Hawaii IDeA Center for Pediatric and Adolescent Clinical Trials 2 (HIPACT 2)

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ABSTRACT The principal objective of this second cycle of Hawaii IDeA Center for Pediatric and Adolescent Clinical Trials2 (HIPACT2) is to capitalize on the success of the first fouryears of HIPACT as a productive and engaged Environmental Influences of Child Health Outcomes IDeA States Pediatric Clinical Trials Network (ECHO ISPCTN) site. The first four years of HIPACT launched ECHO ISPCTN clinical trials, engaged new junior investigators in ECHO ISPCTN endeavors and built pediatric clinical trials capacity at HIPACT's partner institutions. As a relatively small ECHO ISPCTN site with a historical paucity of pediatric involvement in clinical trials, HIPACT successfully inspired and engaged new junior faculty across the spectrum of professional development activities. The initial success of HIPACT spirited the momentum for academic and community efforts to participate fully in the planning of HIPACT2 including newly committed partners. We have established a mechanism to participate in HIPACT2 by engaging pediatric and maternal-fetal medicine faculty through the Hawaii Pediatric Research (HIPR) Scholars Program. Moreover, we will endeavor to feed into the pipeline of ECHO ISPCTN activities with the goal of increasing the number of junior faculty involved in HIPACT2. With the overarching goal to improve the health and wellbeing of the diverse multiethnicpopulations in rural and underserved areas of Hawaii including indigenous Hawaiian communities, and immigrant populations of Pacific Islanders and Asians, HIPACT2will capitalize on established HIPACT partnerships with Hawaii Pacific Health (HPH) Kapiolani Medical Center for Women and Children (KMCWC), and Waianae Coast Comprehensive Health Center (WCCHC). The following Specific Aims are proposed: Aim 1: To actively contribute to and participate in ECHO ISPCTN pediatric clinical trials; Aim 2: To provide access to clinical trials to benefit rural and underserved infants, children, and adolescents, many of who are Native Hawaiians, Pacific Islanders, and Asians; Aim 3: To participate in the “science” of ECHO ISPCTN multicenter clinical trials research; Aim 4: To mentor a cadre of junior faculty via the Hawaii Pediatric Research (HIPR) Scholars Program. Taken together, HIPACT2 will act as an eager partner in ECHO ISPCTN in this second five-year cycle of funding with a strong historical track record of engagement and achievement, institutional support, and newly committed partners. It will enrich opportunities for faculty research training and education, participation in collaborative multicenter clinical trial research, and engage rural and underserved communities to improve health outcomes in Hawaii and across the nation.