FIRCA Breast Cancer Case-Control Study in Slovakia

描述（由申请人提供） 这项研究将主要在斯洛伐克进行，作为NIH资助# P01 CA 82267（项目4）的FIRCA补充。乳腺癌是最常见的癌症在妇女的SIovakia，和死亡的主要原因。有新的数据表明，胎儿、幼儿和青少年与生长、体重和体力活动有关的暴露可能与乳腺癌风险有关。我们建议在斯洛伐克西部的一项以医院为基础的病例对照研究中评估这些问题。病例（N=250）为2003年1月1日至2005年6月30日首次诊断为浸润性乳腺癌的20-70岁女性，诊断时为特尔纳瓦或塞尼卡区居民。将通过对特尔纳瓦和塞尼卡地区医院的监测迅速查明病例。对照组（N=250）为无乳腺癌病史的女性，年龄20-70岁，居住在特尔纳瓦或塞尼卡区。对照组将按年龄组和地区与病例频率匹配，并将从每个地区的初级保健医疗实践中随机选择。参与者将完成标准化的面对面访谈并提供血液样本。通过访谈和提取医疗/人口记录，我们将收集有关胎儿暴露的数据（出生体重、出生身长、胎龄、双胞胎/卵性、先兆子痫等），儿童期人体测量（不同年龄的身高和体重）和青少年期暴露（人体测量，初潮年龄）。我们还将收集其他关键乳腺癌风险因素的数据，包括生殖和成人人体测量变量，以评估混杂因素。还将从外周血中收集基因组DNA，并储存起来，以进行未来关于候选基因中常见遗传多态性以及基因-环境相互作用在乳腺癌病因学中的作用的研究。有足够的统计功效来检验感兴趣的先验假设。我们为这项研究组建了一个国际研究小组。这项研究将解决乳腺癌病因学中的一个重要科学问题，预计这些数据将更好地为该疾病的一级预防提供信息。这项研究还将在斯洛伐克发展进行癌症流行病学研究的基础设施和经验，并为扩大这项研究工作提供必要的初步数据。

DESCRIPTION (provided by applicant) This research will be done primarily in Slovakia as a FIRCA supplement to NIH grant # P01 CA82267 (Project 4). Breast cancer is the most commonly diagnosed cancer in women in SIovakia, and the leading cause of death. There are emerging data that fetal, early childhood and adolescent exposures related to growth, body mass and physical activity may be associated with the risk of breast cancer. We propose to evaluate these questions in a hospital-based case-control study in western Slovakia. Cases (N=250) will be women aged 20-70 years who are first diagnosed with invasive breast cancer from 1/1/2003 through 6/30/2005 and are residents of Trnava or Senica districts at the time of diagnosis. Cases will be rapidly ascertained through surveillance of the district hospitals in Trnava and Senica. Controls (N=250) will be women with no history of breast cancer, aged 20-70 years, and who are residents of Trnava or Senica district. Controls will be frequency matched to cases by age group and district, and will be randomly selected from the primary care medical practices in each district. Participants will complete a standardized in-person interview and provide a blood sample. Through interviews and abstraction of medical/population records, we will collect data on fetal exposures (birthweight, birth length, gestational age, twinning/zygosity, pre-eclampsia, etc.), childhood anthropometrics (height and weight at various ages), and adolescent exposures (anthropometrics, age at menarche). We will also collect data on other key breast cancer risk factors, including reproductive and adult anthropometric variables, in order to evaluate confounding. Genomic DNA will also be collected from peripheral blood, and banked in order to conduct future studies on the role of common genetic polymorphisms in candidate genes, as well as gene-environment interactions, in the etiology of breast cancer. There is sufficient statistical power to test the a priori hypotheses of interest. We have assembled an international research team for this study. This study will address an important scientific question in breast cancer etiology, and these data would be expected to better inform the primary prevention of the disease. This study will also develop infrastructure and experience in Slovakia for the conduct of cancer epidemiology studies, and generate the necessary preliminary data for expansion of this research effort.