Mechanisms of Adjuvant Stimulation
Mechanisms of Adjuvant Stimulation
批准号:
6839408
负责人:
Terry D. Connell
金额:
$10.52万
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-05-01 至 2007-01-31
关键词:
Escherichia coliantigen receptorsbacterial proteinscell population studychemical structure functionchimeric proteinsconfocal scanning microscopydrug delivery systemsenterotoxinsflow cytometrygangliosidesimmunocytochemistryimmunogeneticsimmunologic substance development /preparationimmunomodulatorsimmunoregulationimmunotherapyintermolecular interactionlaboratory mouseleukocyte activation /transformationlymphocytemucosal immunitynonhuman therapy evaluationpharmacokineticsreceptor couplingvaccine development
中文摘要
本项目的目的是研究的免疫调节活性
英文摘要
The goals of this project are to study the immunomodulatory activities of
LT-IIa and LT-IIb. Both toxins are potent mucosal adjuvants which elicit
patterns of immune responses distinct from those elicited by cholera toxin. The
toxins will be used as molecular tools to investigate the mechanisms that
regulate adjuvant activity. We will engineer a new class of recombinant toxins
to evaluate as potential mucosal vaccines.
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科研奖励(0)
会议论文
Specific induction of lethal autophagy in triple-negative breast cancer cells
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批准号:9324102
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项目类别:
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资助金额:$17.35万
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财政年份:2017
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负责人:Terry D. Connell
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依托单位:
Safe mucosal vaccines
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批准号:9112987
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项目类别:
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资助金额:$23.93万
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财政年份:2015
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负责人:Terry D. Connell
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依托单位:
Type II enterotoxins as mucosal immunomodulators
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批准号:7932550
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项目类别:
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资助金额:$29.2万
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财政年份:2009
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负责人:Terry D. Connell
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依托单位:
Mechanisms of Adjuvant Stimulation
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批准号:7007332
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项目类别:
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资助金额:$10.57万
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财政年份:2002
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负责人:Terry D. Connell
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依托单位:
Mechanisms of Adjuvant Stimulation
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批准号:6719064
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项目类别:
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资助金额:$10.46万
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财政年份:2002
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负责人:Terry D. Connell
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依托单位:
Mechanisms of Adjuvant Stimulation
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批准号:6418543
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项目类别:
-
资助金额:$10.54万
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财政年份:2002
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负责人:Terry D. Connell
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依托单位:
Mechanisms of Adjuvant Stimulation
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批准号:6620525
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项目类别:
-
资助金额:$10.51万
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财政年份:2002
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负责人:Terry D. Connell
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依托单位:
TYPE II Enterotoxins as Mucosal Immunomodulators
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批准号:6587277
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项目类别:
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资助金额:$0.4万
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财政年份:2001
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负责人:Terry D. Connell
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依托单位:
TYPE II Enterotoxins as Mucosal Immunomodulators
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批准号:6516627
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项目类别:
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资助金额:$30.06万
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财政年份:2001
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负责人:Terry D. Connell
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依托单位:
TYPE II Enterotoxins as Mucosal Immunomodulators
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批准号:6327096
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项目类别:
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资助金额:$30.35万
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财政年份:2001
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负责人:Terry D. Connell
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依托单位:
Type II enterotoxins as mucosal immunomodulators
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批准号:7623598
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项目类别:
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资助金额:$34.27万
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财政年份:2001
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负责人:Terry D. Connell
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依托单位:
TYPE II Enterotoxins as Mucosal Immunomodulators
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批准号:6719607
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项目类别:
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资助金额:$29.85万
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财政年份:2001
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负责人:Terry D. Connell
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依托单位:
TYPE II Enterotoxins as Mucosal Immunomodulators
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批准号:6551476
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项目类别:
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资助金额:$1.2万
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财政年份:2001
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负责人:Terry D. Connell
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依托单位:
TYPE II Enterotoxins as Mucosal Immunomodulators
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批准号:6634693
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项目类别:
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资助金额:$29.82万
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财政年份:2001
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负责人:Terry D. Connell
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依托单位:
Type II enterotoxins as mucosal immunomodulators
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批准号:7419022
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项目类别:
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资助金额:$34.27万
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财政年份:2001
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负责人:Terry D. Connell
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依托单位:
Type II enterotoxins as mucosal immunomodulators
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批准号:7845035
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项目类别:
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资助金额:$33.93万
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财政年份:2001
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负责人:Terry D. Connell
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依托单位:
Type II enterotoxins as mucosal immunomodulators
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批准号:8324366
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项目类别:
-
资助金额:$31.7万
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财政年份:2000
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负责人:Terry D. Connell
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依托单位:
Type II enterotoxins as mucosal immunomodulators
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批准号:7089223
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项目类别:
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资助金额:$35.69万
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财政年份:2000
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负责人:Terry D. Connell
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依托单位:
EXTRACELLULAR SECRETION IN VIBRIO CHOLERAE
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批准号:6169262
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项目类别:
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资助金额:$11.85万
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财政年份:1996
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负责人:Terry D. Connell
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依托单位:
EXTRACELLULAR SECRETION IN VIBRIO CHOLERAE
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批准号:2442644
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项目类别:
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资助金额:$10.45万
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财政年份:1996
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负责人:Terry D. Connell
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依托单位:
海外基金