OREGON NODE - NATIONAL CLINICAL TRIALS NETWORK

这项提案呼吁在俄勒冈州研究人员联盟、社区治疗计划和药物滥用治疗州政策小组的基础上，创建NIDA全国药物治疗临床试验网络的俄勒冈地区节点(OR-Node)。该联盟名为“俄勒冈州弥合实践和研究之间的差距：与基于社区的药物和酒精治疗(Lamb、Greenlick和McCarty)建立伙伴关系”。拟议的OR-Node是由三个研究和培训机构、30多名合作研究人员和俄勒冈州治疗提供者社区组成的伙伴关系。该研究小组带来了来自俄勒冈健康科学大学、凯撒永久健康研究中心和俄勒冈研究所的资源。来自这些机构的调查人员和运营人员将组成OR-Node的区域研究和培训中心(RRTC)。这些卓越中心中的每一个都为OR-Node提供高级研究人员，每个中心都为合作伙伴关系带来了一套特殊的其他资源，如方法和机构设置，并为俄勒冈州人口的所有部分提供治疗服务。OR-Node的结构实现了研究机构和治疗界之间的全面伙伴关系安排。在本提案中提出了三个研究概念，以展示OR-Node研究人员可以进行的全面研究以及OR-Node向国家网络提供的资源类型。研究的概念是：对开发和测试社区治疗计划中创新扩散模式的国家网络治疗计划进行定量和定性评估，作为药物滥用行为治疗辅助的抗抑郁药物的临床试验，以及加强有药物滥用或依赖问题的轻度或中度精神发育迟滞患者的招募和治疗的项目TOP。

This proposal calls for the creation of the Oregon Regional Node (OR- Node) of NIDA's national drug treatment clinical trials network on the basis of an Oregon consortium of the researchers, community treatment programs and the state policy group for substance abuse treatment. This consortium, "Oregon Bridging the Gap Between Practice and Research: Forging Partnerships with Community-Based Drug and Alcohol Treatment (Lamb, Greenlick, and McCarty). The proposed OR-Node is a partnership of three research and training organizations, more than 30 collaborating investigators, and the treatment provider community of the State of Oregon. The research group brings resources from the Oregon Health Sciences University, the Kaiser Permanente Center for Health Research, and the Oregon Research Institute. Investigators and operations personnel from these institutions will form the Regional Research and Training Center (RRTC) of OR-Node. Each of these centers of excellence provides senior research personnel to OR-NODE and each brings a special set of other resources to the partnership, such as the approaches and institutional settings, and provides treatment services to all segments of the Oregon population. The structure of the OR-Node operationalizes a full partnership arrangements among the research institutions and the treatment community. Three research concepts are offered in this proposal, selected to exhibit the full-range of research that can be carried out by the OR-Node researchers and the type of resources OR-Node offers to the national network. The research concepts are: a quantitative and qualitative assessment of the national network treatment programs developing and testing a model of diffusion of innovation among community-based treatment programs, a clinical trial of antidepressants as an adjuvant in behavioral treatment for drug abuse, and a project top enhance the recruitment and treatment of persons with mild or moderate mental retardation with drug abuse or dependency problems.