ENVIRONMENTAL INFLUENCES AND DENTAL CARIES

环境影响和龋齿

• 批准号: 6695652
• 负责人: WILLIAM H BOWEN
• 金额: $ 82.41万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6695652
• 关键词: dental caries; dental plaque; environmental health; oral health

Despite significant reduction in the prevalence of dental caries in some segments of the population it remains a major public health problem, particularly for those least able to bear the burden. The decline in prevalence has generally been attributed to increased exposure to fluoride through a variety of routes. Prior to and during the increased use of fluorides ingestion with food preservatives was also increasing by over 25 fold. Food preservatives have properties in common with fluoride in that they behave as weak acids they are protonated at low pH values, can diffuse into cells, reduce acid tolerance and acid adaptation by mutants streptococci. Recognizing the importance of saliva on the plaque environment, we will examine the relationship of mammalian and non- mammalian components of whole saliva samples collected over a three- year period, to the incidence of dental caries in the same group of subjects. We believe this proposal is highly novel and offers the possibility of developing approaches to enhance the diagnosis of caries and methods for its prevention.

尽管龋齿在某些人群中的流行率显著下降，但它仍然是一个主要的公共卫生问题，特别是对那些最不能承受负担的人来说。流行率的下降一般归因于通过各种途径接触氟化物的增加。在增加使用氟化物和食品防腐剂之前和期间，摄入量也增加了25倍以上。食品防腐剂与氟化物具有共同的特性，因为它们表现为弱酸，它们在低pH值下质子化，可以扩散到细胞中，降低突变链球菌的酸耐受性和酸适应性。认识到唾液对牙菌斑环境的重要性，我们将研究三年内收集的整个唾液样本中哺乳动物和非哺乳动物成分与同一组受试者龋齿发病率的关系。 我们相信这一建议是非常新颖的，并提供了发展的方法，以加强龋齿的诊断和预防方法的可能性。

项目成果

Mechanisms of inhibition by fluoride of urease activities of cell suspensions and biofilms of Staphylococcus epidermidis, Streptococcus salivarius, Actinomyces naeslundii and of dental plaque.

氟化物抑制表皮葡萄球菌、唾液链球菌、内氏放线菌和牙菌斑细胞悬浮液和生物膜脲酶活性的机制。

• DOI: 10.1111/j.1399-302x.2005.00228.x
• 发表时间: 2005
• 期刊: Oral microbiology and immunology.
• 作者: Barboza-Silva,E;Castro,ACD;Marquis,RE
• 通讯作者: Marquis,RE

Membrane locus and pH sensitivity of paraben inhibition of alkali production by oral streptococci.

对羟基苯甲酸酯抑制口腔链球菌产碱的膜位点和 pH 敏感性。

• DOI: 10.1034/j.1399-302x.1999.140408.x
• 发表时间: 1999
• 期刊: Oral microbiology and immunology
• 作者: Ma,Y;Rutherford,GC;Curran,TM;Reidmiller,JS;Marquis,RE
• 通讯作者: Marquis,RE

The effect of chronic clonidine administration on salivary glands and caries in the rat.

长期服用可乐定对大鼠唾液腺和龋齿的影响。

• DOI: 10.1159/000016589
• 发表时间: 2000
• 期刊: Caries research
• 影响因子: 4.2
• 作者: Watson,GE;Pearson,SK;Bowen,WH
• 通讯作者: Bowen,WH

Physiologic homeostasis and stress responses in oral biofilms.

口腔生物膜的生理稳态和应激反应。

• DOI: 10.1016/s0076-6879(99)10035-1
• 发表时间: 1999
• 期刊: Methods in enzymology
• 作者: Burne,RA;QuiveyJr,RG;Marquis,RE
• 通讯作者: Marquis,RE

Selective sensitization of bacteria to peroxide damage associated with fluoride inhibition of catalase and pseudocatalase.

细菌对过氧化氢损伤的选择性敏感性与氟化物对过氧化氢酶和假过氧化氢酶的抑制有关。

• DOI: 10.1034/j.1399-302x.2001.160105.x
• 发表时间: 2001
• 期刊: Oral microbiology and immunology
• 作者: Phan,TN;Kirsch,AM;Marquis,RE
• 通讯作者: Marquis,RE