OREGON NODE - NATIONAL CLINICAL TRIALS NETWORK

该提案呼吁在俄勒冈州研究人员、社区治疗项目和药物滥用治疗州政策小组的基础上，建立NIDA国家药物治疗临床试验网络的俄勒冈地区节点（OR- Node）。这个联盟，“俄勒冈弥合实践与研究之间的差距：与社区药物和酒精治疗建立伙伴关系”（Lamb， Greenlick和McCarty）。拟议的OR-Node是由三个研究和培训机构、30多名合作调查人员以及俄勒冈州的治疗提供者社区组成的伙伴关系。该研究小组带来了来自俄勒冈健康科学大学、凯撒永久健康研究中心和俄勒冈研究所的资源。这些机构的调查人员和操作人员将组成OR-Node的区域研究和培训中心（RRTC）。这些卓越中心中的每一个都为OR-NODE提供高级研究人员，并为合作伙伴关系带来一套特殊的其他资源，例如方法和机构设置，并为俄勒冈州所有人群提供治疗服务。OR-Node的结构在研究机构和治疗界之间实现了全面的伙伴关系安排。本提案中提供了三个研究概念，选择这些概念是为了展示OR-Node研究人员可以进行的全方位研究以及OR-Node为国家网络提供的资源类型。研究的概念是：对国家网络治疗方案进行定量和定性评估，开发和测试创新在社区治疗方案之间的扩散模式，进行抗抑郁药作为药物滥用行为治疗辅助手段的临床试验，以及加强对有药物滥用或依赖问题的轻度或中度智力迟钝者的招募和治疗的项目。

This proposal calls for the creation of the Oregon Regional Node (OR- Node) of NIDA's national drug treatment clinical trials network on the basis of an Oregon consortium of the researchers, community treatment programs and the state policy group for substance abuse treatment. This consortium, "Oregon Bridging the Gap Between Practice and Research: Forging Partnerships with Community-Based Drug and Alcohol Treatment (Lamb, Greenlick, and McCarty). The proposed OR-Node is a partnership of three research and training organizations, more than 30 collaborating investigators, and the treatment provider community of the State of Oregon. The research group brings resources from the Oregon Health Sciences University, the Kaiser Permanente Center for Health Research, and the Oregon Research Institute. Investigators and operations personnel from these institutions will form the Regional Research and Training Center (RRTC) of OR-Node. Each of these centers of excellence provides senior research personnel to OR-NODE and each brings a special set of other resources to the partnership, such as the approaches and institutional settings, and provides treatment services to all segments of the Oregon population. The structure of the OR-Node operationalizes a full partnership arrangements among the research institutions and the treatment community. Three research concepts are offered in this proposal, selected to exhibit the full-range of research that can be carried out by the OR-Node researchers and the type of resources OR-Node offers to the national network. The research concepts are: a quantitative and qualitative assessment of the national network treatment programs developing and testing a model of diffusion of innovation among community-based treatment programs, a clinical trial of antidepressants as an adjuvant in behavioral treatment for drug abuse, and a project top enhance the recruitment and treatment of persons with mild or moderate mental retardation with drug abuse or dependency problems.