THE TREATMENT OF EATING DISORDERS

我建议设立一个独立科学家奖(K02)，以支持我在饮食失调的治疗和结果领域的研究计划。自1992年结束住院治疗以来，这一直是我工作的重点，自1995年以来，我一直是一个积极和富有成效的研究小组的首席调查员，该小组侧重于饮食失调、治疗和结果问题。申请中心围绕R01授予“针对神经性暴食症的分级护理与最佳可用护理”(R01-MH-59304)。这是一项为期五年的研究(现已进入第三个年头)，研究使用不同序列的自助、药物疗法和认知行为疗法来治疗神经性暴食症。除了测量这些不同治疗方法的疗效外 此外，还将衡量套餐的成本效益。明尼苏达大学精神病学系对这一奖项做出了强有力的机构承诺。该部门为研究活动提供强有力的行政支持和高度支持的环境，最近完成了4000平方英尺的精神病学动态研究中心(ARC)的建设，该中心容纳了我正在进行的研究活动。如果得到资助，这个奖项将把我从大量的临床工作中解放出来，并充分保护我75%的时间用于研究活动。这 增加的时间将使我能够通过明尼苏达大学临床结果研究中心进行成本效益分析方面的高级专业培训，通过明尼苏达大学临床结果研究中心进行复杂的临床结果研究技术方面的具体培训，与B.Timothy Walsh医学博士就ED治疗研究问题进行积极咨询，并与Christopher Fairburm医学博士就进食障碍病程和结果研究问题进行积极咨询。这些职业发展活动将使我能够利用明尼苏达州独特的研究人群和数据来追求我的研究目标，即研究有效且成本效益高的饮食障碍治疗方法，并检查其过程和成本。在该奖项期间和随后的几年中，计划进行大量研究，以利用这些新技能和独特的资源。

This proposal for an independent Scientist Award (K02) to support my research program in the area of the treatment and outcome of eating disorders. This has been the focus of my work since finishing residency in 1992 and since 1995 I have been the principal investigator of an active and productive research group focused on eating disorders treatment and outcome issues. The application centers around R01 grant "Stepped Care vs. Best Available care for Bulimia Nervosa" (R01-MH-59304). This is a five year study (now in its third year) examining the use of different sequences of self-help, pharmacotherapy, and cognitive behavioral therapy to treat bulimia nervosa. In addition to measuring the efficacy of these various treatment packages, cost efficacy will also be measured. The Department of Psychiatry at the University of Minnesota has made a strong institutional commitment to this award. The department provides strong administrative support and a highly supportive environment for research activities, and recently completed construction of a 4000 square feet Psychiatry Ambulatory Research Center (ARC) that houses my ongoing research activities. If funded, this award will free me up from substantial clinical duties and protect fully 75% of my time for research activities. This increased time will allow for advanced specialized training in cost efficacy analysis, specific training in sophisticated clinical outcomes research techniques through the Clinical Outcomes Research Center at the University of Minnesota, active consultation regarding ED treatment study issues with B. Timothy Walsh, M.D and active consultation on eating disorder course and outcome study issues with Christopher Fairbum, M.D. These career development activities will enable me to utilize the unique research populations and data available at Minnesota to pursue my research goals in the areas of studying effective and cost effective treatment for eating disorders and examining their course and their costs. Numerous studies are planned during this award and in the years that follow to leverage these new skills and unique resources.