Serious gaming for chemotherapy-induced nausea and vomiting in older adults with cancer: A randomized clinical trial

认真玩游戏可治疗老年癌症患者化疗引起的恶心和呕吐:一项随机临床试验

基本信息

  • 批准号:
    10710034
  • 负责人:
  • 金额:
    $ 50万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-09-26 至 2027-06-30
  • 项目状态:
    未结题

项目摘要

Project Summary Older adults are at higher risk of toxicity and progressive severe effects related to cancer treatment. They experience numerous side effects from cancer treatment including chemotherapy-induced nausea and vomiting (CINV), but often undermanage it because they do not believe their actions to self-manage CINV will be effective. Many older adults report taking anti-nausea medication only when CINV is severe and some adopt a ‘watchful waiting” strategy as they wait for CINV to go away on its own. This lack of self- management leads to reduced daily functioning, reduced adherence to treatment, increased healthcare use (emergency department and hospital admissions) and cost, and lower quality of life. There is a critical need for new strategies to assist older adults in engaging in more active preventative and self-management behaviors at home to reduce negative outcomes. Our team developed and tested a serious game intervention that directly addresses older adults’ erroneous beliefs about CINV management. The eSSET-CINV intervention is a technology-based educational simulation in which older adults learn to apply what they have previously learned about CINV self- management strategies to an avatar who is at high risk for nausea at home after chemotherapy. Players make decisions to prevent CINV and to self-manage it when it occurs. Our preliminary study showed that older adults who were exposed to the eSSET-CINV intervention used twice as many CINV preventative strategies than those who did not get the intervention. The goal of this study is to determine the eSSET-CINV’s effectiveness at reducing CINV severity and healthcare use and increasing functioning and quality of life. We will use a 2-group (intervention, attention control) randomized clinical trial design. Aim 1 of this study is to examine changes in CINV severity, self- management behaviors, functioning, QOL, cognitive representation and healthcare use within the intervention group from baseline to completion of the study. Aim 2 is to determine efficacy of the eSSET-CINV intervention by comparing differences in primary outcomes (CINV severity, healthcare use) and secondary outcomes (self-management behaviors, functioning, and QOL) between groups at each follow-up visit and completion of the study. A sample of 500 older adults will be recruited. The intervention group will receive the eSSET-CINV at baseline, the attention control will receive it at the end of the study. Both groups will be followed for 6 months. Our long-term goal is to develop unique, culturally relevant serious games that allow older adults to practice making side-effect related self- care decisions at home in a no-risk simulated environment. This research addresses the NIH research priorities facilitating changes in cancer symptom prevention and self-management through increasing positive health behaviors and improved health outcomes in an understudied population.
项目摘要 老年人与癌症治疗相关的毒性和进行性严重影响的风险更高。 他们经历了癌症治疗的许多副作用,包括化疗引起的 恶心和呕吐(CINV),但往往管理不善,因为他们不相信他们的行为, 自我管理的CINV将是有效的。许多老年人报告只服用抗恶心药物 当CINV严重时,一些人采取“警惕等待”策略,等待CINV消失。 它自己的。这种自我管理的缺乏导致日常功能降低, 治疗,增加医疗保健使用(急诊室和住院)和成本,以及 生活质量较低。迫切需要制定新的战略,帮助老年人参与 在家中采取更积极的预防和自我管理行为,以减少不良后果。我们 团队开发并测试了一种严肃的游戏干预,直接解决老年人的错误行为。 对CINV管理的信念。eSSET-CINV干预是一种基于技术的教育, 老年人学习应用他们以前学到的关于CINV自我的模拟, 管理策略的化身谁是在化疗后在家里恶心的高风险。 玩家做出决定,以防止CINV,并在发生时进行自我管理。我们的初步研究 显示,暴露于eSSET-CINV干预的老年人使用的药物是 CINV预防策略比那些谁没有得到干预。本研究的目的是 确定eSSET-CINV在降低CINV严重程度和医疗保健使用方面的有效性, 提高功能和生活质量。我们将使用2组(干预,注意力控制) 随机临床试验设计。本研究的目的1是检查CINV严重程度、自身 管理行为、功能、QOL、认知表征和医疗保健使用 干预组从基线到研究完成。目的2是确定 通过比较主要结局(CINV严重程度、医疗保健 使用)和次要结果(自我管理行为,功能和QOL) 每次随访访视和研究完成。将招募500名老年人作为样本。的 干预组将在基线时接受eSSET-CINV,注意力控制组将在 研究结束。两组均随访6个月。我们的长期目标是开发独特的, 与文化相关的严肃游戏,让老年人练习制作与副作用相关的自我, 在无风险的模拟环境中在家做出护理决定。这项研究涉及NIH的研究 优先事项促进癌症症状预防和自我管理的变化, 积极的健康行为和改善的健康结果在一个未充分研究的人群。

项目成果

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Victoria Loerzel其他文献

Victoria Loerzel的其他文献

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{{ truncateString('Victoria Loerzel', 18)}}的其他基金

Serious gaming for chemotherapy-induced nausea and vomiting in older adults with cancer: A randomized clinical trial
认真玩游戏可治疗老年癌症患者化疗引起的恶心和呕吐:一项随机临床试验
  • 批准号:
    10441783
  • 财政年份:
    2022
  • 资助金额:
    $ 50万
  • 项目类别:

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