A Wide-band Reflectance - DPOAE (WR-DP)Screener

宽带反射率 - DPOAE (WR-DP)Screener

• 批准号: 6736192
• 负责人: PATRICIA S JENG
• 金额: $ 20.09万
• 依托单位: MIMOSA ACOUSTICS
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-03-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6736192
• 关键词: audiometry; biomedical equipment development; child (0-11); clinical research; conductive hearing loss; ear disorder diagnosis; hearing disorders; hearing tests; human subject; interview; labyrinth; otoacoustic emission; questionnaires; sensorimotor system; sensorineural hearing loss

DESCRIPTION (provided by applicant): The goal of newborn hearing screening is to identify infants with sensorineural hearing loss (SNHL), but most neonates who fail screening have conductive hearing loss (CHL) rather than sensorineural hearing loss, resulting in high false positive rate and costly follow-up diagnostic evaluation. The Rhode Island study (1993) has shown that the prevalence of CHL over SNHL to be 17 vs. 3-6 per 1000. While in NICU the prevalence of CHL over SNHL raises to 36 vs. 23 per 1000. The ramifications of SNHL and CHL are different, so an accurate typing of the loss at the time of a newborn hearing screening is essential. This main objective of this proposal is to build a hearing screening device that combines wideband reflectance measurement system (RMS) with DPOAE measurement system into one system, where the former provides diagnostic evaluation for conductive hearing loss and the later provides diagnostic evaluation for the SNHL. So in one test, both conductive path and cochlear status are evaluated. Since both the reflectance measurement and the DPOAE measurement share an identical measurement, the extra time needed to perform hearing screening using the combined screening device will be no more than few minutes. The benefit of the expected outcome is reduced false positive rate, reduce follow up diagnostic cost, and reduced parental concern. The specific aims of Phase I is (1) to demonstrate the feasibility of distinguishing between conductive disorders (CD) and the inner ear pathologies (IEP) by combining the use of distortion product otoacoustic emission (DPOAE) and wide-band power reflectance measurements (WB-PR) in a single instrument used for hearing screening prototype instrument. (2) To develop a prototype instrument that will demonstrate the feasibility of using WB-PR to address the standing wave problem.

描述（由申请人提供）：新生儿听力筛查的目的是识别感音神经性听力损失（SNHL）的婴儿，但大多数未筛查的新生儿为传导性听力损失（CHL），而不是感音神经性听力损失，导致假阳性率高，后续诊断评估费用高。罗德岛研究（1993）表明，CHL在SNHL中的患病率为17比3 / 1000。而在新生儿重症监护室，CHL的患病率上升到36比23 / 1000。SNHL和CHL的后果是不同的，因此在新生儿听力筛查时准确分型损失是至关重要的。本提案的主要目标是构建一种将宽带反射测量系统（RMS）与DPOAE测量系统结合为一体的听力筛查设备，前者对传导性听力损失进行诊断评估，后者对SNHL进行诊断评估。因此，在一次测试中，评估了传导路径和耳蜗状态。由于反射率测量和DPOAE测量共享相同的测量值，因此使用组合筛选装置进行听力筛查所需的额外时间将不超过几分钟。预期结果的好处是减少假阳性率，减少随访诊断费用，并减少家长的担忧。