Biomolecular Profilometer

生物分子轮廓仪

• 批准号: 6831957
• 负责人: CURTIS L MOSHER
• 金额: $ 20万
• 依托单位: BIOFORCE NANOSCIENCES, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6831957
• 关键词: bioassay; bioengineering /biomedical engineering; biomedical equipment development; biosensor device; computer program /software; imaging /visualization /scanning; surface property

DESCRIPTION (provided by applicant): The goal of this SBIR Phase I feasibility study is to create a novel instrument called a BioProfilometer (BioPro) for label free detection of biomolecular interactions. The instrument measures the surface profile of a planar chip designed to capture biological entities at specific domains. The BioPro does not incorporate force measurement or dynamic force feedback capability. Hence, it is not an atomic force microscope (AFM) and it will be faster, smaller, and less expensive than research-grade AFMs for the desired application. The BioPro does use a microfabricated device to rapidly read topographical events on a surface. The feasibility of this approach for molecular diagnostics will be tested using an affinity capture method called the ViriChip. The ViriChip captures viral particles to a surface, with each captured virus constituting an event that should be detectable by the BioPro. We anticipate that the novelty, simplicity and dedicated nature of this method and device will create value that can be translated into a commercially viable product.

描述（由申请人提供）：此SBIR I期可行性研究的目的是创建一种名为“生物易生仪（Biopro”）的新颖仪器，用于对生物分子相互作用的无标记检测。该仪器测量旨在捕获特定领域的生物实体的平面芯片的表面剖面。 Biopro不包含力测量或动态力反馈能力。因此，它不是原子力显微镜（AFM），它将比研究级AFMS更快，更小，更便宜。 Biopro确实使用微生物装置来快速读取表面上的地形事件。这种方法对分子诊断的可行性将使用称为Virichip的亲和力捕获方法进行测试。 Virichip将病毒颗粒捕获到表面，每个捕获的病毒构成应由Biopro检测到的事件。我们预计，这种方法和设备的新颖性，简单性和敬业的性质将创造可转化为商业上可行的产品的价值。