DEVELOPMENT/TESTING OF ARTIFICIAL RETINAS FOR THE BLIND

盲人人造视网膜的开发/测试

• 批准号: 7124476
• 负责人: Robert Jay Greenberg
• 金额: $ 40.69万
• 依托单位: SECOND SIGHT MEDICAL PRODUCTS, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2006-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7124476
• 关键词: bioengineering /biomedical engineering; biomaterial development /preparation; dogs; electronic stimulator; eye prosthesis; medical implant science; retina; retina degeneration

DESCRIPTION (Adapted from applicant's abstract): Our proposed research for this partnership grant is to develop a long-term implantable retinal stimulator for patients blinded by outer retinal degenerations. Using technologies developed by the Alfred E. Mann group of companies over the past 30 years for implantable stimulators, we will develop a chronic retinal stimulator and associated external hardware for use both in research and as a clinical device. In order to achieve this goal, several areas of research are still needed. In this bioengineering research partnership, academia will collaborate with industry to accomplish the basic research necessary to make a chronic retinal prosthesis a reality. Areas of basic research that we will focus on include: electrode geometry and electrode material selection, surgical attachment of the retinal implant, low power electronic circuit design, and hermetic packaging. Each of these areas needs additional research for the creation of an optimal chronic retinal prosthesis which will enable persons blinded by outer retinal degeneration to regain the most important loss they have suffered--the loss of mobility. The aim of this five-year proposal is to complete the design and manufacture of a retinal prosthesis and associated external hardware and tests it chronically in animals, so that an investigational device application can be made to the FDA in preparation for a clinical trial.

描述（改编自申请人摘要）：我们对此提出的研究建议

项目成果

The Detection of Motion by Blind Subjects With the Epiretinal 60-Electrode (Argus II) Retinal Prosthesis.

• DOI: 10.1001/2013.jamaophthalmol.221
• 发表时间: 2013-02
• 期刊: JAMA OPHTHALMOLOGY
• 影响因子: 8.1
• 作者: Dorn, Jessy D.;Ahuja, Ashish K.;Caspi, Avi;da Cruz, Lyndon;Dagnelie, Gislin;Sahel, Jose-Alain;Greenberg, Robert J.;McMahon, Matthew J.
• 通讯作者: McMahon, Matthew J.

Microsensors and microbiosensors for retinal implants.

用于视网膜植入物的微传感器和微生物传感器。

• DOI: 10.2741/1518
• 发表时间: 2005
• 期刊: Frontiers in bioscience : a journal and virtual library
• 作者: Zhou,DavidD;Greenberg,RobertJ
• 通讯作者: Greenberg,RobertJ

The value of preoperative tests in the selection of blind patients for a permanent microelectronic implant.

• 发表时间: 2003
• 期刊: Transactions of the American Ophthalmological Society
• 作者: D. Yanai;R. Lakhanpal;J. Weiland;M. Mahadevappa;G. V. Van Boemel;G. Fujii;R. Greenberg;Sean Caffey-Sean-Caf

Neural responses elicited by electrical stimulation of the retina.

视网膜电刺激引起的神经反应。

• 发表时间: 2006
• 期刊: Transactions of the American Ophthalmological Society
• 作者: Chen,Shih-Jen;Mahadevappa,Manjunatha;Roizenblatt,Roberto;Weiland,James;Humayun,Mark
• 通讯作者: Humayun,Mark