Mechanisms responsible for neurogenic hypertension: Role of a novel interaction between amygdala-hypothalamic GABA pathways and the microRNA regulation of renin

神经源性高血压的机制：杏仁核-下丘脑 GABA 通路与肾素 microRNA 调节之间新型相互作用的作用

• 批准号: nhmrc : 1065714
• 负责人: Dr Francine Marques
• 金额: $ 38.44万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-responsible-neurogenic-regulation-renin/455192
• 关键词: Mechanisms; responsible; neurogenic; hypertension; Role

We identified that mice bred to have high blood pressure (hypertension) have an overactive nervous system due to a faulty molecule in a small region of the brain that controls emotion and the response to stress. The high nervous activity affects a hormone in the kidney that may lead to hypertension. The proposal will determine the mechanisms and neurochemicals in the brain that are responsible for magnifying the responses to stress leading to hypertension and test a new therapy to treat high blood pressure.

我们发现，被培育成患有高血压(高血压)的小鼠的神经系统过度活跃，这是由于大脑小区域中控制情绪和对压力的反应的一个错误分子造成的。高度的神经活动会影响肾脏中的一种荷尔蒙，这可能会导致高血压。该提案将确定大脑中导致高血压的压力反应放大的机制和神经化学物质，并测试一种治疗高血压的新疗法。