Tumor Microenvironment-TME CoBRE

肿瘤微环境-TME CoBRE

• 批准号: 10709266
• 负责人: Paul R Lockman
• 金额: $ 222.21万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10709266
• 关键词: Annual Reports; Apoptosis; Appalachian Region; Area; Atmosphere; Award; Biology; Biometry; Bone Marrow; Bone Marrow Neoplasms; Brain; Breast; Breast Cancer Detection; Budgets; Cell Survival; Cells; Centers of Research Excellence; Cessation of life; Clinical Informatics; Clinical Research; Collaborations; Communication; Core Facility; Cues; Data; Development; Disease; Education; Education and Outreach; Environment; Enzymes; Extramural Activities; Faculty; Faculty Recruitment; Feedback; Flow Cytometry; Foundations; Funding; Gastritis; Genomics; Goals; Grant; Growth; Health Sciences; Helicobacter Infections; Image; Immune system; Immunotherapy; Individual; Infrastructure; Institution; Invaded; Investigation; Investments; Joints; Laboratories; Leucine Zippers; Magnetic Resonance Imaging; Malignant Neoplasms; Measures; Mentors; Multi-Drug Resistance; Multiple Myeloma; Myeloid-derived suppressor cells; National Institute of General Medical Sciences; Neoplasm Metastasis; Organ; Paper; Personal Satisfaction; Phase; Physical environment; Physiological; Pilot Projects; Positioning Attribute; Productivity; Proliferating; Publications; Publishing; Reactive Oxygen Species; Research; Research Infrastructure; Research Personnel; Research Support; Resources; Role; Schools; Scientist; Signal Transduction; Stomach; Students; System; Teacher Professional Development; Techniques; Technology; Time; Tissues; Training; Translational Research; Tumor Suppression; Universities; West Virginia; Workforce Development; cancer cell; cancer initiation; career; career life balance; clinical translation; course development; defined contribution; directional cell; gastric carcinogenesis; health disparity; imaging agent; improved; irradiation; meetings; melanoma; member; microCT; mortality; neoplastic cell; neutrophil; novel therapeutic intervention; outreach program; pancreatic neoplasm; peer; pre-clinical; programs; recruit; response; single cell analysis; success; training opportunity; transcription factor; tumor; tumor growth; tumor microenvironment; tumor progression; tumor-immune system interactions; undergraduate student

PROJECT SUMMARY/ABSTRACT The efforts described in this second phase CoBRE application will support the Center of Excellence within the West Virginia University Health Sciences Center (WVU HSC) that focuses on studies of the tumor microenvironment (TME), designated the TME CoBRE. The overarching critical need for continued emphasis in this area is driven, in part, by that fact that cancer mortality is a significant health disparity in the Appalachian region, specifically in West Virginia. We are building on a successful Phase I, where we had two graduates with R01s, a major national foundation grant, a NSF grant, an R21 and our cores were awarded two S10 awards. In total we had 11 Project Leader (PL) awards as PI, and 8 as a Co-I. The Center has grown to over 20 faculty, including a number of faculty who are potential PLs, with their teams publishing over 140 papers since initiation of Phase I. Laboratories supported, in part, by the Phase I TME CoBRE, have engaged in the training of ~60 students further amplifying the impact of the NIGMS investment on workforce development in parallel to CoBRE PL success. Herein, we provide details for the strategy to continue to develop careers of promising junior scientists and recruit additional investigators to study the biology of, and novel therapeutic approaches that will benefit from, a mechanistic understanding of the diverse TME. The five highly translational projects in Phase II focus on the microenvironment of different tumor types, including cancers initiating in the bone marrow, gastric system, breast, and brain. The administrative core will manage the overall budget and provide assistance in annual reporting and submission of extramural applications of all CoBRE Project Leaders. In addition, this core will provide oversight of mentoring, which includes two primary advisors for each investigator as well as an external advisor, and a network of previous CoBRE graduates and the Director of Core Resources. The investigators will be supported by two research cores that leverage past and current CoBRE and IDeA support. Single cell analysis capability in the existing flow cytometry core will aid to it investigations into genomics of single cells. The Imaging Core will support PLs with cutting edge technologies including microbeam irradiation, microCT, pre-clinical MRI, and real time microenvironment imaging of pO2 and pH. Lastly, we will continue to administer a pilot project program to recruit new junior faculty to the TME CoBRE, as we saw five of six pilot grant awardees eventually become PLs, and we currently have a robust number of junior investigators (#5) may become PLs as well. The investigators are well integrated into established programmatic areas in the West Virginia University Cancer Institute that meet every other month for focused discussion on therapies that leverage, and the biology of, the TME. The mentoring atmosphere, core facilities, and significant institutional support that are central to this effort will continue to provide a rich environment to nurture investigator independence and success around the critical scientific area of TME.

项目总结/文摘

项目成果

Pitavastatin Is Anti-Leukemic in a Bone Marrow Microenvironment Model of B-Lineage Acute Lymphoblastic Leukemia.

Pitavastatin是B-Linege急性淋巴细胞白血病的骨髓微环境模型中的抗白血病。

• DOI: 10.3390/cancers14112681
• 发表时间: 2022-05-28
• 期刊: CANCERS
• 影响因子: 5.2
• 作者: Piktel, Debbie;Nair, Rajesh R.;Rellick, Stephanie L.;Geldenhuys, Werner J.;Martin, Karen H.;Craig, Michael D.;Gibson, Laura F.
• 通讯作者: Gibson, Laura F.

Mesenchymal COX2-PG secretome engages NR4A-WNT signalling axis in haematopoietic progenitors to suppress anti-leukaemia immunity.

间充质Cox2-PG分粒子与造血祖细胞中的NR4A-WNT信号轴接合，以抑制抗leukaemia的免疫力。

• DOI: 10.1111/bjh.15548
• 发表时间: 2018-11
• 期刊: British journal of haematology
• 影响因子: 6.5
• 作者: Wu L;Amarachintha S;Xu J;Oley F Jr;Du W
• 通讯作者: Du W

Interphotoreceptor matrix proteoglycans IMPG1 and IMPG2 proteolyze in the SEA domain and reveal localization mutual dependency.

• DOI: 10.1038/s41598-022-19910-1
• 发表时间: 2022-09-15
• 期刊: SCIENTIFIC REPORTS
• 影响因子: 4.6
• 作者: Mitchell, Benjamin;Coulter, Chloe;Geldenhuys, Werner J.;Rhodes, Scott;Salido, Ezequiel M.
• 通讯作者: Salido, Ezequiel M.

Symbiosis preservation: Putative regulation of fatty acyl-CoA reductase by miR-31a within the symbiont harboring bacteriome through tsetse evolution.

• DOI: 10.3389/fmicb.2023.1151319
• 发表时间: 2023
• 期刊: Frontiers in microbiology
• 影响因子: 5.2

Interleukin-27 impairs BCG antigen clearance and T cell stimulatory potential by neonatal dendritic cells.

• DOI: 10.1016/j.crmicr.2022.100176
• 发表时间: 2023
• 期刊: CURRENT RESEARCH IN MICROBIAL SCIENCES
• 作者: Bradford, Shelby D.;Witt, Michelle R.;Povroznik, Jessica M.;Robinson, Cory M.
• 通讯作者: Robinson, Cory M.