Mechanisms of Adjuvant Stimulation
Mechanisms of Adjuvant Stimulation
批准号:
6719064
负责人:
Terry D. Connell
金额:
$10.46万
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-05-01 至 2007-01-31
关键词:
Escherichia coliantigen receptorsbacterial proteinscell population studychemical structure functionchimeric proteinsconfocal scanning microscopydrug delivery systemsenterotoxinsflow cytometrygangliosidesimmunocytochemistryimmunogeneticsimmunologic substance development /preparationimmunomodulatorsimmunoregulationimmunotherapyintermolecular interactionlaboratory mouseleukocyte activation /transformationlymphocytemucosal immunitynonhuman therapy evaluationpharmacokineticsreceptor couplingvaccine development
中文摘要
本项目的目标是研究
LT-IIa和LT-IIb。这两种毒素都是有效的粘膜佐剂,
免疫反应模式与霍乱毒素引起的免疫反应模式不同。的
毒素将被用作分子工具来研究
调节佐剂活性。我们将设计一种新的重组毒素
作为潜在的粘膜疫苗进行评估。
英文摘要
The goals of this project are to study the immunomodulatory activities of
LT-IIa and LT-IIb. Both toxins are potent mucosal adjuvants which elicit
patterns of immune responses distinct from those elicited by cholera toxin. The
toxins will be used as molecular tools to investigate the mechanisms that
regulate adjuvant activity. We will engineer a new class of recombinant toxins
to evaluate as potential mucosal vaccines.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Specific induction of lethal autophagy in triple-negative breast cancer cells
-
批准号:9324102
-
项目类别:
-
资助金额:$17.35万
-
财政年份:2017
-
负责人:Terry D. Connell
-
依托单位:
Safe mucosal vaccines
-
批准号:9112987
-
项目类别:
-
资助金额:$23.93万
-
财政年份:2015
-
负责人:Terry D. Connell
-
依托单位:
Type II enterotoxins as mucosal immunomodulators
-
批准号:7932550
-
项目类别:
-
资助金额:$29.2万
-
财政年份:2009
-
负责人:Terry D. Connell
-
依托单位:
Mechanisms of Adjuvant Stimulation
-
批准号:7007332
-
项目类别:
-
资助金额:$10.57万
-
财政年份:2002
-
负责人:Terry D. Connell
-
依托单位:
Mechanisms of Adjuvant Stimulation
-
批准号:6418543
-
项目类别:
-
资助金额:$10.54万
-
财政年份:2002
-
负责人:Terry D. Connell
-
依托单位:
Mechanisms of Adjuvant Stimulation
-
批准号:6839408
-
项目类别:
-
资助金额:$10.52万
-
财政年份:2002
-
负责人:Terry D. Connell
-
依托单位:
Mechanisms of Adjuvant Stimulation
-
批准号:6620525
-
项目类别:
-
资助金额:$10.51万
-
财政年份:2002
-
负责人:Terry D. Connell
-
依托单位:
TYPE II Enterotoxins as Mucosal Immunomodulators
-
批准号:6587277
-
项目类别:
-
资助金额:$0.4万
-
财政年份:2001
-
负责人:Terry D. Connell
-
依托单位:
TYPE II Enterotoxins as Mucosal Immunomodulators
-
批准号:6516627
-
项目类别:
-
资助金额:$30.06万
-
财政年份:2001
-
负责人:Terry D. Connell
-
依托单位:
TYPE II Enterotoxins as Mucosal Immunomodulators
-
批准号:6327096
-
项目类别:
-
资助金额:$30.35万
-
财政年份:2001
-
负责人:Terry D. Connell
-
依托单位:
Type II enterotoxins as mucosal immunomodulators
-
批准号:7623598
-
项目类别:
-
资助金额:$34.27万
-
财政年份:2001
-
负责人:Terry D. Connell
-
依托单位:
TYPE II Enterotoxins as Mucosal Immunomodulators
-
批准号:6719607
-
项目类别:
-
资助金额:$29.85万
-
财政年份:2001
-
负责人:Terry D. Connell
-
依托单位:
TYPE II Enterotoxins as Mucosal Immunomodulators
-
批准号:6551476
-
项目类别:
-
资助金额:$1.2万
-
财政年份:2001
-
负责人:Terry D. Connell
-
依托单位:
Type II enterotoxins as mucosal immunomodulators
-
批准号:7419022
-
项目类别:
-
资助金额:$34.27万
-
财政年份:2001
-
负责人:Terry D. Connell
-
依托单位:
TYPE II Enterotoxins as Mucosal Immunomodulators
-
批准号:6634693
-
项目类别:
-
资助金额:$29.82万
-
财政年份:2001
-
负责人:Terry D. Connell
-
依托单位:
Type II enterotoxins as mucosal immunomodulators
-
批准号:7845035
-
项目类别:
-
资助金额:$33.93万
-
财政年份:2001
-
负责人:Terry D. Connell
-
依托单位:
Type II enterotoxins as mucosal immunomodulators
-
批准号:8324366
-
项目类别:
-
资助金额:$31.7万
-
财政年份:2000
-
负责人:Terry D. Connell
-
依托单位:
Type II enterotoxins as mucosal immunomodulators
-
批准号:7089223
-
项目类别:
-
资助金额:$35.69万
-
财政年份:2000
-
负责人:Terry D. Connell
-
依托单位:
EXTRACELLULAR SECRETION IN VIBRIO CHOLERAE
-
批准号:6169262
-
项目类别:
-
资助金额:$11.85万
-
财政年份:1996
-
负责人:Terry D. Connell
-
依托单位:
EXTRACELLULAR SECRETION IN VIBRIO CHOLERAE
-
批准号:2442644
-
项目类别:
-
资助金额:$10.45万
-
财政年份:1996
-
负责人:Terry D. Connell
-
依托单位:
海外基金