Serious gaming for chemotherapy-induced nausea and vomiting in older adults with cancer: A randomized clinical trial
认真玩游戏可治疗老年癌症患者化疗引起的恶心和呕吐:一项随机临床试验
基本信息
- 批准号:10710034
- 负责人:
- 金额:$ 50万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-26 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:Accident and Emergency departmentAddressAdherenceAdoptedAdultAgeAge YearsAntiemeticsBehaviorBeliefCancer PatientClinical Trials DesignCognitiveControl GroupsDataDecision MakingDehydrationEducationEffectivenessElderlyElectronicsEmergency department visitEnrollmentEnvironmentExclusionExposure toFloridaFoodFrightGoalsGuidelinesHealthHealth behaviorHealthcareHomeHospitalizationImpairmentInterventionKidneyLearningLiquid substanceMalignant NeoplasmsNauseaNausea and VomitingNausea and Vomiting TherapyNewly DiagnosedOncologistOutcomePainParticipantPatient observationPatient-Focused OutcomesPatientsPerceptionPharmaceutical PreparationsPhysiciansPilot ProjectsPlayPopulationPreventionPrevention strategyProviderPsychological reinforcementQuality of lifeRandomizedReportingResearchResearch PersonnelResearch PriorityRestRiskRisk ReductionSample SizeSamplingSelf CareSelf ManagementSeveritiesSymptomsTechnologyTestingToxic effectTrainingTreatment-related toxicityUnited States National Institutes of HealthVisitVisualizationWorkacademic standardadverse event riskattentional controlcancer diagnosiscancer therapycare seekingchemotherapyclinical research sitecognitive changecomparison controlcomparison interventioncostdaily functioningeffectiveness evaluationefficacy evaluationexperiencefollow-upfunctional improvementgroup interventionhigh riskimprovednon-compliancenovelpreventprimary outcomerandomized, clinical trialsrecruitsecondary outcomeside effectsimulationsymptom self managementyoung adult
项目摘要
Project Summary
Older adults are at higher risk of toxicity and progressive severe effects related to cancer treatment.
They experience numerous side effects from cancer treatment including chemotherapy-induced
nausea and vomiting (CINV), but often undermanage it because they do not believe their actions to
self-manage CINV will be effective. Many older adults report taking anti-nausea medication only
when CINV is severe and some adopt a ‘watchful waiting” strategy as they wait for CINV to go away on
its own. This lack of self- management leads to reduced daily functioning, reduced adherence to
treatment, increased healthcare use (emergency department and hospital admissions) and cost, and
lower quality of life. There is a critical need for new strategies to assist older adults in engaging in
more active preventative and self-management behaviors at home to reduce negative outcomes. Our
team developed and tested a serious game intervention that directly addresses older adults’ erroneous
beliefs about CINV management. The eSSET-CINV intervention is a technology-based educational
simulation in which older adults learn to apply what they have previously learned about CINV self-
management strategies to an avatar who is at high risk for nausea at home after chemotherapy.
Players make decisions to prevent CINV and to self-manage it when it occurs. Our preliminary study
showed that older adults who were exposed to the eSSET-CINV intervention used twice as many
CINV preventative strategies than those who did not get the intervention. The goal of this study is to
determine the eSSET-CINV’s effectiveness at reducing CINV severity and healthcare use and
increasing functioning and quality of life. We will use a 2-group (intervention, attention control)
randomized clinical trial design. Aim 1 of this study is to examine changes in CINV severity, self-
management behaviors, functioning, QOL, cognitive representation and healthcare use within the
intervention group from baseline to completion of the study. Aim 2 is to determine efficacy of the
eSSET-CINV intervention by comparing differences in primary outcomes (CINV severity, healthcare
use) and secondary outcomes (self-management behaviors, functioning, and QOL) between groups at
each follow-up visit and completion of the study. A sample of 500 older adults will be recruited. The
intervention group will receive the eSSET-CINV at baseline, the attention control will receive it at the
end of the study. Both groups will be followed for 6 months. Our long-term goal is to develop unique,
culturally relevant serious games that allow older adults to practice making side-effect related self-
care decisions at home in a no-risk simulated environment. This research addresses the NIH research
priorities facilitating changes in cancer symptom prevention and self-management through increasing
positive health behaviors and improved health outcomes in an understudied population.
