Biomolecular Profilometer

生物分子轮廓仪

• 批准号: 6831957
• 负责人: CURTIS L MOSHER
• 金额: $ 20万
• 依托单位: BIOFORCE NANOSCIENCES, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6831957
• 关键词: bioassay; bioengineering /biomedical engineering; biomedical equipment development; biosensor device; computer program /software; imaging /visualization /scanning; surface property

DESCRIPTION (provided by applicant): The goal of this SBIR Phase I feasibility study is to create a novel instrument called a BioProfilometer (BioPro) for label free detection of biomolecular interactions. The instrument measures the surface profile of a planar chip designed to capture biological entities at specific domains. The BioPro does not incorporate force measurement or dynamic force feedback capability. Hence, it is not an atomic force microscope (AFM) and it will be faster, smaller, and less expensive than research-grade AFMs for the desired application. The BioPro does use a microfabricated device to rapidly read topographical events on a surface. The feasibility of this approach for molecular diagnostics will be tested using an affinity capture method called the ViriChip. The ViriChip captures viral particles to a surface, with each captured virus constituting an event that should be detectable by the BioPro. We anticipate that the novelty, simplicity and dedicated nature of this method and device will create value that can be translated into a commercially viable product.

描述（由申请人提供）：该 SBIR 第一阶段可行性研究的目标是创建一种称为 BioProfilometer (BioPro) 的新型仪器，用于无标记检测生物分子相互作用。该仪器测量平面芯片的表面轮廓，该平面芯片旨在捕获特定领域的生物实体。 BioPro 不具备力测量或动态力反馈功能。因此，它不是原子力显微镜 (AFM)，并且比所需应用的研究级 AFM 更快、更小且更便宜。 BioPro 确实使用微型设备来快速读取表面上的地形事件。这种分子诊断方法的可行性将使用称为 ViriChip 的亲和捕获方法进行测试。 ViriChip 将病毒颗粒捕获到表面，每个捕获的病毒都构成 BioPro 可以检测到的事件。我们预计，这种方法和设备的新颖性、简单性和专用性将创造价值，并转化为商业上可行的产品。