Research/Development of Artificial Rentinas for the Blind

盲人人工视网膜的研究/开发

基本信息

批准号：
7289698
负责人：
Robert Jay Greenberg
金额：
$ 267.17万
依托单位：
SECOND SIGHT MEDICAL PRODUCTS, INC.
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
起止时间：
2000-07-01 至 2011-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7289698
关键词：
Accommodation phosphene Algorithms Animal Model Animal Testing Animals Area Blinded Canis familiaris Chronic Clinic Clinical Clinical Research Code Collaborations Computer software Development Devices Effectiveness Electric Stimulation Electrodes Electrophysiology (science)Engineering Environment Eye Eye Movements Foundations Funding Goals Grant Head Head Movements Human Image Implant Institutes Institution Invasive Learning Localized Location Macular degeneration Measures Mechanics Modeling Movement Numbers Operative Surgical Procedures Patients Pattern Performance Phase Physicians Physiologic pulse Physiology Positioning Attribute Prosthesis Pulse taking Range Rattus Relative (related person)Research Research Personnel Resolution Retina Retinal Retinal Degeneration Retinitis Pigmentosa Safety Scientist Series Surface System Technology Testing Tissues Vision Work blind design human subject implantable device multidisciplinary next generation novel patch clamp programs prototype relating to nervous system research and development research clinical testing research study retinal prosthesis size tool visual process visual processing

项目摘要

DESCRIPTION (provided by applicant): The long term goal of this BRP remains the development of a clinically useful retinal prosthesis for patients blinded by outer retinal degenerations, such as retinitis pigmentosa and macular degeneration. In the first funding period, we not only completed all our aims, including the creation and long-term animal testing of a fully functional 16 electrode prototype system, but we also successfully implanted six subjects with this device, the world's only active long-term retinal prostheses, in a FDA-approved study. In the next phase of our research, we will: 1. Complete the development of a versatile epiretinal prosthesis (A-60), test its reliability and safety in animals, and implant it in humans. Through a unique pairing of electrophysiological recordings in animal models of retinal degeneration and clinical experiments in human subjects, we will use this device to: 2. Determine electrode array design specifications, compare epiretinal and subretinal configurations, determine electrical stimulation algorithms to maximize spatial resolution and brightness range, and determine the need for eye tracking in a next generation retinal prosthesis. Finally, we will 3. Design, test, and implant in humans a next generation retinal prosthesis to restore useful vision. To accomplish these challenging but attainable goals, this proposal brings together a sophisticated multidisciplinary team including a non-profit foundation (AMF, with 30+ years of implantable device expertise and specialized facilities), three academic institutions (USC for human clinical testing and patch-clamp physiology; Doheny Eye Institute for surgical and large animal studies; and The Salk Institute for multi- electrode physiology) and a private company (Second Sight for engineering research and development, manufacturing, and regulatory). Our continued collaboration with engineers, scientists and physicians will allow us to achieve our goal of providing many blind patients with an important therapy where none currently exists.

描述（由申请人提供）：该BRP的长期目标仍然是因视网膜外变性（例如色素性视网膜炎和黄斑变性）而蒙蔽的临床有用的视网膜假体的发展。在第一个融资期内，我们不仅完成了所有目标，包括对功能齐全的16电极原型系统的创建和长期动物测试，而且我们还成功地将六个受试者植入了该设备，这是世界上唯一的活跃的长期视网膜假体，在FDA认可的研究中。在我们的下一阶段，我们将：1。完成多功能前假体（A-60）的发展，测试其在动物中的可靠性和安全性，并将其植入人类。通过在人类受试者的视网膜变性和临床实验的动物模型中的电生理记录的独特配对，我们将使用此设备来：2。确定电极阵列设计规范，比较电网和下视网膜下构型，确定电刺激算法，以最大程度地提高到一代人的视力范围，以最大程度地提高范围。最后，我们将在人类中进行设计，测试和植入一个下一代视网膜假体以恢复有用的视力。为了实现这些具有挑战性但可实现的目标，该提案将一个复杂的多学科团队汇集在一起，包括非营利基金会（AMF，拥有30多年的可植入设备专业知识和专业设施），三个学术机构（USC人类临床测试和斑块钳理生理学的人类临床测试和多个私人研究所；用于工程研发，制造和监管）。我们与工程师，科学家和医生的持续合作将使我们能够实现我们的目标，即为许多盲人患者提供目前不存在的重要疗法。