St. Jude-Memphis Adolescent Trials Unit

圣裘德-孟菲斯青少年试验中心

• 批准号: 8440210
• 负责人: Aditya H Gaur
• 金额: $ 66.94万
• 依托单位: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-03 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8440210
• 关键词: Adolescent; Adolescent Medicine; Adolescent Medicine Trials Network; Affect; African American; Behavioral; Caring; Clinical Research; Clinical Research Protocols; Clinical Trials; Collaborations; Communities; Comprehensive Health Care; County; Enrollment; Ensure; Environment; Epidemic; HIV; HIV Infections; Health; Human Resources; Human immunodeficiency virus test; Location; Newly Diagnosed; Patient Care; Patients; Prevention; Preventive; Primary Prevention; Principal Investigator; Prophylactic treatment; Protocols documentation; Provider; Research Infrastructure; Research Personnel; Resources; Risk; Saint Jude Children' s Research Hospital; Secondary Prevention; Services; Sexually Transmitted Diseases; Site; Tennessee; United States; Vaccines; Youth; base; clinical care; clinical research site; community organizations; experience; improved; intervention program; microbicide; multidisciplinary; outreach; programs; protocol development; tertiary prevention

DESCRIPTION (provided by applicant): Prevention and treatment efforts in HIV infected or at risk youth require a collaborative effort between clinical research sites with multidisciplinary staff experienced in adolescent medicine, and community organizations such as local health departments, youth service providers, HIV community based organizations and faith based organizations. Such collaboration and a youth friendly environment with creative approaches to successful accrual and retention of youth in clinical studies exist at the St. Jude Memphis Adolescent Trials Unit (ATU). The specific aims of this proposal from a re-competing ATU in Memphis are: 1) To maintain the clinical research infrastructure that supports the Adolescent Medicine Trials Network's (ATN) scientific agenda through the recruitment and retention of HIV-infected and at-risk HIV-uninfected youth into primary, secondary and tertiary prevention studies. 2) To enhance secondary prevention efforts by improving linkage to care of patients newly diagnosed with HIV. 3) To expand and optimize new and existing community linkages that maintain a community-based primary prevention infrastructure that will support HIV preventive biomedical clinical trials, including vaccines, microbicides, pre-exposure prophylaxis and integrated biomedical and behavioral trials. 4) To contribute to the scientific agenda of the Adolescent Medicine Trials Network through the participation of investigators and site personnel in the development of protocols. Memphis, located in the county with the highest sexually transmitted disease rates in Tennessee and with a predominantly black population has been particularly affected by the HIV epidemic. Since its inception in 1987, the St. Jude HIV program has actively participated in clinical research. With 319 enrollments in ATN protocols since joining the network in 2006, the St. Jude Memphis ATU has earned its place as a top performing ATU and looks forward to furthering the ATN scientific agenda in the coming years. Increasing HIV testing amongst youth, improving linkage to care through outreach, and continuing to provide comprehensive care and resources to support engagement and retention in clinical care and research protocols are some of the major components of the St. Jude Memphis ATU's proposed plan. RELEVANCE: In the United States, HIV infection rates are increasing most rapidly among youth, in blacks, and in the South. An intervention program in Memphis, with its location in the South, a predominantly black population, and high STD rates, is poised to have a significant impact on this epidemic. The outstanding comprehensive HIV care and clinical research experience at St. Jude ensure a high-performing program.

描述(申请人提供)：艾滋病毒感染或高危青少年的预防和治疗工作需要临床研究地点与具有青少年医学经验的多学科工作人员与社区组织(如地方卫生部门、青年服务提供者、艾滋病毒社区组织和基于信仰的组织)之间的合作努力。圣裘德·孟菲斯青少年试验中心(ATU)存在这样的合作和对青年友好的环境，采用创造性的方法成功地积累和留住临床研究中的青年。来自孟菲斯重新竞争的ATU的这项建议的具体目的是：1)通过招募和保留感染艾滋病毒的和未感染艾滋病毒的高危青年参加一级、二级和三级预防研究，维护支持青少年医学试验网络(ATN)科学议程的临床研究基础设施。2)加强二级预防工作，改善与新诊断的艾滋病毒感染者护理的联系。3)扩大和优化新的和现有的社区联系，以维持以社区为基础的初级预防基础设施，该基础设施将支持艾滋病毒预防性生物医学临床试验，包括疫苗、杀微生物剂、暴露前预防以及综合生物医学和行为试验。4)通过调查人员和现场人员参与制定方案，为青少年医学试验网络的科学议程作出贡献。孟菲斯位于田纳西州性传播疾病发病率最高的县，人口以黑人为主，尤其受到艾滋病毒疫情的影响。自1987年成立以来，圣裘德艾滋病毒方案一直积极参与临床研究。自2006年加入该网络以来，已有319人注册了ATN协议，圣裘德·孟菲斯ATU已经赢得了表现最好的ATU的地位，并期待着在未来几年进一步推进ATN的科学议程。增加年轻人中的艾滋病毒检测，通过外展改善与护理的联系，以及继续提供全面的护理和资源，以支持参与和保留临床护理和研究方案，是圣裘德孟菲斯ATU拟议计划的一些主要组成部分。 相关性：在美国，青年、黑人和南方的艾滋病毒感染率增长最快。孟菲斯的一项干预计划将对这种流行病产生重大影响。孟菲斯位于南部，人口以黑人为主，性传播疾病发病率很高。圣犹大杰出的全面艾滋病毒护理和临床研究经验确保了项目的高绩效。