Mechanisms responsible for neurogenic hypertension: a novel interaction between GABAergic modulation of amygdalo-hypothalamic pathways and microRNA regulation of renin

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A genetic model of hypertension will be used to understand the interrelated role of the brain, nervous system and kidney. The proposed studies will test the hypothesis that disruption of inhibitory neurochemicals in specific regions of the brain, leads to greater nervous system activation of the kidney, which in turn decreases an inhibitory molecule, ultimately resulting in greater activation of a hormonal system responsible for raising blood pressure.