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中文摘要
翻译
本项目的目标是研究 LT-IIa和LT-IIb。这两种毒素都是有效的粘膜佐剂, 免疫反应模式与霍乱毒素引起的免疫反应模式不同。的 毒素将被用作分子工具来研究 调节佐剂活性。我们将设计一种新的重组毒素 作为潜在的粘膜疫苗进行评估。
英文摘要
The goals of this project are to study the immunomodulatory activities of LT-IIa and LT-IIb. Both toxins are potent mucosal adjuvants which elicit patterns of immune responses distinct from those elicited by cholera toxin. The toxins will be used as molecular tools to investigate the mechanisms that regulate adjuvant activity. We will engineer a new class of recombinant toxins to evaluate as potential mucosal vaccines.
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会议论文
Specific induction of lethal autophagy in triple-negative breast cancer cells
Safe mucosal vaccines
Type II enterotoxins as mucosal immunomodulators
Mechanisms of Adjuvant Stimulation
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