Role Of Energy Expenditure And Food Intake In Body Weigh

该项目的主要目的是研究人类能量消耗和能量摄入的调节，并确定儿童和成人体重增加的代谢危险因素。为了评估静息能量消耗，我们使用间接量热法（代谢车和呼吸室）。为了评估自由生活条件下的能量消耗，我们使用双标签水（DWL）。为了评估能量摄入和饮食行为，我们使用了食物频率调查问卷、自动售货机和味觉测试。为了确定饥饿，味觉和饱腹感的神经解剖学相关性，我们使用正电子发射断层扫描（PET）。在过去的一年中，我们将体育活动水平（PAL）的遗传力研究扩大到100对双胞胎；b)完成了一项合作研究，以验证35名使用DLW的美洲原住民儿童的饮食和PAL问卷（目前正在分析数据）；C)继续研究糖尿病母亲青春期前后代的饮食行为特征；d)继续研究皮马族成年兄弟姐妹的饮食行为特征（正在进行中）；e)对患有Prader-Willi综合征的个体进行PET研究（正在进行中）

The main aim of this project is to study the regulation of energy expenditure and energy intake in humans and identify metabolic risk factors of weight gain in children and adults. To assess resting energy expenditure we use indirect calorimetry (metabolic carts and respiratory chamber). To assess energy expenditure in free-living condition we use doubly labeled water DWL). To assess energy intake and eating behavior we use food frequency questionnaires, vending machines, and taste tests. To determine the neuroanatomical correlates of hunger, taste and satiation we use positron emission tomography (PET). In the past year we have: a) expanded the study of the heritability of physical activity level (PAL) to 100 pairs of twins; b) completed a collaborative study to validate diet and PAL questionnaires in 35 Native American children using DLW (data currently being analyzed); c) continued a study to characterize eating behavior in pre-pubertal offspring of diabetic mothers; d) continued a study to characterize eating behavior in adult Pima siblings (ongoing); e) conducted a PET study in individuals with Prader-Willi syndrome (ongoing)