Core 1: Biostatistics and Bioinformatics Core

项目总结 生物统计和生物信息学核心设施为所有66号公路提供最先进的统计支持 子宫内膜癌孢子调查员和项目。核心将在所有方面提供统计支持 研究设计、研究执行和监测、数据库开发和质量控制以及数据分析 和解释。生物统计和生物信息学核心成员拥有不同的专业知识，加起来有57 多年担任生物统计师和生物信息学家，并与孢子建立了长期的合作关系 华盛顿大学医学院，俄克拉荷马大学健康科学中心成员，以及 新墨西哥大学。他们的统计专长将支持新开发的研究主题 孢子项目，如贝叶斯适应性试验设计、免疫治疗和靶向治疗试验设计， 生物标记物引导的个性化医学研究、下一代测序和高通量组学数据 分析。生物统计和生物信息学核心团队还拥有广泛的专业知识， 中心和监控少数应计费用、OnCore、RedCap和临床数据管理/分析 学习。在目标1中，核心将为孢子项目提供生物统计和生物信息学合作 发展研究计划研究。核心成员已经并将继续定期参与 孢子项目调查员会议，并为设计研究和分析数据提供统计支持。 此外，他们将帮助发展研究计划的获奖者设计研究和分析数据。在……里面 目标2，核心将为职业生涯早期的研究人员提供生物统计学和生物信息学支持和培训 通过职业提升计划。在其活动中，核心将利用#年的临床试验办公室 他们各自的癌症中心有多种用途：创建数据收集表格，统一不良事件 报告和组织样本存储和管理；以及整理/整合来自高吞吐量的输出 基因组学，以简化数据分析和解释。在实现其目标的过程中，生物统计学和 生物信息学核心将确保强大的统计方法和可重复的组学分析可用 支持所有66号路线子宫内膜癌孢子调查人员。

PROJECT SUMMARY The Biostatistics and Bioinformatics Core facility provides state-of-the-art statistical support for all Route 66 Endometrial Cancer SPORE investigators and projects. The Core will provide statistical support on all aspects of study design, study execution and monitoring, database development and quality control, and data analysis and interpretation. Biostatistics and Bioinformatics Core members have diverse expertise, a combined 57 years as faculty biostatisticians and bioinformaticians, and established long-term collaborations with SPORE members at Washington University School of Medicine, University of Oklahoma Health Sciences Center, and University of New Mexico. Their statistical expertise will support newly developing research themes of the SPORE projects, such as Bayesian adaptive trial design, immunotherapy and target therapy trial design, biomarker-guided personalized medicine study, next-generation sequencing, and high-throughput omics data analysis. The Biostatistics and Bioinformatics Core team also has extensive expertise collaborating across centers and in monitoring minority accrual, OnCore, REDCap, and data management/analysis for clinical studies. In Aim 1, the Core will provide biostatistics and bioinformatics collaborations for SPORE projects and Developmental Research Program studies. Core members have and will continue to regularly participate in SPORE project investigator meetings and provide statistical support for designing studies and analyzing data. Additionally, they will help Developmental Research Program awardees design studies and analyze data. In Aim 2, the Core will provide biostatistics and bioinformatics support and training to early-career investigators through the Career Enhancement Program. In their activities, the Core will draw on Clinical Trials Offices in their respective Cancer Centers for multiple purposes: creating forms for data collection, uniform adverse event reports, and tissue sample storage and management; and collating/integrating outputs from high-throughput genomics to streamline data analysis and interpretation. In achieving its aims, the Biostatistics and Bioinformatics Core will ensure that robust statistical methods and reproducible omics analyses are available to support all Route 66 Endometrial Cancer SPORE investigators.