项目摘要
老年人与癌症治疗相关的毒性和进行性严重影响的风险更高。
他们经历了癌症治疗的许多副作用,包括化疗引起的
恶心和呕吐(CINV),但往往管理不善,因为他们不相信他们的行为,
自我管理的CINV将是有效的。许多老年人报告只服用抗恶心药物
当CINV严重时,一些人采取“警惕等待”策略,等待CINV消失。
它自己的。这种自我管理的缺乏导致日常功能降低,
治疗,增加医疗保健使用(急诊室和住院)和成本,以及
生活质量较低。迫切需要制定新的战略,帮助老年人参与
在家中采取更积极的预防和自我管理行为,以减少不良后果。我们
团队开发并测试了一种严肃的游戏干预,直接解决老年人的错误行为。
对CINV管理的信念。eSSET-CINV干预是一种基于技术的教育,
老年人学习应用他们以前学到的关于CINV自我的模拟,
管理策略的化身谁是在化疗后在家里恶心的高风险。
玩家做出决定,以防止CINV,并在发生时进行自我管理。我们的初步研究
显示,暴露于eSSET-CINV干预的老年人使用的药物是
CINV预防策略比那些谁没有得到干预。本研究的目的是
确定eSSET-CINV在降低CINV严重程度和医疗保健使用方面的有效性,
提高功能和生活质量。我们将使用2组(干预,注意力控制)
随机临床试验设计。本研究的目的1是检查CINV严重程度、自身
管理行为、功能、QOL、认知表征和医疗保健使用
干预组从基线到研究完成。目的2是确定
通过比较主要结局(CINV严重程度、医疗保健
使用)和次要结果(自我管理行为,功能和QOL)
每次随访访视和研究完成。将招募500名老年人作为样本。的
干预组将在基线时接受eSSET-CINV,注意力控制组将在
研究结束。两组均随访6个月。我们的长期目标是开发独特的,
与文化相关的严肃游戏,让老年人练习制作与副作用相关的自我,
在无风险的模拟环境中在家做出护理决定。这项研究涉及NIH的研究
优先事项促进癌症症状预防和自我管理的变化,
积极的健康行为和改善的健康结果在一个未充分研究的人群。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Victoria Loerzel其他文献
Victoria Loerzel的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Victoria Loerzel', 18)}}的其他基金
Serious gaming for chemotherapy-induced nausea and vomiting in older adults with cancer: A randomized clinical trial
认真玩游戏可治疗老年癌症患者化疗引起的恶心和呕吐:一项随机临床试验
- 批准号:
10441783 - 财政年份:2022
- 资助金额:
$ 50万 - 项目类别:
相似海外基金
Pharmacy-led Transitions of Care Intervention to Address System-Level Barriers and Improve Medication Adherence in Socioeconomically Disadvantaged Populations
药房主导的护理干预转型,以解决系统层面的障碍并提高社会经济弱势群体的药物依从性
- 批准号:
10594350 - 财政年份:2023
- 资助金额:
$ 50万 - 项目类别:
Evaluating Centralizing Interventions to Address Low Adherence to Lung Cancer Screening Follow-up in Decentralized Settings
评估集中干预措施,以解决分散环境中肺癌筛查随访依从性低的问题
- 批准号:
10738120 - 财政年份:2023
- 资助金额:
$ 50万 - 项目类别:
Suubi-Mhealth: A mobile health intervention to address depression and improve ART adherence among Youth living with HIV (YLHIV) in Uganda
Suubi-Mhealth:一种移动健康干预措施,旨在解决乌干达艾滋病毒感染者 (YLHIV) 青少年的抑郁症问题并提高抗逆转录病毒疗法的依从性
- 批准号:
10526768 - 财政年份:2022
- 资助金额:
$ 50万 - 项目类别:
Suubi-Mhealth: A mobile health intervention to address depression and improve ART adherence among Youth living with HIV (YLHIV) in Uganda
Suubi-Mhealth:一种移动健康干预措施,旨在解决乌干达艾滋病毒感染者 (YLHIV) 青少年的抑郁症问题并提高抗逆转录病毒疗法的依从性
- 批准号:
10701072 - 财政年份:2022
- 资助金额:
$ 50万 - 项目类别:
A behavioral intervention for Black men who have sex with men and live with HIV to address intersectional stigma and improve antiretroviral therapy adherence
针对男男性行为且感染艾滋病毒的黑人男性进行行为干预,以解决交叉耻辱并提高抗逆转录病毒治疗的依从性
- 批准号:
10679092 - 财政年份:2021
- 资助金额:
$ 50万 - 项目类别:
A behavioral intervention for Black men who have sex with men and live with HIV to address intersectional stigma and improve antiretroviral therapy adherence
针对男男性行为且感染艾滋病毒的黑人男性进行行为干预,以解决交叉耻辱并提高抗逆转录病毒治疗的依从性
- 批准号:
10432133 - 财政年份:2021
- 资助金额:
$ 50万 - 项目类别:
A behavioral intervention for Black men who have sex with men and live with HIV to address intersectional stigma and improve antiretroviral therapy adherence
针对男男性行为且感染艾滋病毒的黑人男性进行行为干预,以解决交叉耻辱并提高抗逆转录病毒治疗的依从性
- 批准号:
10327065 - 财政年份:2021
- 资助金额:
$ 50万 - 项目类别:
Leveraging Technology to Address Access and Adherence to Conventional Hospital-Based Pulmonary Rehabilitation in Veterans with COPD
利用技术解决慢性阻塞性肺病退伍军人接受和坚持传统医院肺康复的问题
- 批准号:
10377366 - 财政年份:2019
- 资助金额:
$ 50万 - 项目类别:
Leveraging Technology to Address Access and Adherence to Conventional Hospital-Based Pulmonary Rehabilitation in Veterans with COPD
利用技术解决慢性阻塞性肺病退伍军人接受和坚持传统医院肺康复的问题
- 批准号:
10574496 - 财政年份:2019
- 资助金额:
$ 50万 - 项目类别:
Targeted interventions to address the multi-level effects of gender-based violence on PrEP uptake and adherence among adolescent girls and young women in Kenya
有针对性的干预措施,以解决性别暴力对肯尼亚少女和年轻妇女接受和坚持 PrEP 的多层面影响
- 批准号:
9403567 - 财政年份:2017
- 资助金额:
$ 50万 - 项目类别: