Hawaii IDeA Center for Pediatric and Adolescent Clinical Trials 2 (HIPACT 2)

摘要 夏威夷IDEA儿童和青少年临床试验中心第二周期的主要目标2 (HIPACT2)将利用HIPACT头四年的成功，作为一个富有成效和参与度的 儿童健康结果理念对环境的影响--美国儿科临床试验网络(ECHO ISPCTN)站点。HIPACT的头四年启动了ECHO ISPCTN临床试验，聘请了新的初级 ECHO ISPCTN的研究人员在HIPACT的合作伙伴那里建立了儿科临床试验能力 机构。作为一个相对较小的回声的ISPCTN部位，儿科参与临床的历史很少 试验，HIPACT成功地激励和吸引了专业领域的新初级教员 发展活动。HIPACT的初步成功激励了学术界和社区的势头 努力充分参与HIPACT2的规划，包括新承诺的合作伙伴。我们已经确立了 通过以下途径参与HIPACT2的机制：儿科和母胎医学 夏威夷儿童研究(HIPR)学者计划。此外，我们将努力提供给 ECHO ISPCTN活动的目标是增加参与HIPACT2的初级教员人数。与 总体目标是改善农村和农村地区各种多族裔人口的健康和福祉 夏威夷服务不足的地区，包括夏威夷土著社区和太平洋移民人口 岛民和亚洲人，HIPACT2将利用HIPACT与夏威夷太平洋健康中心建立的合作伙伴关系 (HPH)卡皮奥拉尼妇女儿童医学中心(KMCWC)和怀亚奈海岸综合健康中心 中心(WCCHC)。提出了以下具体目标：目标1：积极促进和参与 ECHO ISPCTN儿科临床试验；目标2：提供临床试验，造福农村和服务不足的人 婴儿、儿童和青少年，其中许多是夏威夷土著、太平洋岛民和亚洲人；目标3：至 参与ECHO ISPCTN多中心临床试验研究的科学；目标4：指导一名干部 初级教员通过夏威夷儿科研究(HIPR)学者计划。综上所述，HIPACT2将充当 Echo ISPCTN的热切合作伙伴，在第二个五年融资周期中具有良好的历史记录 参与和成就、机构支持和新承诺的合作伙伴。它将丰富机会 用于教师研究培训和教育，参与合作的多中心临床试验研究，以及 让农村和服务不足的社区参与，以改善夏威夷和全国的健康状况。

ABSTRACT The principal objective of this second cycle of Hawaii IDeA Center for Pediatric and Adolescent Clinical Trials2 (HIPACT2) is to capitalize on the success of the first fouryears of HIPACT as a productive and engaged Environmental Influences of Child Health Outcomes IDeA States Pediatric Clinical Trials Network (ECHO ISPCTN) site. The first four years of HIPACT launched ECHO ISPCTN clinical trials, engaged new junior investigators in ECHO ISPCTN endeavors and built pediatric clinical trials capacity at HIPACT's partner institutions. As a relatively small ECHO ISPCTN site with a historical paucity of pediatric involvement in clinical trials, HIPACT successfully inspired and engaged new junior faculty across the spectrum of professional development activities. The initial success of HIPACT spirited the momentum for academic and community efforts to participate fully in the planning of HIPACT2 including newly committed partners. We have established a mechanism to participate in HIPACT2 by engaging pediatric and maternal-fetal medicine faculty through the Hawaii Pediatric Research (HIPR) Scholars Program. Moreover, we will endeavor to feed into the pipeline of ECHO ISPCTN activities with the goal of increasing the number of junior faculty involved in HIPACT2. With the overarching goal to improve the health and wellbeing of the diverse multiethnicpopulations in rural and underserved areas of Hawaii including indigenous Hawaiian communities, and immigrant populations of Pacific Islanders and Asians, HIPACT2will capitalize on established HIPACT partnerships with Hawaii Pacific Health (HPH) Kapiolani Medical Center for Women and Children (KMCWC), and Waianae Coast Comprehensive Health Center (WCCHC). The following Specific Aims are proposed: Aim 1: To actively contribute to and participate in ECHO ISPCTN pediatric clinical trials; Aim 2: To provide access to clinical trials to benefit rural and underserved infants, children, and adolescents, many of who are Native Hawaiians, Pacific Islanders, and Asians; Aim 3: To participate in the “science” of ECHO ISPCTN multicenter clinical trials research; Aim 4: To mentor a cadre of junior faculty via the Hawaii Pediatric Research (HIPR) Scholars Program. Taken together, HIPACT2 will act as an eager partner in ECHO ISPCTN in this second five-year cycle of funding with a strong historical track record of engagement and achievement, institutional support, and newly committed partners. It will enrich opportunities for faculty research training and education, participation in collaborative multicenter clinical trial research, and engage rural and underserved communities to improve health outcomes in Hawaii and across the nation.