DEVELOPMENT/TESTING OF ARTIFICIAL RETINAS FOR THE BLIND

盲人人造视网膜的开发/测试

• 批准号: 6754483
• 负责人: Robert Jay Greenberg
• 金额: $ 237.3万
• 依托单位: SECOND SIGHT MEDICAL PRODUCTS, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2006-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6754483
• 关键词: bioengineering /biomedical engineering; biomaterial development /preparation; dogs; electronic stimulator; eye prosthesis; medical implant science; retina; retina degeneration

DESCRIPTION (Adapted from applicant's abstract): Our proposed research for this partnership grant is to develop a long-term implantable retinal stimulator for patients blinded by outer retinal degenerations. Using technologies developed by the Alfred E. Mann group of companies over the past 30 years for implantable stimulators, we will develop a chronic retinal stimulator and associated external hardware for use both in research and as a clinical device. In order to achieve this goal, several areas of research are still needed. In this bioengineering research partnership, academia will collaborate with industry to accomplish the basic research necessary to make a chronic retinal prosthesis a reality. Areas of basic research that we will focus on include: electrode geometry and electrode material selection, surgical attachment of the retinal implant, low power electronic circuit design, and hermetic packaging. Each of these areas needs additional research for the creation of an optimal chronic retinal prosthesis which will enable persons blinded by outer retinal degeneration to regain the most important loss they have suffered--the loss of mobility. The aim of this five-year proposal is to complete the design and manufacture of a retinal prosthesis and associated external hardware and tests it chronically in animals, so that an investigational device application can be made to the FDA in preparation for a clinical trial.

描述（改编自申请人的摘要）：我们建议的研究 合作伙伴赠款是为了开发长期植入视网膜刺激剂 因视网膜外变性而蒙蔽的患者。使用开发的技术 在过去的30年中，Alfred E. Mann集团的植入 刺激器，我们将开发一个慢性视网膜刺激器和相关的 外部硬件用于研究和临床设备。为了 为了实现这一目标，仍然需要几个研究领域。在这个 生物工程研究合作伙伴关系，学术界将与行业合作 完成进行慢性视网膜假体所必需的基础研究 现实。我们将重点关注的基础研究领域包括：电极 几何和电极材料选择，视网膜的手术附着 植入物，低功率电子电路设计和密封包装。每个 这些领域需要额外的研究才能创建最佳的慢性 视网膜假体将使人们能够被视网膜视而不见 堕落以恢复他们遭受的最重要的损失 - 损失 机动性。这个五年建议的目的是完成设计和 制造视网膜假体以及相关的外部硬件和测试 它在动物中长期存在，因此可以使用研究设备的应用 向FDA做准备进行临床试验。