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Mouse Model--targeted Gene Knock-out Of Prostaglandin Sy

Mouse Model--targeted Gene Knock-out Of Prostaglandin Sy
小鼠模型--前列腺素sy基因靶向敲除
批准号：
6681841
负责人：
Robert Langenbach
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6681841
关键词：
congenital cardiovascular shunt disease /disorder model gene expression gene targeting genetic carriers genetically modified animals heart contraction laboratory mouse lethal genes patent ductus arteriosus prostaglandin endoperoxide synthase protein isoforms protein protein interaction protein structure function vascular smooth muscle

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Summary of Work: Mice deficient in both COX-1 and COX-2 have been produced. These mice are being used to determine the physiological roles of the individual COX isoforms and to elucidate the ways in which the two isoforms act individually or in conjunction. Mice deficient in both isoforms die shortly after birth of patent ductus arteriosus, but otherwise appear developmentally normal. We have found that COX-2 is the isoform primarily responsible for the closure of the ductus and that COX-2, but not COX-1, is induced in the contracting smooth mucles of the ductus. In further studies, we have demonstrated that COX-1 or COX-2 selective inhibitors duplicate the results obtained with the COC knockout mice.
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