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The Role of Behavior Therapy Combined with Buprenorphine for the Treatment of Opioid Use Disorder

行为疗法联合丁丙诺啡治疗阿片类药物使用障碍的作用

基本信息

批准号：
10440820
负责人：
Rebecca Kathryn McHugh
金额：
$ 35.06万
依托单位：
MCLEAN HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-05-01 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10440820
关键词：
Address Age Area Behavior Therapy Buprenorphine Clinical Clinical Treatment Clinical Trials Cognitive Therapy Common Data Element Counseling Data Data Analyses Data Set Decision Making Drops Drug Screening Employment Engineering Epidemic Family Funding Future Heterogeneity Impairment Individual Knowledge Legal Maintenance Measures Medicine Mental disorders Methodology Methods National Institute of Drug Abuse Opioid Opioid Analgesics Outcome Participant Patient Self-Report Patients Persons Pharmaceutical Preparations Public Health Randomized Clinical Trials Relapse Reporting Research Review Literature Role Sample Size Sampling Structure Subgroup Substance Use Disorder Testing United States United States National Academy of Sciences Update Urine Work base buprenorphine treatment chronic pain clinical care cocaine use data harmonization effective therapy efficacy testing functional disability functional outcomes heroin use improved innovation interest non-opioid analgesic novel opioid epidemic opioid misuse opioid overdose opioid use opioid use disorder overdose death patient subsets personalized approach personalized medicine predicting response primary outcome randomized trial response secondary analysis substance use systematic review treatment effect treatment response

项目摘要

Project Summary/Abstract The misuse of opioids has reached an epidemic level in the United States, with approximately 2 million people suffering from opioid use disorder and over 46,800 opioid overdose fatalities in 2019. Medication-based treatment for opioid use disorder—such as buprenorphine maintenance—is effective and can save lives, however, approximately half of people who receive buprenorphine do not adequately respond or drop out of treatment. In contrast to other substance use disorders, the addition of behavior therapy to buprenorphine has not consistently shown improvements in opioid use outcomes for opioid use disorder. Preliminary evidence suggests that not everyone may need the addition of behavior therapy to buprenorphine to reduce opioid use, but that certain subgroups of people may benefit from behavior therapy. The ability to understand heterogeneity in response to treatment for opioid use disorder is hampered by the need for very large sample sizes to test questions about moderators of treatment response. Understanding subgroup differences can ultimately inform personalized medicine approaches to the treatment of opioid use disorder. Our objective for this proposal is to answer urgent questions about subgroup responses to behavioral therapy by harmonizing data from 4 completed clinical trials of treatment for opioid use disorder. These NIDA-funded randomized trials each tested the efficacy of behavior therapy added to buprenorphine maintenance for opioid use disorder and include common data elements, allowing for their harmonization. Our project aims include: (1) to identify subgroups who respond to behavior therapy when added to buprenorphine maintenance for opioid use disorder, (2) to quantify the efficacy of behavior therapy for improving buprenorphine treatment retention, and (3) to quantify the efficacy of behavior therapy for functional outcomes. The results from this study will provide important information about who responds to behavior therapy and the effect of behavior therapy on non-opioid use endpoints. Our proposal will utilize well-validated longitudinal data analysis methods, including a rigorous approach to missing data. By using existing datasets, this proposal provides an efficient way to answer urgent questions about the treatment of opioid use disorder and provides significant added value to these trials. These findings can be immediately used to inform personalized approaches to treatment for opioid use disorder and will also contribute to understanding of the impact of behavior therapy on endpoints of interest to patients and families.

项目总结/文摘