NERVOUS SYSTEM DEVELOPMENT AND INJURY

描述（由申请人提供） 本申请寻求继续资助两个培训项目 华盛顿大学是一所由美国政府联合管理的大学 过去 19 年的神经内科和神经外科科室，以及 另一个由小儿神经内科管理 过去八年。后者，神经科学学术 发展奖不可续签。我们寻求提供一个扩展的计划 为选定的神经病学、神经外科或神经病学培训人员提供研究培训 小儿神经病学，为学术生涯做准备。为了利用 近几年来，我们在转化神经科学研究方面取得了进展 我们的培训计划更加强调以患者为中心 研究。因此，我们打算加强对基准研究的历史重视 通过为我们的学员提供接受严格教育的机会 临床研究方法。 我们相信临床的下一步进展 神经病学和神经外科将由研究人员付诸实践 在这种方法中将临床专业知识与正规教育结合起来。实习生 参加我们的培训计划预计将投入至少两个 除了住院医师培训之外，还花费了数年近乎全职的努力来完成这项任务。这是 可能是培养经过科学训练的人员所需的最短时间 神经病学或神经外科临床医生对于阐明这一点至关重要 神经系统疾病的发病机制，并为神经系统疾病带来新的治疗方法 患者。尽管神经科学研究不断取得进展，但 目前神经内科或神经外科的人才严重短缺 有能力执行这些任务的医师科学家或临床研究人员 基本的翻译功能。事实上，美国神经病学 协会目前列出了 150 多个学术神经病学领域的空缺职位 独自一人。 利用培训单位本身的现有优势 （神经病学、神经外科和小儿神经病学），以及更大的范围内 华盛顿大学神经科学界，拟议的计划将 继续关注两大主题：神经系统损伤和神经系统损伤 系统开发。这些孪生主题是疾病相关领域的活跃前沿 当今的神经科学，与理解许多疾病的发病机制有关 不同的神经系统疾病。这些主题是互补的，而且 部分重叠。对发展中本质的洞察 神经系统很可能与理解神经系统相关 对伤害的反应。

DESCRIPTION (provided by applicant) The present application seeks continued funding for two training programs at Washington University, one that has been jointly administered by the Departments of Neurology and Neurological Surgery for the past 19 years, and another that has been administered by the Division of Pediatric Neurology for the past eight years. The latter, the Neurological Sciences Academic Development Award, cannot be renewed. We seek to provide a program of extended research training for selected trainees in Neurology, Neurosurgery, or Pediatric Neurology, preparing for academic careers. To take advantage of progress in translational neuroscience research over the last few years, we have increased the emphasis of our training program on patient-oriented research. We thus intend to augment our historical emphasis on bench research by offering our trainees the opportunity to gain a rigorous education in clinical research methodology. We believe that the next advances in clinical neurology and neurosurgery will be brought into practice by investigators who combine clinical expertise with formal education in this methodology. Trainees participating in our training program will be expected to devote at least two years of near full-time effort beyond residency training to the task. This is likely the minimum period necessary to develop the scientifically-trained neurological or neurosurgical clinicians who will be essential for elucidating the pathogenesis of nervous system diseases, and bringing new therapies to patients. Despite accelerating neuroscience research advances, there is presently a serious shortage of neurological or neurosurgical physician-scientists or clinical researchers capable of performing these essential translational functions. Indeed, the American Neurological Association currently lists over 150 open positions in academic neurology alone. Exploiting current strengths, both within the training units themselves (Neurology, Neurosurgery, and Pediatric Neurology), and within the larger neuroscience community at Washington University, the proposed program will continue to focus on two major themes: Nervous System Injury, and Nervous System Development. These twin themes are active fronts in disease-related neuroscience today, relevant to understanding the pathogenesis of many different neurological diseases. These themes are complementary, as well as partially overlapping. Insights gained into the nature of the developing nervous system are highly likely to be relevant to understanding nervous system responses to injury.