FIRCA Breast Cancer Case-Control Study in Slovakia

斯洛伐克 FIRCA 乳腺癌病例对照研究

• 批准号: 6699969
• 负责人: JAMES R CERHAN
• 金额: $ 3.46万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-02-01 至 2006-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6699969
• 关键词: FIRCA; Breast; Cancer; Case; Control

DESCRIPTION (provided by applicant) This research will be done primarily in Slovakia as a FIRCA supplement to NIH grant # P01 CA82267 (Project 4). Breast cancer is the most commonly diagnosed cancer in women in SIovakia, and the leading cause of death. There are emerging data that fetal, early childhood and adolescent exposures related to growth, body mass and physical activity may be associated with the risk of breast cancer. We propose to evaluate these questions in a hospital-based case-control study in western Slovakia. Cases (N=250) will be women aged 20-70 years who are first diagnosed with invasive breast cancer from 1/1/2003 through 6/30/2005 and are residents of Trnava or Senica districts at the time of diagnosis. Cases will be rapidly ascertained through surveillance of the district hospitals in Trnava and Senica. Controls (N=250) will be women with no history of breast cancer, aged 20-70 years, and who are residents of Trnava or Senica district. Controls will be frequency matched to cases by age group and district, and will be randomly selected from the primary care medical practices in each district. Participants will complete a standardized in-person interview and provide a blood sample. Through interviews and abstraction of medical/population records, we will collect data on fetal exposures (birthweight, birth length, gestational age, twinning/zygosity, pre-eclampsia, etc.), childhood anthropometrics (height and weight at various ages), and adolescent exposures (anthropometrics, age at menarche). We will also collect data on other key breast cancer risk factors, including reproductive and adult anthropometric variables, in order to evaluate confounding. Genomic DNA will also be collected from peripheral blood, and banked in order to conduct future studies on the role of common genetic polymorphisms in candidate genes, as well as gene-environment interactions, in the etiology of breast cancer. There is sufficient statistical power to test the a priori hypotheses of interest. We have assembled an international research team for this study. This study will address an important scientific question in breast cancer etiology, and these data would be expected to better inform the primary prevention of the disease. This study will also develop infrastructure and experience in Slovakia for the conduct of cancer epidemiology studies, and generate the necessary preliminary data for expansion of this research effort.

描述（由申请人提供） 这项研究将主要在斯洛伐克进行，作为 NIH 拨款 # P01 CA82267（项目 4）的 FIRCA 补充。乳腺癌是西洛伐克女性最常诊断出的癌症，也是导致死亡的主要原因。新的数据表明，胎儿、幼儿和青少年与生长、体重和体力活动相关的暴露可能与乳腺癌风险相关。我们建议在斯洛伐克西部进行的一项基于医院的病例对照研究中评估这些问题。病例（N = 250）是20-70岁的女性，她们在2003年1月1日至2005年6月30日期间首次被诊断患有浸润性乳腺癌，并且在诊断时是特尔纳瓦或塞尼察地区的居民。将通过对特尔纳瓦和塞尼察地区医院的监测来迅速查明病例。对照 (N=250) 是没有乳腺癌病史、年龄 20-70 岁、特尔纳瓦或塞尼察区居民的女性。对照将按年龄组和地区与病例进行频率匹配，并将从每个地区的初级保健医疗机构中随机选择。参与者将完成标准化的面对面访谈并提供血液样本。通过访谈和提取医疗/人口记录，我们将收集胎儿暴露数据（出生体重、出生身长、胎龄、双胞胎/合子、先兆子痫等）、儿童人体测量数据（不同年龄段的身高和体重）和青少年暴露数据（人体测量数据、初潮年龄）。我们还将收集其他关键乳腺癌风险因素的数据，包括生殖和成人人体测量变量，以评估混杂因素。还将从外周血中收集基因组 DNA 并储存起来，以便将来研究候选基因中常见遗传多态性的作用以及基因与环境的相互作用在乳腺癌病因学中的作用。有足够的统计功效来检验感兴趣的先验假设。我们为这项研究组建了一个国际研究团队。这项研究将解决乳腺癌病因学中的一个重要科学问题，这些数据有望更好地为该疾病的一级预防提供信息。这项研究还将开发斯洛伐克进行癌症流行病学研究的基础设施和经验，并为扩大这项研究工作生成必要的初步数据。