DEVELOPMENT/TESTING OF ARTIFICIAL RETINAS FOR THE BLIND

盲人人造视网膜的开发/测试

基本信息

项目摘要

DESCRIPTION (Adapted from applicant's abstract): Our proposed research for this partnership grant is to develop a long-term implantable retinal stimulator for patients blinded by outer retinal degenerations. Using technologies developed by the Alfred E. Mann group of companies over the past 30 years for implantable stimulators, we will develop a chronic retinal stimulator and associated external hardware for use both in research and as a clinical device. In order to achieve this goal, several areas of research are still needed. In this bioengineering research partnership, academia will collaborate with industry to accomplish the basic research necessary to make a chronic retinal prosthesis a reality. Areas of basic research that we will focus on include: electrode geometry and electrode material selection, surgical attachment of the retinal implant, low power electronic circuit design, and hermetic packaging. Each of these areas needs additional research for the creation of an optimal chronic retinal prosthesis which will enable persons blinded by outer retinal degeneration to regain the most important loss they have suffered--the loss of mobility. The aim of this five-year proposal is to complete the design and manufacture of a retinal prosthesis and associated external hardware and tests it chronically in animals, so that an investigational device application can be made to the FDA in preparation for a clinical trial.
描述(改编自申请人的摘要):我们为此提出的研究 合作伙伴赠款是开发一种长期植入式视网膜刺激器, 因外部视网膜变性而失明的患者。利用开发的技术 阿尔弗雷德·E曼恩集团公司在过去的30年里为植入式 刺激器,我们将开发一种慢性视网膜刺激器和相关的 用于研究和临床设备的外部硬件。为了 为实现这一目标,仍需在若干领域开展研究。在这 生物工程研究伙伴关系,学术界将与工业界合作, 完成必要的基础研究,使慢性视网膜假体, 现实我们将重点关注的基础研究领域包括:电极 几何形状和电极材料的选择,视网膜的手术附着 植入、低功率电子电路设计和密封封装。中的每 这些领域需要额外的研究,以创造一个最佳的慢性 使人因外部视网膜病变而失明的视网膜假体 退化,以恢复他们所遭受的最重要的损失-损失 迁移率这个五年计划的目标是完成设计, 视网膜假体和相关外部硬件的制造和测试 它在动物中长期存在,因此研究器械应用可以 为临床试验做准备

项目成果

期刊论文数量(13)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The Detection of Motion by Blind Subjects With the Epiretinal 60-Electrode (Argus II) Retinal Prosthesis.
  • DOI:
    10.1001/2013.jamaophthalmol.221
  • 发表时间:
    2013-02
  • 期刊:
  • 影响因子:
    8.1
  • 作者:
    Dorn, Jessy D.;Ahuja, Ashish K.;Caspi, Avi;da Cruz, Lyndon;Dagnelie, Gislin;Sahel, Jose-Alain;Greenberg, Robert J.;McMahon, Matthew J.
  • 通讯作者:
    McMahon, Matthew J.
Microsensors and microbiosensors for retinal implants.
用于视网膜植入物的微传感器和微生物传感器。
The value of preoperative tests in the selection of blind patients for a permanent microelectronic implant.
  • DOI:
  • 发表时间:
    2003
  • 期刊:
  • 影响因子:
    0
  • 作者:
    D. Yanai;R. Lakhanpal;J. Weiland;M. Mahadevappa;G. V. Van Boemel;G. Fujii;R. Greenberg;Sean Caffey-Sean-Caf
  • 通讯作者:
    D. Yanai;R. Lakhanpal;J. Weiland;M. Mahadevappa;G. V. Van Boemel;G. Fujii;R. Greenberg;Sean Caffey-Sean-Caf
Neural responses elicited by electrical stimulation of the retina.
视网膜电刺激引起的神经反应。
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Robert Jay Greenberg其他文献

Robert Jay Greenberg的其他文献

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{{ truncateString('Robert Jay Greenberg', 18)}}的其他基金

Development of an AMF Orion/Blackrock HD-USEA based 60/128 channel implantable wireless simulator system for human auditory nerve implants
开发基于 AMF Orion/Blackrock HD-USEA 的 60/128 通道植入式无线模拟器系统,用于人类听觉神经植入
  • 批准号:
    10454504
  • 财政年份:
    2020
  • 资助金额:
    $ 40.69万
  • 项目类别:
Development of an AMF Orion/Blackrock HD-USEA based 60/128 channel implantable wireless simulator system for human auditory nerve implants
开发基于 AMF Orion/Blackrock HD-USEA 的 60/128 通道植入式无线模拟器系统,用于人类听觉神经植入
  • 批准号:
    10011251
  • 财政年份:
    2020
  • 资助金额:
    $ 40.69万
  • 项目类别:
Development of an AMF Orion/Blackrock HD-USEA based 60/128 channel implantable wireless simulator system for human auditory nerve implants
开发基于 AMF Orion/Blackrock HD-USEA 的 60/128 通道植入式无线模拟器系统,用于人类听觉神经植入
  • 批准号:
    10470963
  • 财政年份:
    2020
  • 资助金额:
    $ 40.69万
  • 项目类别:
Early Feasibility Clinical Trial of a Visual Cortical Prosthesis
视觉皮质假体的早期可行性临床试验
  • 批准号:
    10665808
  • 财政年份:
    2018
  • 资助金额:
    $ 40.69万
  • 项目类别:
Early Feasibility Clinical Trial of a Visual Cortical Prosthesis
视觉皮质假体的早期可行性临床试验
  • 批准号:
    10404502
  • 财政年份:
    2018
  • 资助金额:
    $ 40.69万
  • 项目类别:
Development and Testing of Low Vision Assessment Tools for Retinal Prostheses.
视网膜假体低视力评估工具的开发和测试。
  • 批准号:
    7926853
  • 财政年份:
    2010
  • 资助金额:
    $ 40.69万
  • 项目类别:
Research/Development of Artificial Rentinas for the Blind
盲人人工视网膜的研究/开发
  • 批准号:
    7289698
  • 财政年份:
    2000
  • 资助金额:
    $ 40.69万
  • 项目类别:
DEVELOPMENT/TESTING OF ARTIFICIAL RETINAS FOR THE BLIND
盲人人造视网膜的开发/测试
  • 批准号:
    6518659
  • 财政年份:
    2000
  • 资助金额:
    $ 40.69万
  • 项目类别:
DEVELOPMENT/TESTING OF ARTIFICIAL RETINAS FOR THE BLIND
盲人人造视网膜的开发/测试
  • 批准号:
    6754483
  • 财政年份:
    2000
  • 资助金额:
    $ 40.69万
  • 项目类别:
DEVELOPMENT/TESTING OF ARTIFICIAL RETINAS FOR THE BLIND
盲人人造视网膜的开发/测试
  • 批准号:
    6071264
  • 财政年份:
    2000
  • 资助金额:
    $ 40.69万
  • 项目类别:
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