Autonomic Nervous System And Energy Metabolism In Humans

本项目的主要目的是研究自主神经系统在能量代谢调节中的作用及其在肥胖和2型糖尿病的病理生理学中的可能贡献。我们使用显微神经图来测量肌肉交感神经活动(MSNA)，并使用血浆/尿儿茶酚胺来测量全局交感神经系统(SNS)的活动。我们使用空腹和餐后胰多肽、瞳孔测量、心率/血压测试和胃排空率来评估副交感神经系统(PNS)的活动。在过去的一年里，我们已经：a)证实抑制皮质醇并不能改善皮马和高加索人减少的MSNA；b)发起了一项合作研究，以评估皮马人和高加索人中皮质醇敏感性的组织特异性调节剂11-β-HSD活性的可能差异；c)继续研究PNS在皮马人和高加索人胰岛素分泌功能中的作用；d)启动了一项关于皮马人和高加索人对标准膳食的SNS反应的研究

The main aim of this project is to study the role of the autonomic nervous system in the regulation of energy metabolism and its possible contribution to the pathophysiology of obesity and type 2 diabetes. We use microneurography to measure muscle sympathetic nerve activity (MSNA) and plasma/urine catecholamines to measure global sympathetic nervous system (SNS) activity. We use fasting and post-prandial pancreatic polypeptide, pupillometry, heart rate/blood pressure tests, and gastric emptying rate to assess parasympathetic nervous system (PNS) activity. In the past year we have: a)established that suppression of cortisol does not improve the reduced MSNA in Pimas b)initiated a collaborative study to assess possible differences in 11-beta-HSD activity, a tissue specific modulator of cortisol sensitivity, in Pimas and Caucasians; c)continued a study on the role of PNS in insulin secretory function in Pimas and Caucasians; d)initiated a study on the SNS response to a standard meal in Pimas and Caucasians