Bases of Normal and Disordered Reading

正常阅读和无序阅读的基础

• 批准号: 7039107
• 负责人: FRANK R MANIS
• 金额: $ 38.52万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-02-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7039107
• 关键词: behavior test; behavioral /social science research tag; brain imaging /visualization /scanning; child behavior; clinical research; cognition; computational neuroscience; dyslexia; functional magnetic resonance imaging; human subject; language disorders; longitudinal human study; middle childhood (6-11); neural information processing; neuropsychological tests; phonology; psychomotor reaction time; reading disorder; speech disorders; speech recognition; visual perception

DESCRIPTION (provided by applicant): This proposal is a competing continuation of a previous grant, "Perceptual, linguistic, and computational bases of dyslexia." The focus of our research was on using a connectionist model of reading to frame empirical studies of reading acquisition and dyslexia, with an emphasis on identifying subtypes associated with different underlying impairments. During the previous granting period, we conducted a longitudinal study of reading acquisition and dyslexia and behavioral experiments concerning speech perception, spelling, and learning targeted at identifying possible causes of dyslexia. We also completed a major extension of the Seidenberg and McClelland (1980) model to developmental dyslexia and implemented a model of the computation of word meaning from print. The behavioral research suggests that there are phonological and non-phonological bases for dyslexia which produce different behavioral profiles that are stable over time. Overt speech recognition deficits were only observed in a subset of phonological dyslexics with broader language impairments. Thus the studies suggest that phonological impairments can be severe enough to impact reading negatively but leave speech perception unaffected. In the next granting period we propose to conduct new experiments focused on the nature of the impairments in phonology, speech and visual perception that have been observed in dyslexics, the effects of these impairments on reading behavior, and whether different brain activation patterns underlie different subtypes. The research program involves using behavioral experimentation, computational modeling, and neuroimaging techniques to develop a unified account of normal and disordered reading. The studies are likely to yield advances with regard to theories of reading, the bases of reading impairments, basic aspects of normal and disordered speech and visual perception, and the brain bases of reading ability and disability.

描述（由申请人提供）：本提案为竞争性延续

项目成果

Phonological processing is uniquely associated with neuro-metabolic concentration.

• DOI: 10.1016/j.neuroimage.2012.10.092
• 发表时间: 2013-02-15
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Bruno JL;Lu ZL;Manis FR
• 通讯作者: Manis FR

Slower implicit categorical learning in adult poor readers.

成年贫困读者的内隐分类学习速度较慢。

• DOI: 10.1007/s11881-004-0014-z
• 发表时间: 2004
• 期刊: Annals of dyslexia.
• 作者: Sperling,AnneJ;Lu,Zhong-Lin;Manis,FranklinR
• 通讯作者: Manis,FranklinR

Attention extracts signal in external noise: a BOLD fMRI study.

• DOI: 10.1162/jocn.2010.21511
• 发表时间: 2011-05
• 期刊: Journal of cognitive neuroscience
• 影响因子: 3.2
• 作者: Lu ZL;Li X;Tjan BS;Dosher BA;Chu W
• 通讯作者: Chu W