIV/AIDS; Health; Healthcare; Human Resources; Income; Individual; Infection; Infrastructure; Intervention; Intervention Studies; Investments; Laboratories; Leadership; Minor; Mississippi; Missouri; Names; Persons; Pharmacy facility; Policies; Population; Poverty; Public Health; Radial; Research Infrastructure; Research Personnel; Risk; Saint Jude Children' s Research Hospital; Schools; Site; Strategic Planning; Tennessee; Therapeutic; Thinking; United States; Universities; Writing; Youth; clinical development; clinical research site; clinical trial implementation; community organizations; community partnership; comorbidity; design; fortification; infection rate; innovation; interest; meetings; metropolitan; microbicide; novel; novel strategies; operation; pandemic disease; prevent; recruit; research facility; rural area; urban area; vaccine trial; virtual

ABSTRACT St. Jude Children's Research Hospital The Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) aims over the 7-year funding cycle to develop and conduct innovative behavioral, community-based, translational, therapeutic, microbicide, and vaccine trials in youth ages 13-24 years at-risk for HIV and living with HIV, with a focus on the inclusion of minors. The ATN seeks investigators with innovative thinking and novel approaches to address the public health issues facing adolescents. The St. Jude Memphis Site Consortium (SMSC), based in Memphis located in the Shelby County of TN has (1) a well-established clinical and clinical research facility at St. Jude Children's Research Hospital (former ATN site), (2) A long-standing Connect to Protect Memphis Coalition (C2P Memphis) of over 25 stakeholders (Community Based organizations, Non for Profit Groups, Memphis Schools, etc.) invested in the interests of youth and (3) established partnerships including with academia (University of Tennessee) and the local Shelby County and Tennessee state health departments. Shelby County is an Ending the HIV Epidemic Priority jurisdiction. The SMSC closely collaborating with the Westat led ATN Operations and Collaborations Center (OCC) will participate in the development of clinical trials and provide the clinical research site(s), local laboratory capacity, and investigational pharmacy support to further the ATN Research agenda. Taking the clinical trials to youth at risk of HIV and those living with HIV who are not aware of their diagnosis will require using innovative approaches for recruitment which the SMSC has demonstrated in the past and looks forward to building on. The C2P Memphis Coalition and a separate youth community advisory board will over the project period be instrumental in providing input both for clinical trial design as well as youth engagement and retention approaches.

圣裘德儿童研究医院 艾滋病毒/艾滋病干预青少年医学试验网络（ATN）的目标是在7年的供资周期内， 开发和开展创新的行为，社区为基础的，转化，治疗，杀微生物剂， 在13-24岁有艾滋病毒感染风险和感染艾滋病毒的青少年中进行疫苗试验，重点是纳入 未成年人ATN寻求具有创新思维和新颖方法的调查人员来解决公众问题 青少年面临的健康问题。位于孟菲斯的圣犹达孟菲斯研究中心联盟（SMSC）位于 在田纳西州谢尔比县有（1）一个完善的临床和临床研究机构在圣裘德儿童医院 研究医院（前ATN网站），（2）一个长期的连接保护孟菲斯联盟（C2 P 孟菲斯）超过25个利益相关者（社区组织，非营利组织，孟菲斯学校， 等等）。投资于青年的利益;（3）建立伙伴关系，包括与学术界（大学） 田纳西州）和当地谢尔比县和田纳西州卫生部门。谢尔比县是一个 终止艾滋病毒流行病优先管辖权。SMSC与Westat领导的ATN密切合作 运营和协作中心（OCC）将参与临床试验的开发，并提供 临床研究中心、当地实验室能力和研究药物支持，以促进ATN 研究议程。对有感染艾滋病毒风险的青年和不知情的艾滋病毒感染者进行临床试验 他们的诊断将需要使用创新的招聘方法， C2 P孟菲斯联盟和一个独立的青年社区 咨询委员会将在项目期间为临床试验设计提供投入 随着青年参与和留住青年的办法越来越多。