Mechanisms responsible for neurogenic hypertension: a novel interaction between GABAergic modulation of amygdalo-hypothalamic pathways and microRNA regulation of renin

神经源性高血压的机制：杏仁核-下丘脑通路的 GABA 能调节与肾素的 microRNA 调节之间的新型相互作用

• 批准号: nhmrc : 1091688
• 金额: $ 22.69万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-responsible-neurogenic-regulation-renin/519342
• 关键词: Mechanisms; responsible; neurogenic; hypertension; novel

A genetic model of hypertension will be used to understand the interrelated role of the brain, nervous system and kidney. The proposed studies will test the hypothesis that disruption of inhibitory neurochemicals in specific regions of the brain, leads to greater nervous system activation of the kidney, which in turn decreases an inhibitory molecule, ultimately resulting in greater activation of a hormonal system responsible for raising blood pressure.

高血压的遗传模型将用于了解大脑，神经系统和肾脏的相互作用。拟议的研究将测试这样一种假设，即大脑特定区域中抑制性神经化学物质的破坏会导致肾脏神经系统的更大激活，从而减少抑制性分子，最终导致负责升高血压的激素系统的更大激活。