Tea's effect on atherosclerosis pilot study

茶对动脉粥样硬化影响的初步研究

• 批准号: 6824157
• 负责人: MURRAY A MITTLEMAN
• 金额: $ 25.5万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6824157
• 关键词: affinity chromatography; aorta; atherosclerosis; atherosclerotic plaque; cardiovascular disorder risk; cardiovascular imaging /visualization; chemoprevention; clinical research; diet therapy; flavonoids; human old age (65+); human subject; human therapy evaluation; low density lipoprotein; magnetic resonance imaging; patient oriented research; tea; urinalysis; vascular endothelium; very low density lipoprotein

DESCRIPTION (provided by applicant): Tea is widely thought to have health benefits, particularly on cardiovascular disease (CVD). Our group recently found that intake of 2 or more cups of tea per day was associated with a 44% lower long-term mortality rate than abstention from tea among 1900 patients hospitalized with myocardial infarction. Short-term trials support a benefit of tea on endothelial function, but long-term randomized trials of tea intake on CVD and atherosclerosis are needed to test the effects of tea definitively. We propose a proof-of-principle pilot study of the effect of long-term tea intake on atherosclerosis. From a large hospital-based primary care practice, we will recruit and randomize 30 patients at high risk for CVD to a six-month period of consumption of 3 cups per day of either tea, supplied as black tea solids readily dissolved in hot or cold liquid, or water. We will confirm the polyphenol content of these solids at baseline, and use a single batch of tea throughout the study. At baseline and after 6 months, we will assess aortic atherosclerosis using magnetic resonance imaging, an accurate and reproducible method for measurement of arterial plaque size. We will measure adherence using urinary catechins, the primary flavonoids in tea. The primary outcomes will be compliance with tea intake and 2 MRI examinations. As secondary outcomes, we will measure standard and novel cardiovascular risk markers, including inflammatory, prothrombotic, fibrinolytic, and metabolic factors. We will also assess the effects of tea consumption on oxidizability of LDL and VLDL cholesterol, using a novel affinity-column chromatography approach, on oxidative damage to DNA, and on endothelial integrity, as assessed by serum markers of endothelial function. If successful, this pilot study will form the basis for a larger, long-term randomized trial to determine the effect of tea consumption on progression of atherosclerosis.

描述（由申请人提供）：茶被广泛认为具有健康益处，特别是对心血管疾病（CVD）。 我们的研究小组最近发现，在1900名因心肌梗死住院的患者中，每天摄入2杯或更多的茶与长期死亡率降低44%有关。 短期试验支持茶对内皮功能的益处，但需要长期随机试验茶摄入量对心血管疾病和动脉粥样硬化的影响，以明确测试茶的影响。 我们提出了一项关于长期喝茶对动脉粥样硬化影响的原理验证性初步研究。 从一家大型医院的初级保健实践中，我们将招募并随机分配30名CVD高风险患者，每天饮用3杯茶，以红茶固体形式提供，易于溶解在热或冷液体中，或水。 我们将确认这些固体的多酚含量在基线，并在整个研究中使用一批茶。 在基线和6个月后，我们将使用磁共振成像评估主动脉粥样硬化，磁共振成像是测量动脉斑块大小的准确和可重复的方法。 我们将使用尿中的儿茶素（茶中主要的类黄酮）来测量坚持性。 主要结果将是茶摄入量和2次MRI检查的依从性。 作为次要结局，我们将测量标准和新的心血管风险标志物，包括炎症、促血栓形成、纤溶和代谢因子。 我们还将评估茶叶消费对LDL和VLDL胆固醇的氧化能力的影响，使用一种新的亲和柱色谱法，对DNA的氧化损伤，并对内皮完整性，评估内皮功能的血清标志物。 如果成功，这项初步研究将为一项更大的长期随机试验奠定基础，以确定喝茶对动脉粥样硬化进展的影响。