Understanding the contribution of poor oral health to sarcopenia in older age and underlying mechanisms using UK and US cohort studies

使用英国和美国队列研究了解口腔健康状况不佳对老年肌少症的影响及其潜在机制

• 批准号: 9917763
• 负责人: Sheena Esther Ramsay
• 金额: $ 10.51万
• 依托单位: UNIVERSITY OF NEWCASTLE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9917763
• 关键词: Address; Age; Aging; Biological Markers; Body Composition; British; Chronic; Cohort Studies; Communities; Country; Cross-Sectional Studies; Data; Data Analyses; Dental; Dentures; Development; Diet; Dietary Factors; Dietary Intervention; Dietary Practices; Early identification; Elderly; Epidemiology; Goals; Health; Health Status; Heart; Hospitalization; Incidence; Inflammation; Inflammatory; Intervention; Investigation; Lead; Longitudinal Studies; Mastication; Measures; Mediating; Mediator of activation protein; Micronutrients; Muscular Atrophy; Nutritional Study; Older Population; Oral health; Outcome; Participant; Pathway interactions; Periodontal Diseases; Play; Population; Population Study; Population trends; Public Health; Research; Risk; Risk Factors; Role; Time; Tooth Loss; Xerostomia; adverse outcome; age related; age-related muscle loss; base; clinical care; cohort; cytokine; dietary supplements; disability; follow-up; frailty; improved; multidisciplinary; muscle form; novel; nutrition; population based; prevent; sarcopenia

PROJECT SUMMARY Population trends in aging present public health challenges in countries such as the USA and UK. Consequently, age-related health conditions such as sarcopenia (loss of muscle mass) are becoming increasingly prevalent. Oral health problems also increase dramatically with age, particularly tooth loss, periodontal disease, dry mouth, denture-related problems and chewing difficulties. Poor oral health has been implicated as a risk factor for sarcopenia. However, the extent to which and what particular oral health markers contribute to an increased risk of sarcopenia is not well-established. Moreover, the pathways or mechanisms by which oral health might influence sarcopenia are poorly understood. Current research is mostly from studies that are cross-sectional or have limited measures of sarcopenia and oral health in older populations. Such studies are not able to establish the contribution of oral health markers to the development of sarcopenia. To address these scientific evidence gaps, we aim to utilise data from two unique well-characterised cohort studies in the UK and USA. Our overarching goal is to investigate the contribution of oral health to the development of sarcopenia, and to understand the mechanisms underlying this relationship. Our research objectives are to: 1) determine the extent to which markers of poor oral health (periodontal disease, tooth loss, dry mouth, denture problems, chewing difficulties) are associated with incidence of sarcopenia over a 6-year follow-up; 2) determine the role of dietary factors as potential mechanisms underlying the association of poor oral health with incidence of sarcopenia; and 3) determine the role of inflammation as mediators of the association of poor oral health with incidence of sarcopenia. These will be achieved through secondary data analyses of two large population-based longitudinal studies of older people in the UK and USA, which are uniquely-placed for these investigations. These studies have detailed data on oral health, dietary factors, inflammation, as well as sarcopenia over time. The British Regional Heart Study is the only such longitudinal study of older people in the UK. The study comprises participants from 24 towns across Britain, followed-up at age 71-92 years in 2012 and at 77- 98 years. The US Health, Aging and Body Composition Study offers complementary data in a population-based study of older people from Memphis and Pittsburgh followed-up from age 71-80 years. These investigations based, on novel conceptual hypotheses and cross-country comparisons in UK and US studies, will significantly advance our understanding of the role that oral health plays in an important geriatric condition such as sarcopenia. The goal of this research is to provide the scientific basis for better identification and management of oral health conditions in older people, and to identify targets for interventions to reduce sarcopenia. These efforts are ultimately aimed at better health of older people.

项目概要 人口老龄化趋势给美国和英国等国家带来了公共卫生挑战。 因此，与年龄相关的健康状况，例如肌肉减少症（肌肉质量损失）正在成为 越来越普遍。口腔健康问题也会随着年龄的增长而急剧增加，特别是牙齿脱落， 牙周病、口干、假牙相关问题和咀嚼困难。口腔健康状况不佳 被认为是肌肉减少症的危险因素。然而，口头表达的程度和具体内容 导致肌肉减少症风险增加的健康指标尚不明确。此外， 人们对口腔健康可能影响肌肉减少症的途径或机制知之甚少。 目前的研究主要来自横断面研究或对肌肉减少症的测量有限 和老年人口的口腔健康。此类研究无法确定口腔健康的贡献 肌肉减少症发展的标志物。 为了解决这些科学证据差距，我们的目标是利用来自两个独特的、充分表征的数据 英国和美国的队列研究。我们的首要目标是调查口腔健康的贡献 肌肉减少症的发展，并了解这种关系背后的机制。 我们的研究目标是： 1) 确定口腔健康状况不佳的标志物（牙周病）的程度 疾病、牙齿脱落、口干、假牙问题、咀嚼困难）与以下疾病的发生有关： 6 年随访期间出现肌肉减少症； 2）确定饮食因素作为潜在机制的作用 口腔健康状况不佳与肌肉减少症发病率之间存在关联； 3）确定角色 炎症是口腔健康状况不佳与肌少症发病率相关的介质。 这些将通过对两个基于人口的大型纵向数据分析来实现 对英国和美国老年人的研究，这些研究在这些调查中具有独特的地位。这些 研究提供了有关口腔健康、饮食因素、炎症以及肌肉减少症随时间变化的详细数据。 英国区域心脏研究是英国唯一针对老年人的此类纵向研究。研究 包括来自英国 24 个城镇的参与者，2012 年对 71-92 岁以及 77-92 岁的参与者进行了随访 98年。美国健康、衰老和身体成分研究提供了补充数据 对孟菲斯和匹兹堡 71-80 岁老年人进行的基于人群的跟踪研究。 这些调查基于新颖的概念假设和英国和英国的跨国比较 美国的研究将显着增进我们对口腔健康在重要疾病中所扮演的角色的理解 老年病，如肌肉减少症。本研究的目的是提供科学依据 更好地识别和管理老年人的口腔健康状况，并确定目标 减少肌肉减少症的干预措施。这些努力的最终目的是为了改善老年人的健康。

项目成果

Neighborhood Deprivation and Changes in Oral Health in Older Age: A Longitudinal Population-Based Study.

社区剥夺和老年人口腔健康的变化：一项基于人口的纵向研究。

• DOI: 10.1177/00220345231224337
• 发表时间: 2024
• 期刊: Journal of dental research
• 影响因子: 7.6
• 作者: Ganbavale,SG;Papachristou,E;Mathers,JC;Papacosta,AO;Lennon,LT;Whincup,PH;Wannamethee,SG;Ramsay,SE
• 通讯作者: Ramsay,SE

Associations of poor oral health with frailty and physical functioning in the oldest old: results from two studies in England and Japan.

• DOI: 10.1186/s12877-021-02081-5
• 发表时间: 2021-03-18
• 期刊: BMC geriatrics
• 影响因子: 4.1
• 作者: Albani V;Nishio K;Ito T;Kotronia E;Moynihan P;Robinson L;Hanratty B;Kingston A;Abe Y;Takayama M;Iinuma T;Arai Y;Ramsay SE
• 通讯作者: Ramsay SE

Cohort Profile Update: The British Regional Heart Study 1978-2018: 40 years of follow-up of older British men.

• DOI: 10.1093/ije/dyac122
• 发表时间: 2023-06-06
• 期刊: International journal of epidemiology
• 影响因子: 7.7